Distinct ensemble codes in hippocampal areas CA3 and CA1

The hippocampus has differentiated into an extensively connected recurrent stage (CA3) followed by a feed-forward stage (CA1). We examined the function of this structural differentiation by determining how cell ensembles in rat CA3 and CA1 generate representations of rooms with common spatial elements. In CA3, distinct subsets of pyramidal cells were activated in each room, regardless of the similarity of the testing enclosure. In CA1, the activated populations overlapped, and the overlap increased in similar enclosures. After exposure to a novel room, ensemble activity developed slower in CA3 than CA1, suggesting that the representations emerged independently.     

Global contested terrain: The case of the tuna-dolphin controversy

Employing the case of the global tuna-fish industry, it is argued that the process of globalization is contested terrain as it opens free spaces to some classes or groups and closes free spaces to others; that the nation-States' regulatory abilities are weakened; and finally, that while some social movements may gain, others are marginalized. Three basic conclusions are reached. (1) The industry's actions were successfully contested by environmental groups supported by the legislative and judicial branches of the US State. (2) Simultaneously, pro-environmental legislation is currently threatened, along with several national and international environmental accords. (3) Workers in the US and, particularly, in Latin America are paying the consequences of the introduction of pro-environmental legislation and the actions of transnational corporations (TNCs).Douglas H. Constance is Research Associate of Rural Sociology at the University of Missouri-Columbia. His research interests include the sociology of agriculture and environmental sociology. He is the author of several journal articles and is coauthor with Alessandro Bonanno of the forthcoming bookCaught in the Net: The Global Tuna Industry, Environmentalists, and the State.     

Human CHN1 mutations hyperactivate alpha2-chimaerin and cause Duane's retraction syndrome

Duane's retraction syndrome (DRS) is a complex congenital eye movement disorder caused by aberrant innervation of the extraocular muscles by axons of brainstem motor neurons. Studying families with a variant form of the disorder (DURS2-DRS), we have identified causative heterozygous missense mutations in CHN1, a gene on chromosome 2q31 that encodes alpha2-chimaerin, a Rac guanosine triphosphatase-activating protein (RacGAP) signaling protein previously implicated in the pathfinding of corticospinal axons in mice. We found that these are gain-of-function mutations that increase alpha2-chimaerin RacGAP activity in vitro. Several of the mutations appeared to enhance alpha2-chimaerin translocation to the cell membrane or enhance its ability to self-associate. Expression of mutant alpha2-chimaerin constructs in chick embryos resulted in failure of oculomotor axons to innervate their target extraocular muscles. We conclude that alpha2-chimaerin has a critical developmental function in ocular motor axon pathfinding.     

Assessing the potential of marine Natura 2000 sites to produce ecosystem‐wide effects in rocky reefs: A case study from Sardinia Island (Italy)

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Assessing the impacts of tourism on the world's largest fish Rhincodon typus at Panaon Island,Southern Leyte,Philippines

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Size selection by diamond- and square-mesh codends in multi-species Mediterranean demersal trawl fisheries

Mediterranean demersal trawl fisheries traditionally operate using small diamond-shape meshes in the codend, which tend to retain almost all animals. We investigated the effect of mesh configuration on the size selectivity of nine species (the scaldfish Arnoglossus laterna, the broad-tail shortfin squid Illex coindettii, the European hake Merluccius merluccius, the red mullet Mullus barbatus, the Norway lobster Nephrops norvegicus, the common pandora Pagellus erythrinus, the deepwater rose shrimp Parapenaeus longirostris, the Mediterranean horse mackerel Trachurus mediterraneus and the poor-cod Trisopterus minutus capelanus) commonly captured in the Mediterranean demersal trawls. Two codends having meshes with the same opening (ca. 38 mm) but different mesh configuration (DM38: diamond-mesh and SM38: square-mesh configuration) were fished daily and alternately on the same trawl. They demonstrated a substantial improvement in selectivity with square-mesh. Selectivity was measured using the covered codend technique, the cover being supported by circular hoops.The results were analysed taking into account the between-haul variation in selectivity. Two other important external variables were identified: the trawling depth and the codend catch, which for some species influenced between-haul variation, but there was no evidence of a coherent effect on selectivity parameters.The selectivity of 40 mm diamond-mesh codend has been reported to be rather poor because a large proportion of the codend catch is immature and smaller than the minimum landing size (MLS) or first maturity size. With the exception of the flatfish (A. laterna), the effect of a change of mesh configuration from diamond- to square-mesh on size selectivity positively affected the retention length at 50% (L₅₀). However, square-meshes were found to be unsuitable for flat and/or deep-bodied fish as these escape more readily from diamond-meshes.The Council Regulation (EC) No. 1967/2006, concerning management measures for the sustainable exploitation of fishery resources in the Mediterranean, establishes the MLS of marine organisms. However, the increase in L₅₀ with square-mesh would not avoid some of the existing contradictions in allowing the use of codend mesh which leads to lower L₅₀ than the MLS.     

The effects of dietary fibre addition on the quality of common cereal products

Cereal products are consumed daily by the majority of the population. Popular belief is that these cereal products, rich in carbohydrates, produce a high glycaemic response and may not be a contributing factor to the obesity epidemic throughout the world. Recently the food industry has investigated ways of improving the overall nutritional balance of carbohydrate rich foods and focused on increasing their dietary fibre (DF) contents at the expense of readily digestible carbohydrates. It is well documented that dietary fibre is involved in disease prevention and enhanced health of consumers. Moreover, the food industry can take advantage of the physicochemical properties of fibre to improve the viscosity, texture, sensory characteristics and shelf-life of their products. The focus of this review paper is on the influence of DFs (inulin, fructo-oligofructose, β-glucans, arabinoxylans and resistant starch) supplementation on the quality and nutritional aspects of common foods containing cereals- pasta, bread, muffins/cakes and extruded snacks. This review reports on the evidence regarding fibre enrichment of cereal foods and looks at the advances and future trends in enriched dietary fibre cereal products.     

Parameters causing variation between soil screening values and the effect of harmonization

Background, aim, and scope

This paper discusses the variation between generic soil screening values (SSV) from 17 countries for 11 volatile organic contaminants (VOC). The variation between SSV was one to four orders-of-magnitude (OOM) depending on the SSV and landuse type. What would be the variation if parameter values are harmonized between member states?

Main Features

The effect of harmonization was visualized by firstly reviewing the technical derivation procedure for SSV for 7 SSV from five countries and collecting all parameter values that are involved in the deviation. The parameters were subdivided in scientific (e.g. algorithm plus its parameter values), political (e.g. toxicological reference) or geographical (e.g. building and soil properties) elements. Secondly, new SSV were calculated with progressively harmonized sets of scientific and/or political parameter values, while the geographical parameters varied. Thirdly, the variation between SSV was compared before and after harmonization.

Results

Results show that harmonizing algorithms plus other scientific and political parameters are suited for harmonization. The variation decreases to 1 OOM, after scientific and political parameters were harmonized. Geographical parameters seem to have less impact on the differences between SSV.

Discussion

So, should we harmonize the procedures for deriving SSV between EU member states? The need for discussing harmonization is also raised by the upcoming EU Soil Framework Directive.

Conclusions

Clearly common generic SSV across all of Europe are not appropriate, since countries are allowed to include member state specific geographical and cultural elements and also political decision making. By harmonizing scientific and/or political parameters differences between SSV can be made more transparent between member states and it will encourage convergence in procedures among member states to ensure neutral conditions of competition and a coherent soil protection regime throughout Europe.

Recommendations and perspectives

To promote uniformity it is recommended to construct a toolbox for the calculation of human health risk exposure, carried by a European consensus, that includes different model algorithms for which fixed and flexible input parameters are made available. Fixed algorithm parameters are standardized and applied uniformly by all member states, e.g. physico-chemical parameters, while flexible input parameters permits member states to include region or country specific parameter values and policy decisions.     

Molecular characteristics of humic acids extracted from compost at increasing maturity stages

The molecular composition of humic acids (HA) extracted from compost at increasing maturity stages was determined by off-line TMAH-thermochemolysis-GC-MS, in combination with solid-state nuclear magnetic resonance (NMR) and infrared (IR) spectroscopies. While spectroscopy measurements followed the bulk changes, thermochemolysis provided a detailed molecular variation of HA composition. Both thermochemolysis and spectroscopy indicated that polysaccharides, alkyl, cyclic, and aromatic compounds were the predominant components of HA, the stable fraction of compost. NMR dipolar dephasing (DD) experiments confirmed that HA extracts contained lignin in lower amount than its oxidized degradation products. The progressive compost maturity was reflected in HA extracts by a decrease of carbohydrate content and a selective preservation of hydrophobic alkyl molecules, such as medium- and long-chain fatty acids, aliphatic alcohols, linear hydrocarbons, and plant polyester derivatives, like long-chain alkyl dicarboxylic acids, and ω-hydroxyacids. Spectroscopy results showed a concomitant entrapment in HA of biolabile compounds, such as peptidic moieties. The wide range of identified lipid components and plant biomarkers may represent useful tools to trace origin, quality, and transformation of amended compost in soil ecosystems.