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31.
Ivermectin is one of the most commonly used drugs in pharmacotherapy of parasitic diseases in domestic and wild animals caused
by parasitic nematodes and arthropods. However, ivermectin and other avermectins very often produce side-effects in hosts.
The most dominant clinical symptom of ivermectin toxicity in domestic and wild animals is CNS depression. In nematodes, the
target site of ivermectin’s action is glutamate-gated chloride-channel receptor and GABA receptor. The depressive effect of
ivermectin in mammals might include more than one mechanism; therefore, the anticonvulsive effect of ivermectin against convulsions
caused by lidocaine and strychnine was evaluated. Ivermectin antagonized lidocaine- and strychnine-induced convulsions in
rats, although these have different mechanisms. In the present study, the anticonvulsive ED50 of ivermectin for lidocaine-induced convulsions was 2.44 mg/kg (95% CL 1.67 to 3.57 mg/kg), whereas for convulsions induced
by strychnine it was higher at 4.25 mg/kg (95% CL 2.32 to 3.78 mg/kg). At the same time, both anticonvulsive doses are significantly
lower then the observed LD50 of ivermectin (18.20 mg/kg). Furthermore, flumazenil (0.1 and 0.2 mg/kg), an antagonist of benzodiazepine receptors, antagonizes
just one part of these anticonvulsive effects of ivermectin. Our results show the significant anticonvulsive properties of
ivermectin and support the findings that ivermectin in the CNS of mammals produces multiple inhibitory effects, probably through
participation in the function of GABA-sensitive and GABA-insensitive chloride channels. 相似文献
32.
Summary The occurrence of chromosomal interchanges was studied in F1 hyrids in two diallel schemes, including nine accessions of Triticum aestivum subsp. spelta, originating from Iran, Europe and North Africa, and the common wheat variety Chinese Spring as a reference. Seven accessions of subsp. spelta differed in one translocation from Chinese Spring. The European accession Grey differed in one or perhaps two interchanges from the reference variety, and Iran 417a showed a difference of three interchanges with Chinese Spring. In total six or perhaps seven interchanges were observed. Thus the number of translocation events in subsp. spelta appeared to be low. One translocation was unique and occurred only in the accession from North Africa. Also one accession from Europe, the landrace Schwarzwald, possibly carried a unique translocation. In both diallels an interchange with a relatively low coefficient of multivalent realisation at first meiotic metaphase was observed in most accessions. The two extra translocations in Iran 417a are considered to be the result of more recent translocation events, whereas the possible second translocation in accession Grey showed such a low coefficient of multivalent realisation that its existence could be doubted. 相似文献
33.
Branimir Urlić Gvozden Dumičić Smiljana Goreta Ban Marija Romić 《Journal of plant nutrition》2016,39(3):389-398
Understanding the mechanisms of phosphorus (P)-use efficiency (PUE) may contribute to enhancing crop P nutrition because species growth variability at low-P is well known. The experiment was carried out to evaluate the response of kale genotypes to different P supply in randomized block design in three replications. Low-P supply led to a decrease in most parameters, whereas an increase was recorded in root growth parameters. Genotypes differed in shoot dry weight (DW), leaf area, root length and area, and shoot and root P content and concentration. Root traits significantly positively correlated with PUE. Genotypes Red Russian (RR) and IJK 17 were superior in terms of shoot DW production at low P supply, and had the highest uptake efficiency. Genotypes IJK 17 and 81 had the highest P utilization efficiency, while Vates blue curled (VBC) showed the lowest PUE. Genotypes had similar shoot P content and concentration at low P supply, but large PUE differences, implying the importance of P utilization efficiency. 相似文献
34.
The influence of mesoscale weather patterns on the chemical composition of daily precipitation samples is analysed. The data of pH, sulphur from sulphates and total nitrogen are analysed for two rural sites: Plitvice station in forested part of Central Croatia (1981 to 1990) and Puntijarka suburban station on the mountain near Zagreb, the capital of Croatia (1982–1991). The two prevailing weather types in precipitation days are selected and the comparison of chemical composition of precipitation is made for each of them. The frequency distributions of pH, sulphur and nitrogen show that concentration of major ions in precipitation apparently depends on the regional scale weather type. It is shown that the seasonal variation of deposition is related to the seasonal variation in precipitation amount. In both weather types Plitvice receives more pollution than Puntijarka that is closer to urban and industrial pollution sources. Both locations are under the prevailing influence of regional pollution sources. 相似文献
35.
36.
Salières P Carré B Le Déroff L Grasbon F Paulus GG Walther H Kopold R Becker W Milosević DB Sanpera A Lewenstein M 《Science (New York, N.Y.)》2001,292(5518):902-905
Atoms interacting with intense laser fields can emit electrons and photons of very high energies. An intuitive and quantitative explanation of these highly nonlinear processes can be found in terms of a generalization of classical Newtonian particle trajectories, the so-called quantum orbits. Very few quantum orbits are necessary to reproduce the experimental results. These orbits are clearly identified, thus opening the way for an efficient control as well as previously unknown applications of these processes. 相似文献
37.
Terracciano A Abdel-Khalek AM Adám N Adamovová L Ahn CK Ahn HN Alansari BM Alcalay L Allik J Angleitner A Avia MD Ayearst LE Barbaranelli C Beer A Borg-Cunen MA Bratko D Brunner-Sciarra M Budzinski L Camart N Dahourou D De Fruyt F de Lima MP del Pilar GE Diener E Falzon R Fernando K Ficková E Fischer R Flores-Mendoza C Ghayur MA Gülgöz S Hagberg B Halberstadt J Halim MS Hrebícková M Humrichouse J Jensen HH Jocic DD Jónsson FH Khoury B Klinkosz W Knezević G Lauri MA Leibovich N Martin TA 《Science (New York, N.Y.)》2005,310(5745):96-100
Most people hold beliefs about personality characteristics typical of members of their own and others' cultures. These perceptions of national character may be generalizations from personal experience, stereotypes with a "kernel of truth," or inaccurate stereotypes. We obtained national character ratings of 3989 people from 49 cultures and compared them with the average personality scores of culture members assessed by observer ratings and self-reports. National character ratings were reliable but did not converge with assessed traits. Perceptions of national character thus appear to be unfounded stereotypes that may serve the function of maintaining a national identity. 相似文献
38.
39.
Zhou M Morgner N Barrera NP Politis A Isaacson SC Matak-Vinković D Murata T Bernal RA Stock D Robinson CV 《Science (New York, N.Y.)》2011,334(6054):380-385
The ability of electrospray to propel large viruses into a mass spectrometer is established and is rationalized by analogy to the atmospheric transmission of the common cold. Much less clear is the fate of membrane-embedded molecular machines in the gas phase. Here we show that rotary adenosine triphosphatases (ATPases)/synthases from Thermus thermophilus and Enterococcus hirae can be maintained intact with membrane and soluble subunit interactions preserved in vacuum. Mass spectra reveal subunit stoichiometries and the identity of tightly bound lipids within the membrane rotors. Moreover, subcomplexes formed in solution and gas phases reveal the regulatory effects of nucleotide binding on both ATP hydrolysis and proton translocation. Consequently, we can link specific lipid and nucleotide binding with distinct regulatory roles. 相似文献
40.
Pavel Šamonil Martin Valtera Stanislav Bek Barbora Šebková Tomáš Vrška Jakub Houška 《European Journal of Forest Research》2011,130(6):1075-1091
Soil variability was assessed in a 74.2-ha area within the Žofínsky prales natural forest. Parameters evaluated for 1765 soil
profiles inside 353 graticule plots were as follows: (1) thickness of organic horizons, (2) thickness and form of mineral
horizons, (3) humus form (HF), (4) soil taxonomic unit (STU) and (5) anomalies. In addition, soil reaction (pHKCl) and oxidizable carbon content (Cox) were measured in the laboratory for 734 samples from the upper mineral (A) and lower mineral (B) horizons. The most frequently
occurring humus form was mor followed by moder, hydromor and peaty T-horizon. Entic Podzols, Dystric Cambisols, Haplic Cambisols,
Albic Podzols, Histic (or Haplic) Gleysols, Endogleyic Stagnosols, Fibric or Hemic or Sapric Histosols and Stagnic Gleysols
were all present at the site despite its homogeneous geological bedrock. Overall coefficient of variance (CV) was lower in
terrestrial soils compared with (semi-)hydromorphic soils. Overall variance decreased in both soil groups with increasing
depth, as did CV differences between the fine (up to 10 m) and the locality scales. The lowest CV values occurred for Cox and pHKCl. The CV values differed between STUs as well. Compared to lower horizons, variograms of upper horizons showed greater autocorrelation
at the intermediate spatial scale (10–320 m)—ranging from 50 to 150 m. Semivariance values, however, reached 70–80% of sill
already at a distance of 10 m. The most significant factor of variability at all studied spatial scales is presumably the
soil disturbance regime, followed by terrain micro-topography and the effect of tree species. 相似文献