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101.
Background
The Kola Peninsula (the most northern region of the European fringe of Russia) is covered with podzolic soil and is considered the most sensitive area to acidification in Europe because of the low input rate of base cations by weathering. About 300 thousand tons of SO2 are annually emitted from stationary sources in this region. Acidic precipitation accumulates in the snow during winter, and acidic water suddenly flushes into the soil during spring snowmelt (so-called acid shock). It is therefore important to assess how the acid-sensitive podzol responds to an intensive increase in acid load. The main purpose of this paper is to show the observed data rather than to provide an analytical interpretation of the observed phenomenon. 相似文献102.
Non-timber forest products (NTFPs) represent important resources for millions of communities worldwide. Concerns over NTFP overexploitation has led to a growing number of studies on the ecological impacts of harvest. Few studies however, have addressed species harvested for multiple parts or investigated how spatial variation affects harvest patterns and their impacts. We documented rates and patterns of pruning and debarking and their impacts on density and population structure, for 12 populations of the multiuse tree, Khaya senegalensis (Meliaceae) in two ecological regions (Sudano-Guinean versus Sudanian) of Benin, West Africa. Half of the populations had low or no harvest and half were highly harvested. Patterns of pruning and debarking were size-specific, with harvesters tending to prefer larger trees. Foliage harvest pressures were very high across both regions, with >70% of trees harvested for 100% of their crowns. A significantly greater proportion of trees were harvested for foliage in the wetter Sudano-Guinean region than in Sudanian region. The reverse was true for the proportion of foliage and bark-harvested per tree. In the Sudano-Guinean region, high harvest populations had significantly lower densities of seedlings and saplings than low harvest populations. The size-class distribution coefficient of skewness was significantly correlated with rainfall, habitat, and soil type. Variation in harvesting patterns and their ecological impacts can be explained in large part by differences in water availability between the two regions. Effective conservation plans for K. senegalensis require close consideration of the environmental and land-use context in which populations occur. 相似文献
103.
Brett M. Havis Kelsey E. Walker Pamela R. F. Adkins Zhenyu Shen John R. Middleton Tamara Gull Dusty Nagy Dae Young Kim 《Journal of veterinary diagnostic investigation》2021,33(3):587
A 3-mo-old male llama was examined because of a 4-wk history of lethargy and ill thrift. Clinical examination revealed subcutaneous masses in the left prescapular and right inguinal regions, mild ataxia, a slight head tilt to the right, and right ear droop. The cria died before clinical workup was complete. At autopsy, there was generalized lymphadenomegaly, a hepatic nodule, a midbrain mass causing rostral compression of the cerebellum, and internal hydrocephalus. Microscopic findings included pyogranulomatous lymphadenitis, meningoencephalitis, hepatitis, and bronchopneumonia. Intralesional fungal spherules, most consistent with Coccidioides spp., were identified in the lymph nodes, lung, and brain. Fungal culture, single-nucleotide variation genotyping real-time PCR, and DNA sequencing confirmed Coccidioides posadasii. The dam of the cria was native to Arizona and had been moved to Missouri ~2.5 y previously. Agar gel immunodiffusion assay of the herd revealed that only the dam was positive for Coccidioides spp.; 6 herdmates were negative. Computed tomography of the dam revealed multiple nodules within the lungs and liver, which were presumed to be an active coccidioidomycosis infection. This case of systemic coccidioidomycosis in a llama native to Missouri was presumably acquired by vertical transmission from the dam. 相似文献
104.
G. N. Mauldin T. P. Foster C. W. Waddell M. E. Egan 《Veterinary and comparative oncology》2003,1(1):36-47
The process of new blood vessel formation within and around neoplastic tissue, termed angiogenesis, is a significant factor in the development, progression and metastasis of malignant tumours in all species. A major cause of death in cancer patients is the development of treatment‐resistant metastatic disease, which may be avoided by therapies that target the genetically stable population of vascular endothelial cells within tumours. Tumstatin is a small protein formed by the cleavage of the alpha‐3 subunit of the non‐collagenous domain of mammalian type IV collagen. Recombinant human Tumstatin has been shown to have potent angiostatic properties in vitro and in vivo. Tumstatin is a potent initiator of apoptosis and inhibits the proliferation and migration of vascular endothelial cells in cell culture. Recently, a fragment of Tumstatin, termed Tum5, has been shown to have biologic activity similar to the parent compound. The systemic administration of angiostatic proteins like Tum5 may result in the remission of established tumours, while preventing or delaying the onset of clinically detectable metastasis. Recombinant canine Tum5 (cTum5) was cloned and its protein expression induced in a prokaryotic vector. The resulting cTum5 protein caused dose‐dependent inhibition of vascular endothelial cells in vitro, which appears to be mediated through apoptosis. 相似文献
105.
106.
107.
Dipineto L Gargiulo A Russo TP De Luca Bossa LM Borrelli L Menna LF Fioretti A 《Avian diseases》2011,55(1):103-105
As no data are available on the prevalence of cytolethal distending toxin (cdt) genes carried by Campylobacter spp. in laying hens, this study was conducted with the aim to evaluate the prevalence of both Campylobacter spp. and cdt genes in 1680 laying hens from four different farms. The samples were analyzed by culture methods and by polymerase chain reaction. Campylobacter spp. were isolated from 1097/1680 cloacal swabs. Among the isolates, 913 were identified as Campylobacter jejuni whereas 345 were identified as Campylobacter coli. All isolates carried cdt genes. The results presented here confirm the very common occurrence of C. jejuni and C. coli in laying hens and underline that the cdt genes may also be frequently present in both C. jejuni and C. coli isolates from laying hens. 相似文献
108.
109.
Transformation by oncogenes encoding protein kinases induces the metastatic phenotype 总被引:16,自引:0,他引:16
S E Egan J A Wright L Jarolim K Yanagihara R H Bassin A H Greenberg 《Science (New York, N.Y.)》1987,238(4824):202-205
Oncogenes encoding serine/threonine or tyrosine kinases were introduced into the established rodent fibroblast cell line NIH 3T3 and tested for tumorigenic and metastatic behavior in T cell-deficient nude mice. Transforming oncogenes of the ras family were capable of converting fibroblast cell lines to fully metastatic tumors. Cell lines transformed by the kinase oncogenes mos, raf, src, fes, and fms formed experimental metastases and (in some cases) these genes were more efficient at metastatic conversion than a mutant ras gene. In contrast, cells transformed by either of two nuclear oncogenes, myc or p53, were tumorigenic when injected subcutaneously but were virtually nonmetastatic after intravenous injection. These data demonstrate that, in addition to ras, a structurally divergent group of kinase oncogenes can induce the metastatic phenotype. 相似文献
110.
van der Neut Kolfschoten M Schuurman J Losen M Bleeker WK Martínez-Martínez P Vermeulen E den Bleker TH Wiegman L Vink T Aarden LA De Baets MH van de Winkel JG Aalberse RC Parren PW 《Science (New York, N.Y.)》2007,317(5844):1554-1557
Antibodies play a central role in immunity by forming an interface with the innate immune system and, typically, mediate proinflammatory activity. We describe a novel posttranslational modification that leads to anti-inflammatory activity of antibodies of immunoglobulin G, isotype 4 (IgG4). IgG4 antibodies are dynamic molecules that exchange Fab arms by swapping a heavy chain and attached light chain (half-molecule) with a heavy-light chain pair from another molecule, which results in bispecific antibodies. Mutagenesis studies revealed that the third constant domain is critical for this activity. The impact of IgG4 Fab arm exchange was confirmed in vivo in a rhesus monkey model with experimental autoimmune myasthenia gravis. IgG4 Fab arm exchange is suggested to be an important biological mechanism that provides the basis for the anti-inflammatory activity attributed to IgG4 antibodies. 相似文献