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Abstract This Forum contribution forms a response to the thoughtful article on the role of Bt cotton for African smallholders by Rory Hillocks in International Journal of Pest Management 51(2):131–141. We urge a more nuanced approach to consideration of pesticide-related and other technical issues in the conventional cotton sector, including recent estimates of external costs to health from current patterns of pesticide use, even at the low application levels in volume/area terms reported from Africa. We examine economic and institutional aspects of cotton production and the debates centred upon the potential of Bt cotton for resource-poor farmers in developing countries. Based on research and project experience over the last decade, we discuss the role of organic cotton and the benefits it provides for African men and women smallholders, and conclude with a summary of the potential for expansion and policy, research and development needs. 相似文献
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A cellular microRNA mediates antiviral defense in human cells 总被引:4,自引:0,他引:4
Lecellier CH Dunoyer P Arar K Lehmann-Che J Eyquem S Himber C Saïb A Voinnet O 《Science (New York, N.Y.)》2005,308(5721):557-560
In eukaryotes, 21- to 24-nucleotide-long RNAs engage in sequence-specific interactions that inhibit gene expression by RNA silencing. This process has regulatory roles involving microRNAs and, in plants and insects, it also forms the basis of a defense mechanism directed by small interfering RNAs that derive from replicative or integrated viral genomes. We show that a cellular microRNA effectively restricts the accumulation of the retrovirus primate foamy virus type 1 (PFV-1) in human cells. PFV-1 also encodes a protein, Tas, that suppresses microRNA-directed functions in mammalian cells and displays cross-kingdom antisilencing activities. Therefore, through fortuitous recognition of foreign nucleic acids, cellular microRNAs have direct antiviral effects in addition to their regulatory functions. 相似文献
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Benvenuti F Hugues S Walmsley M Ruf S Fetler L Popoff M Tybulewicz VL Amigorena S 《Science (New York, N.Y.)》2004,305(5687):1150-1153
Upon maturation, dendritic cells (DCs) acquire the unique ability to activate na?ve T cells. We used time-lapse video microscopy and two-photon imaging of intact lymph nodes to show that after establishing initial contact between their dendrites and na?ve T lymphocytes, mature DCs migrate toward the contacted lymphocytes. Subsequently, the DCs tightly entrap the T cells within a complex net of membrane extensions. The Rho family guanosine triphosphatases Rac1 and Rac2 but not Rho itself control the formation of dendrites in mature DCs, their polarized short-range migration toward T cells, and T cell priming. 相似文献
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Buesseler KO Lamborg CH Boyd PW Lam PJ Trull TW Bidigare RR Bishop JK Casciotti KL Dehairs F Elskens M Honda M Karl DM Siegel DA Silver MW Steinberg DK Valdes J Van Mooy B Wilson S 《Science (New York, N.Y.)》2007,316(5824):567-570
The oceanic biological pump drives sequestration of carbon dioxide in the deep sea via sinking particles. Rapid biological consumption and remineralization of carbon in the "twilight zone" (depths between the euphotic zone and 1000 meters) reduce the efficiency of sequestration. By using neutrally buoyant sediment traps to sample this chronically understudied realm, we measured a transfer efficiency of sinking particulate organic carbon between 150 and 500 meters of 20 and 50% at two contrasting sites. This large variability in transfer efficiency is poorly represented in biogeochemical models. If applied globally, this is equivalent to a difference in carbon sequestration of more than 3 petagrams of carbon per year. 相似文献