Lymphosarcoma with hypercalcemia and osteolysis in a dog

Lymphosarcoma in a six year old male Doberman pinscher was accompanied by hypercalcemia, generalized osteolysis and renal calcification. Tumor involvement of bone marrow was extensive. The possible pathogenesis of hypercalcemia was thought to be the result of a locally active bone-resorbing factor secreted by the tumor cells.     

Sarcocystis spp. infections in naturally infected cats and dogs: levels of sporocyst production and the influence of host, environmental and seasonal factors on the prevalence of infection

Data obtained from faecal samples from 508 domestic cats and 481 dogs, previously found to have a high frequency of Sarcocystis spp. infections, were further examined to provide information on levels of sporocyst shedding and to ascertain the influence of host, environmental and seasonal factors on the prevalence of naturally acquired infections. Statistical analysis of prevalence data revealed that, of the factors examined, only host age in cats exerted any apparent influence. Infections were significantly more common in cats up to, rather than over, 6 months of age. Although they tended to be greater in dogs than cats, faecal sporocyst counts in both hosts were generally low, with the majority of infected samples containing 200 sporocysts per gram or less. In infected dogs the highest count recorded was 144,600/g with a mean of 2270/g, and in infected cats it was 11,100/g with a mean of 597/g.     

Oxfendazole resistance in Nematodirus spathiger

The occurrence of anthelmintic resistance in a field strain of Nematodirus spathiger is reported for the first time. In a controlled anthelmintic trial with naturally-acquired infections, oxfendazole at 5 mg/ kg and levamisole at 8 mg/kg were 0 and 86% effective respectively, against this strain.     

Membrana nictitans gland cyst in a dog

A cyst involving the gland of the 3rd eyelid was removed from an 8-year-old dog. Clinically the circumscribed mass resembled a pigmented neoplasm. Histologically the cyst was multiloculated, with homogeneous eosinophilic periodic acid-Schiff-positive content. Melanin pigment was present in epithelial cells and cystic lumens. Protective functions of the 3rd eyelid were retained following excisional biopsy.     

Field trials with a bivalent vaccine (HVT and SB-1) against Marek's disease

White leghorn chickens on five farms were given a bivalent Marek's disease (MD) vaccine consisting of turkey herpesvirus (HVT) and SB-1 (a nononcogenic MD virus); other chickens received only HVT. The farms had histories of "vaccination failures," presumably owing to an exceptionally virulent challenge MD virus. The bivalent vaccine uniformly protected chickens better than HVT alone between 12 and 16-20 weeks of age, when serious MD losses occurred. During that period, total mortality in groups given both viruses ranged from 0.39 to 1.26% (mean 0.86%), whereas that in HVT-vaccinated groups not exposed to SB-1 varied from 1.92 to 7.44% (mean 3.43%). Chickens in pens or rows with close contact to those given bivalent vaccine also had low MD mortality rates (0.46-1.06%, mean 0.77%), probably from the spread of SB-1.     

A note on the structure and iron‐binding properties of egg‐shell membranes

1. When a solution of ferric ammonium sulphate was added to shell membranes of the domestic fowl, iron infiltrated the mantle (cortex) surrounding the cores of the individual fibres of the membranes.

2. Contraction of warm eggs in ice‐cold colloidal iron caused flooding of pore canals and contamination of the underlying shell membranes with this element.

3. Appreciable contamination of the inner shell membrane with iron persisted for 25 d in infertile eggs stored at 37.5 °C.