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11.
Akinori Hirashima Manabu Matsushita Kentaro Nakazono Morifusa Eto 《Pesticide biochemistry and physiology》2006,85(1):15-20
Effects of 1-arylimidazole-2(3H)-thiones (AITs) and 1-(substituted benzyl)imidazole-2(3H)-thiones (BITs) were tested on progeny formation in Drosophila melanogaster. Some AITs showed inhibitory activities at laying eggs and delayed eclosion by 1 day. The inhibitory activity was nullified by adding octopamine (OA) or noradrenaline (NA) to the medium for progeny formation in D. melanogaster. The effect of AIT on the contents of OA and NA was analyzed in adults of D. melanogaster by high-performance liquid chromatography with electrochemical detection. Flies fed with AIT decreased OA and NA levels and increased TA content. Taken together, the inhibitory activity of AIT could be due to inhibition of tyramine β-hydroxylase and dopamine β-hydroxylase. 相似文献
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Kuniyoshi Shimizu Shoko Fukunaga Keisuke Yoshikawa Ryuichiro Kondo 《Journal of Wood Science》2007,53(2):153-160
The effects of 120 methanol extracts prepared from bark and heartwood of 69 types of Japanese wood on the melanin production
of B16 melanoma cells were examined. The melanin content of B16 melanoma cells was determined spectrophotometrically at 405nm.
The extracts were also examined for their effects on cell viability. We found that the methanol extracts of Fagus crenata (buna, wood, 100μg/ml), Sapium sebiferum (Nankinhaze, wood, bark, 10μg/ml), and Zelkova serrata (keyaki, wood, 10μg/ml) greatly inhibited the melanin production of B16 melanoma cells without significant cytotoxicity.
However, these extracts did not inhibit tyrosinase activity at the concentration of 100μg/ml. These findings indicate that
the depigmenting mechanism of these extracts involves the suppression of some pigmenting signals in stimulating melanogenesis
rather than the inhibition of tyrosinase activity.
Part of this study was presented at the 53rd Annual Meeting of the Japan Wood Research Society, Fukuoka, Japan, March 2003 相似文献
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Establishment of a Model of Spontaneously-Running-Tokushima-Shikoku Rats with Left Atrial Thrombosis
Takamasa Ohnishi Fumiko Hisaoka Masaki Morishima Akira Takahashi Nagakatsu Harada Kazuaki Mawatari Hidekazu Arai Emiko Yoshioka Satomi Toda Izumi Keisuke Yutaka Nakaya 《Journal of toxicologic pathology》2014,27(1):51-56
Studies that investigate the underlying mechanisms of disease and treatment options typically require the use of a suitable animal model. Few suitable animal models exist for left atrial thrombosis. Here, we demonstrated that the Spontaneously-Running-Tokushima-Shikoku (SPORTS) rat — a Wistar strain known for its running ability—is predisposed to the development of thrombi in the left atrium. We investigated the incidence of left atrial thrombosis in male (n = 16) and female (n = 17) SPORTS rats and observed organized atrial thrombosis in 57% and 38% of males and female rats, respectively. In the male rats, systolic blood pressures and heart rates were significantly higher in SPORTS rats than in control Wistar rats. We could not find any evidence of arrhythmias, such as atrial fibrillation, during electrocardiographic examination of SPORTS rats. We believe that the SPORTS rat could serve as a new research model for left atrial thrombosis; further, it may be suitable for research investigating the development of new antithrombotic approaches for the control of atrial thrombosis or familial thrombophilia in humans. 相似文献
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Accumulation of organotin compounds and marine birnavirus detection in Korean ascidians 总被引:1,自引:0,他引:1
Kaoru Azumi Shinji Nakamura Shin-Ichi Kitamura Sung-Ju Jung Keisuke Kanehira Hisato Iwata Shinsuke Tanabe Satoru Suzuki 《Fisheries Science》2007,73(2):263-269
ABSTRACT: Recently, a serious disease spread extensively in aquaculture sites of the ascidian Halocynthia roretzi in Korea. To understand circumstances of ascidians in Korean aquaculture sites, residue levels of organotin compounds were analyzed, and detection of a marine birnavirus (MABV) in tissues of H. roretzi was attempted. Korean H. roretzi showed high concentrations of butyltins (mono, di, and tributyltins), especially in the gill, hepatopancreas, and digestive tract. However, there was no significant difference in the residues of butyltins in the hepatopancreas between diseased and non-diseased ascidians. The positive rate of MABV detection was high in the hepatopancreas, but also no significant difference was observed between diseased and non-diseased individuals. These observations suggest that an accumulation of tributyltin and a latency of MABV in H. roretzi tissues does not directly relate to the occurrence of the disease. 相似文献
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Yunting?FangEmail author Per?Gundersen Rolf?D.?Vogt Keisuke?Koba Fusheng?Chen Xi?Yun?Chen Muneoki?Yoh 《Journal of Forest Research》2011,16(5):341-350
Data have been compiled from published sources on nitrogen (N) fluxes in precipitation, throughfall, and leaching from 69
forest ecosystems at 50 sites throughout China, to examine at a national level: (1) N input in precipitation and throughfall,
(2) how precipitation N changes after the interaction with canopy, and (3) whether N leaching increases with increasing N
deposition and, if so, to what extent. The deposition of dissolved inorganic N (DIN) in precipitation ranged from 2.6 to 48.2 kg N ha−1 year−1, with an average of 16.6 kg N ha−1 year−1. Ammonium was the dominant form of N at most sites, accounting for, on average, 63% of total inorganic N deposition. Nitrate
accounted for the remaining 37%. On average, DIN fluxes increased through forest canopies, by 40% and 34% in broad-leaved
and coniferous forests, respectively. No significant difference in throughfall DIN inputs was found between the two forest
types. Overall, 22% of the throughfall DIN input was leached from forest ecosystems in China, which is lower than the 50–59%
observed for European forests. Simple calculations indicate that Chinese forests have great potential to absorb carbon dioxide
from the atmosphere, because of the large forest area and high N deposition. 相似文献