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31.
Ala’a F. Eftaiha Nidal Qinna Iyad S. Rashid Mayyas M. Al Remawi Munther R. Al Shami Tawfiq A. Arafat Adnan A. Badwan 《Marine drugs》2010,8(5):1716-1730
Metronidazole, a common antibacterial drug, was incorporated into a hydrophilic polymer matrix composed of chitosan xanthan gum mixture. Hydrogel formation of this binary chitosan-xanthan gum combination was tested for its ability to control the release of metronidazole as a drug model. This preparation (MZ-CR) was characterized by in vitro, ex vivo bioadhesion and in vivo bioavailability study. For comparison purposes a commercial extended release formulation of metronidazole (CMZ) was used as a reference. The in vitro drug-release profiles of metronidazole preparation and CMZ were similar in 0.1 M HCl and phosphate buffer pH 6.8. Moreover, metronidazole preparation and CMZ showed a similar detachment force to sheep stomach mucosa, while the bioadhesion of the metronidazole preparation was higher three times than CMZ to sheep duodenum. The results of in vivo study indicated that the absorption of metronidazole from the preparation was faster than that of CMZ. Also, MZ-CR leads to higher metronidazole Cmax and AUC relative to that of the CMZ. This increase in bioavailability might be explained by the bioadhesion of the preparation at the upper part of the small intestine that could result in an increase in the overall intestinal transit time. As a conclusion, formulating chitosan-xanthan gum mixture as a hydrophilic polymer matrix resulted in a superior pharmacokinetic parameters translated by better rate and extent of absorption of metronidazole. 相似文献
32.
Shirin Karimi Abdolreza Mohamadnia Seyed Alireza Nadji Reza Yadegarazari Adnan Khosravi Naghmeh Bahrami Massoud Saidijam 《Iranian Biomedical Journal》2015,19(1):17-22
Introduction: Although extensive research has been conducted on lung cancer markers, a singular clinically applicable marker has not been found yet. The objective of this study was to evaluate the sensitivity and the specificity of carcinoembryonic antigen (CEA) mRNA and lung-specific X protein (LUNX) mRNA biomarkers in peripheral blood to detect lung cancer individually and simultaneously. Methods: Thirty patients affected by lung cancer and 30 healthy individuals were studied in this research. Three vials of cDNA were made from each sample after taking peripheral blood samples and extracting total RNA. Each sample was examined by the real-time RT-PCR technique. The result from each vial was then compared with the sensitivity of overall marker. Results: The CEA mRNA was positive in 24 out of 30 lung cancer patients. Hence, its sensitivity was determined at 80%, differing significantly from that observed in healthy individuals, where 11 positive cases were seen. The overall sensitivity of this marker was significantly associated with positivity in vials 2 and 3 but not in vial 1. The LUNX mRNA was positive in 21 out of 30 patients, indicating 70% sensitivity. This finding significantly differed from that in healthy individuals. The overall sensitivity of this marker was significantly associated with positivity in vials 1 and 3, but not in vial 2. In 93.3% of the patients, at least one positive marker was observed. Conclusion: The mentioned mRNA could be suggested as sensitive and specific markers in peripheral blood for primary diagnosis of lung cancer.Key Words: Lung neoplasms, RNA, Carcinoembryonic antigen, Sensitivity and specificity 相似文献
33.
Khalid A. Ibrahim Bassam I. El-Eswed Khaleel A. Abu-Sbeih Tawfeeq A. Arafat Mahmoud M. H. Al Omari Fouad H. Darras Adnan A. Badwan 《Marine drugs》2016,14(8)
An increasing interest has recently been shown to use chitin/chitosan oligomers (chito-oligomers) in medicine and food fields because they are not only water-soluble, nontoxic, and biocompatible materials, but they also exhibit numerous biological properties, including antibacterial, antifungal, and antitumor activities, as well as immuno-enhancing effects on animals. Conventional depolymerization methods of chitosan to chito-oligomers are either chemical by acid-hydrolysis under harsh conditions or by enzymatic degradation. In this work, hydrolysis of chitosan to chito-oligomers has been achieved by applying adsorption-separation technique using diluted HCl in the presence of different types of zeolite as adsorbents. The chito-oligomers were retrieved from adsorbents and characterized by differential scanning calorimetry (DSC), liquid chromatography/mass spectroscopy (LC/MS), and ninhydrin test. 相似文献
34.
The removal of nitrate reductase phosphorylation enhances tolerance to ammonium nitrogen deficiency in rice 下载免费PDF全文
HAN Rui-cai XU Zhi-rong LI Chen-yan Adnan RASHEED PAN Xiao-hua SHI Qing-hua WU Zi-ming 《农业科学学报》2022,21(3):631-643
Nitrate reductase(NR) is a key enzyme for nitrogen assimilation in plants, and its activity is regulated by posttranslational phosphorylation. To investigate the effects of dephosphorylation of the NIA1 protein on the growth and the physiological and biochemical characteristics of rice under different forms of nitrogen supplies, the phenotypes, nitrogen metabolism and reactive oxygen metabolism were measured in NIA1 phosphorylation site-directed mutant lines(S532 D and S532 A), an Os Nia1 over-e... 相似文献
35.
Cheng Chen Yang Xiuxia Wang Jianjun Luo Kang Rasheed Adnan Zeng Yongjun Shang Qingyin 《Paddy and Water Environment》2020,18(1):99-109
Paddy and Water Environment - To clarify the effect of water management on global warming potential and crop yield with rice straw returning in typical double-rice cropping systems, a field... 相似文献
36.
Saban Kordali Ahmet Cakir Tulay Aytas Akcin Ebru Mete Adnan Akcin Tuba Aydin Hamdullah Kilic 《Industrial Crops and Products》2009,29(2-3):562-570
The chemical composition of essential oils isolated by hydrodistillation from the aerial parts of Achillea gypsicola Hub-Mor., Achillea biebersteinii Afan. and n-hexane extracts obtained from the flowers of A. gypsicola and A. biebersteinii Afan. was analyzed by GC and GC–MS. Camphor (40.17–23.56%, respectively), 1,8-cineole (22.01–38.09%, respectively), piperitone (11.29–0.37%, respectively), borneol (9.50–5.88%, respectively) and α-terpineol (1.56–5.15%, respectively) were found to be the main constituents in A. gypsicola and A. biebersteinii essential oils. Furthermore, hexane extracts of A. gypsicola and A. biebersteinii consist of mainly camphor (37.78–27.88%, respectively), 1,8-cineole (13.43–24.78%, respectively), piperitone (15.57%-tr, respectively), n-eicosane (1.61–9.68%, respectively), n-heneicosane (2.56–9.55%, respectively), n-tricosane (3.46–10.04%, respectively), linoleic acid (6.19–3.17%, respectively) and borneol (5.66–5.58%, respectively). Although the oils and extracts were characterized relatively by high content of oxygenated monoterpenes, hexane extracts of the plant samples relatively rich in n-alkanes, fatty acids and fatty acid esters as compared with the oil. The oils and hexane extracts were also tested against 12 phytopathogenic fungi and the oils found to be more toxic as compared with hexane extracts of the plant samples. A. gypsicola oil only did not inhibit the growth of Fusarium graminearum. The extracts also strongly increased the growth of Fusarium equiseti and F. graminearum. Therefore, the antifungal activity of the oils can be attributed to their relatively high content of oxygenated monoterpenes. The results of herbicidal assays of the essential oils and hexane extracts of the plant samples against five important weeds in cultivated areas, Amaranthus retroflexus L., Chenopodium album L., Cirsium arvense L. (Scop.), Lactuca serriola L. and Rumex crispus L. showed that, in particular, the oils had inhibitory effects on the seed germination and seedling growth of A. retroflexus, C. arvense and L. serriola. The hexane extracts also showed lower herbicidal effect against the weeds in comparison to that of the oils. The findings of the present study suggest that the essential oils have a potential to be used as herbicide as well as fungicide. 相似文献
37.
Zahed A 《Science (New York, N.Y.)》2012,335(6072):1040-1041
38.
Adeel Sattar Mian Abdul Hafeez Qin Wu Adnan Hassan Tahir Muhammad Abu Bakr Shabbir Dongmei Chen Lingli Huang Shuyu Xie Zonghui Yuan 《Journal of veterinary pharmacology and therapeutics》2020,43(2):97-107
Cyadox (CYX) is a synthetic antibacterial agent of quinoxaline with much lower toxic effects. A safety criterion of CYX for clinical use was established by studying the pharmacokinetics and metabolism of CYX after oral (PO), intramuscular (IM), and intravenous (IV) administration. CYX was administered in six domesticated cats (three males and three females) by PO (40 mg/kg.b.w.), IM (10 mg/kg.b.w.), and IV (10 mg/kg.b.w.) routes in a crossover pattern. Highly sensitive liquid chromatography with ultraviolet detection (HPLC-UV) method was developed for detection of CYX and its metabolites present in plasma, urine, and feces. The bioavailability of CYX after PO and IM routes was 4.37% and 84.4%. The area under curves (AUC), mean resident time (MRT), and clearance (CL) of CYX and its metabolites revealed that CYX quickly metabolized into its metabolites. The total recovery of CYX and its main metabolites was >60% after each route. PO delivery suggesting first pass effect in cats that might make this route suitable for intestinal infection and IM injection could be better choice for systemic infections. Less ability of glucuronidation did not show any impact on CYX metabolism. The findings of present study provide detailed information for evaluation of CYX. 相似文献
39.
Abrar Muhammad Mohsin Xu Hu Aziz Tariq Sun Nan Mustafa Adnan Aslam Muhammad Wajahat Shah Syed Atizaz Ali Mehmood Khalid Zhou Baoku Ma Xingzhu Chen Xianni Xu Minggang 《Journal of Soils and Sediments》2021,21(2):705-723
Journal of Soils and Sediments - Soil organic carbon (SOC) is an important parameter determining soil fertility and sustaining soil health. How C, N, and P contents and their stoichiometric ratios... 相似文献
40.
This article presents a comprehensive review of the literature on microwave wood testing, offering a critical comparison of
reported methods and techniques. The purpose of this review is to establish current achievements and evaluate the potential
for the application of microwave methods in industry. All reviewed articles are classified based on the way they deal with
four key issues: propagation modeling, measurement technique, hardware implementation, and determination of wood properties.
Currently used methods for propagation modeling are considered first, with particular attention given to the calculation of
propagation factors along the principal directions, because these methods take into consideration wood anisotropy and allow
grain angle detection. Measurement techniques are also considered in more detail, with a qualitative comparison of the two
most advanced techniques: the focused beam technique and the modulated scattering technique. Reported hardware implementation
and methods for determining the wood properties of interest from measured data are reviewed in the final sections. The technology
is mature, but more effort is needed to reach a solution suitable for an industrial environment. This article aims to help
researchers in this field to identify the remaining issues. 相似文献