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排序方式: 共有109条查询结果,搜索用时 15 毫秒
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Abstract CASE HISTORY: In 2008, six lambs within a flock of Dorpercross sheep were born with musculoskeletal and neurological disease. Clinical signs included hindlimb weakness, and urinary incontinence. CLINICAL FINDINGS: All lambs had focal, inverted areas of alopecic skin over the caudal sacrum, and short, often kinked tails. Four affected lambs were subject to euthanasia, and necropsied. On gross examination, the arches of sacral vertebrae were absent, and spinal nerves and meninges were adherent to the overlying subcutis. Other gross lesions included narrow, elongated skulls, herniation of the occipital lobes into the caudal fossas, hydrocephalus, and syringomyelia. One lamb had coning of the cerebellar vermis, but cerebellar herniation through the foramen magnum was not identified. DIAGNOSIS: Spina bifida, with associated malformations of the central nervous system. CLINICAL RELEVANCE: Examination of breeding records suggested either an autosomal recessive or partially penetrant autosomal dominant pattern of inheritance. Because of the associated tail lesions it is proposed that the pathogenesis of this syndrome involves a defect in development of the tail bud (secondary neurulation), that tethering of the spinal cord resulted in the clinical signs, and abnormal pressure of the cerebral spinal fluid resulted in the defects in the skull and brain. 相似文献
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Abstract Extract Sir:— In the recent letter from N. Inglis,(1) an infection by Leptospira icterohaemorrhagiae in deer is postulated on the basis of serological evidence. Results of antibody testing with other serovars of Leptospira would be most informative and would reveal cross-reactions, which are known to occur freyuently. Further, the strain of L. icterohaemorrhagiae antigen and the type of test used would be of great interest to readers. Seroconversion to L. icterohaemorrhagiae serovar copenhageni, has been well documented since 1951.(2) 相似文献
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Polymerase chain reaction and other laboratory techniques in the diagnosis of long incubation rabies in Australia 总被引:3,自引:0,他引:3
KA MCCOLL AR GOULD PW SELLECK PT HOOPER HA WESTBURY JS SMITH† 《Australian veterinary journal》1993,70(3):84-89
SUMMARY Blood and post-mortem tissues from a 10-years-old girl were submitted to the Australian Animal Health Laboratory. Clinical signs and histopathological lesions had suggested a diagnosis of rabies, but, an unusually long incubation period of at least 5 years did not encourage such a diagnosis. Serological examinations by the rapid fluorescent focus inhibition test revealed a dramatic increase in rabies virus-neutralising antibody during the 10-day period of hospitalisation. The results of a fluorescent antibody test on brain smears, and an immunoperoxidase test on formalin-fixed sections of brain were also consistent with a diagnosis of rabies. Attempts to isolate virus were unsuccessful. Polymerase chain reactions (PCRs) were conducted on a 10% suspension of a post-mortem sample from the patient's brain, using primers based on the published sequence of the Pasteur virus strain of rabies virus. 413 and 513 bp fragments from the nucleoprotein gene and a 403 bp fragment from the glycoprotein gene were amplified. Subsequent sequencing of these fragments, and comparison with equivalent regions of known rabies viruses, confirmed that the fragments originated from a virus belonging to the rabies virus serotype. This case demonstrated the advantage of using a range of laboratory techniques to obtain a definitive diagnosis. In particular, a PCR-based test may allow a diagnosis, even in the face of conditions that preclude virus isolation such as apparently occurred in this case. Finally, this case demonstrated that an unusually long incubation period should not discourage a tentative clinical diagnosis of rabies. 相似文献
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In humans it has been estimated that for each 2.5 g L–1 decrease in serum albumin, risk of death increases by 24–56%. Clinical impression suggests this may be similar in veterinary patients. Species‐specific albumin (plasma) is often unavailable and concentrated solutions are not. Our experience using 25% human serum albumin (HSA) in critically ill dogs suggests a positive effect (results submitted), however it is expensive. Bovine serum albumin (BSA) may be a more cost effective and readily available alternative. The purpose of this study was to assess the immediate and long‐term safety of an intravenous dose (500 mg kg–1) of bovine albumin administered to healthy dogs. Ten mature dogs (eight males, two females, 28 ± 6 kg) were to receive BSA (250 mg mL–1) twice (BSA1 and BSA2) with 14 days between treatments. Temperature, blood pressure, and pulse and respiration rate were continuously monitored to identify a reaction to BSA. All dogs received BSA1. One dog immediately developed mild urticaria and pruritus, otherwise the infusion was well tolerated. No immediate reaction was noted in the other nine dogs. Two dogs received BSA2. One dog developed a mild immediate reaction similar to that occurring with BSA1, and one dog (the dog immediately reacting to BSA1) developed a severe anaphylactic reaction. Due to these reactions, no other dogs received BSA2. During a two‐week observation of the remaining eight dogs given BSA1, five developed a mild or severe generalized type‐III hypersensitivity reaction. The dog experiencing a mild reaction during BSA2 administration also developed a generalized type‐III hypersensitivity reaction. Delayed reactions occurred 15 ± 2.7 days after BSA exposure. Three dogs did not develop a reaction. All reacting dogs recovered fully. The severity of reactions, and the number of dogs affected, suggests prior (natural) exposure and immunological sensitization to bovine albumin. Bovine serum albumin is not suitable for therapeutic use in dogs. 相似文献
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JC Hess KA Grimm GJ Benson WA Tranquilli R Sarr 《Veterinary anaesthesia and analgesia》2005,32(4):18-18
The green iguana, Iguana iguana, is used as a model in reptile anesthesia research because of its size, availability, and the body of knowledge characterizing its physiology. Arterial blood gas values in nonanesthetized green iguanas have not been determined because of the technical difficulty involved. Vascular access port (VAP) placement to facilitate blood sampling has been described in other species, but not lacertilians. This abstract describes the technique for placement of VAPs and the values for arterial blood gas parameters in seven 1 kg adult green iguanas. Using sterile technique, a 1.5 cm incision was made on the lateral side of the neck. Blunt dissection ventral to the external jugular vein revealed the internal and external carotid arteries near their bifurcation. The catheter was inserted into the internal carotid artery and then guided to the common carotid artery. The other end of the catheter was tunneled below the skin to a subcutaneous location, caudal‐dorsal to the iSPSilateral scapula. The skin was closed and the port was flushed twice a week with heparinized saline. Post‐operatively, the VAPs were well tolerated by the iguanas. Difficulties included port disconnection (n = 1), inability to aspirate blood after a few weeks (n = 2), and infection (n = 1). The iguanas were breathing room air prior to and during blood collection. From the five functional VAPs, the blood pH, PCO2, PO2, HCO‐3, and BE (measured at 37 °C) were 7.45 ± 0.06; 37.5 ± 7.0 mm Hg, 99.0 ±16.6 mm Hg, 25.4 ± 2.5 mmol L–1, and 1.5 ±2.4 mmol L–1 respectively (mean ± SD). VAPs can be successfully used to facilitate collection of arterial blood gas samples in green iguanas. These values are similar to those reported for most mammalian species. This technique should facilitate research in anesthesiology and respiratory physiology of iguanas and other lacertilians. 相似文献
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