右美托咪定抑制NOX4缓解急性应激致大鼠肾损伤

本研究拟探索右美托咪定（dexmedetomidine,DEX）对大鼠急性应激致肾损伤的保护作用,并从氧化应激的角度探索DEX对大鼠肾的保护通路。本研究使用了急性束缚应激模型,其中,大鼠被迫游泳15 min,并束缚3 h。本试验采用生化检测、组织病理学切片观察以评估肾功能,然后测定了氧化应激以及氧化应激的相关通路蛋白。旷场试验证实成功建立了急性应激模型。急性应激引起的肾损伤增加了NOX4,降低了Nrf2/HO-1/NQO1表达水平。DEX可降低NOX4表达,同时升高Nrf2/HO-1/NQO1的表达水平。DEX治疗组与急性应激组相比的肾生化结果明显恢复正常,病理切片观察损伤显著降低。试验结果表明,DEX治疗急性应激可影响NOX4/Nrf2/HO-1/NQO1信号通路,并抑制氧化应激。因此,DEX对急性应激引起的肾损伤具有保护作用,并在应激综合征中具有潜在的临床应用。     

土质边坡稳定安全系数影响因素的

土质边坡稳定安全系数的计算值主要与采用的简化计算方法和土工参数有关。采用正交试验法计算分析了不同的计算方法、材料参数、水位及其相关荷载、地震作用等对边坡安全系数计算值的影响，进而对设计中的计算方法和材料参数提出了一些有益的建议，并提出了在工程运行管理中应尽量避免低水位或水位骤降情况的意见，为土石坝类工程的设计与运行管理提供了重要参考。     

Penetration behavior of bath induced by top-blown gas jets for steelmaking converter

The cavity induced by top-blow gas jets impinging on the bath surface is one of most important parameters, which has overwhelming influence on the rate of slag formation and metallurgical performance. Water model experiments are conducted through a 1/10 scaled-down top-blown convertor. Effects of lance height and gas flow rate on penetration behavior are studied, and also the influence mechanism of liquid surface tension on penetration depth is addressed based on the experiments and theory analysis. An energy utilization index (EUI) is defined to reflect how much the impinging kinetic energy of gas jets are transferred into bath for formation of cavity, and an improved model is proposed to predict penetration depth of jets. The results show that penetration depth increases with lowering lance height and increasing gas flow rate, and impact diameter increases with increasing lance height, but is little affected by gas flow rate. Influence of liquid surface tension on penetration depth is enhanced with increasing surface tension and penetration depth. The EUI increases with increasing lance height, and a function relationship of it with lance height is obtained based on the experiments.     

Study on DAQ System by Using LabVIEW

Dong village is very valuable for research work because of its special regional and national character and rich cultural implication. In this paper, some information about the location, form and features of Dong village is given. Then, the relationship between the culture and the settlement is analyzed, which provides a clue for understanding Dong village and will be beneficial to creating modern human settlements.     

Seismic Behavior of Asymmetric Building under Pushover Analysis

Pushover analysis is a tool to study the inelastic behavior of structures under strong seismic action. The 3D-pushover analysis was performed to analyze the inelastic lateral-torsional coupled response of multistory asymmetric structures. The symmetric frame and frame-wall systems were studied in this paper, and the capability curve of the top displacement and base shear,the story drift and the position of rotation center were compared with reference to corresponding symmetric structures. The characters of inelastic response of multistory asymmetric structures were found. The conclusion provides reference for performance-based seismic design of asymmetric structures.     

香软米水稻品种云粳29号的提纯复壮与繁育技术

云粳29号是云南省农业科学院粮食作物研究所选育的常规粳稻香软米新品种,2011年3月通过云南省农作物品种审定委员会审定。该品种早熟、米质优、产量高、抗倒伏、抗稻瘟病和白叶枯病,其米饭香浓,柔软可口、外观油润光泽、冷不回生、商品性好。为进一步促进该品种推广应用,保持其优质、高产特性,防止混杂、退化,经过不断探索和研究,提出了优质种子提纯复壮与繁育技术。     

饲草压捆机压缩机构有限元分析

为了牧草资源的合理匹配,推动饲草产业化进程,进行了饲草压捆机设计与研制。在设计中将先进的工业设计软件Pro/Engineer和ANSYS有限元分析软件有机结合,对压捆机的关键机构——压缩机构进行了建模和结构分析,优化了结构设计,提高了设计的可行性,增加了农机设计的科技含量。     

基于圆盘渗透仪常用计算模型的比较和分析

圆盘渗透仪已成为一种常用的田问测定土壤导水参数的仪器，基于圆盘渗透仪在某一选定点测量的入渗时间以及与入渗时间相对应的入渗量，利用一些常用的计算模型来计算低基模吸力土壤表层的导水参数，如吸水系数、导水率和宏观毛管上升高度等。本研究在总结一些常用的计算模型的基础上，并结合实验和模拟的数据对其进行比较和分析，为利用圆盘渗透仪进行土壤水力特性的估算提供了一定的参考作用。     

弧形钢闸门抗滑稳定可靠性分析

以弧形钢闸门自重、静水压力、闸墩及护坡自重、闸墩基础与地基间的摩擦系数和基底粘着力等因素作为随机变量,探讨了弧形钢闸门抗滑稳定可靠性分析方法,建立了抗滑稳定极限状态方程。结合工程实例对弧形钢闸门抗滑稳定可靠性进行了定量分析,可靠性指标b为4.1688,失效概率Pf为6.717×10-5,并与传统的容许应力法作了比较。结果表明,该方法更科学、更合理、更具有实际意义。