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991.
GUAN Cang-hai ZHAO Yu-qiao Guo Liang CHEN Yu-Zhu WANG Wei-Na JIANG Xing-ming 《园艺学报》2000,36(10):1908-1912
MNX1 antisense RNA 1 (MNX1-AS1) is a newly discovered long non-coding RNA (lncRNA), which is highly dysregulated in various carcinomas and its expression level is closely related to the overall survival and prognosis of patients. MNX1-AS1 regulates the occurrence and development of carcinomas by endogenous competitive adsorption of miRNA, regulating cell cycle, inducing epithelial mesenchymal transformation and activating multiple signaling pathways. The in-depth study of the carcinogenesis of MNX1-AS1 is useful for the early diagnosis, targeted therapy and prognostic assessment of relevant carcinomas. This article reviews the roles of MNX1-AS1 in malignant tumor. 相似文献
992.
JIN Bei-fang LU Qin-zhen ZHANG Yan CUI Ya-lan QIANG Zheng LIAO Man-xi TAN Hui-yuan LIU Fang 《园艺学报》2000,36(9):1625-1630
AIM To explore the effects of oxidative stress and inflammatory response on kidney injury induced by hyperthyroidism in mice. METHODS Forty male Kunming mice were randomly divided into control group (n =20) and L-thyroxine (T4) group (n =20). The mice in T4 group were intraperitoneally injected with T4 diluent at a dose of 1 mg/kg to induce hyperthyroidism, and those in control group were injected with normal saline of the same volume. After 7 weeks, the mice were weighed and dissected, the kidneys were removed and weighed, and the length of tibia was also measured. The activity of superoxide dismutase (SOD) and the content of malondialdehyde (MDA) in the kidney tissues were detected. The pathological changes of the kidney tissues were observed by HE staining. The levels of 4-hydroxynonenal (4-HNE)-modified proteins, interleukin-1 receptor-associated kinase 1 (IRAK1) and tumor necrosis factor receptor-related factor 6 (TRAF6) were determined by Western blot and immunohistochemistry. RESULTS Compared with control group, the body weight of the mice was decreased, while the kidney size and weight were increased significantly in T4 group. In addition, the ratios of kidney weight/body weight and kidney weight/tibia length were also increased (P <0.05). In T4 group, the renal tubules were enlarged, and the epithelial cells of renal tubules were swollen and exfoliated, with vacuolar degeneration. Furthermore, reduced SOD activity, and increased MDA content and 4-HNE-modified proteins were found in T4 group, all of which were related to oxidative stress (P <0.05). The levels of inflammation-related proteins IRAK1 and TRAF6 were significantly increased in T4 group (P <0.05). CONCLUSION Excessive T4 may lead to kidney hypertrophy and injury in mice, and the mechanism may be related to oxidative stress and inflammatory response. 相似文献
993.
QIAN Wei LOU Guo-qiang ZHOU Zhuo-lin WANG Jia LIU Xiu-jie HAO Mao-lin WANG Wan-tie 《园艺学报》2000,36(11):2056-2061
AIM To investigate the role of curcumin (CUR) in lung ischemia/reperfusion (I/R) injury (LIRI) and its relationship with autophagy. METHODS 40 SD rats were randomly divided into sham operation (sham) group, I/R group, solvent (DMSO) group, CUR group and CUR+rapamycin (CUR-Rap) group. The rats were intraperitoneally injected with normal saline, DMSO, CUR or CUR+Rap before operation. After the rat LIRI model was established, the lung tissues were taken to measure W/D, TLW, IAR, and the contents of SOD and MDA were also measured to indicate the oxidative stress level. Light and electron microscopes were used to observed the morphology and ultrastrucure of lung tissues. The expression levels of autophagy-related proteins were determined by Western blot to evaluate autophagy levels. RESULTS Compared with sham group, wet weight/dry weight (W/D), total lung water (TLW), injured alveoli rate(IAR) and malondialdehyde (MDA) content in all other groups were increased, superoxide dismutase (SOD) activity was decreased, the levels of autophagy were increased (P <0.05), and lung tissue injury and cell ultrastructural damage were aggravated in CUR group. Compared with DMSO group, W/D, TLW and IAR and MDA content were decreased, SOD activity was decreased, autophagy levels were also decreased (P <0.05), and lung tissue and cell ultrastructural damage were attenuated. Compared with CUR group, W/D, TLW, IAR and MDA content were increased, SOD activity declined, the autophagy levels were increased (P <0.05), and damage of lung tissues and cells were more serious in CUR-Rap group. CONCLUSION Curcumin attenuates the lung I/R injury in rats, and its mechanism may be related to the reduction of oxidative stress and the inhibition of autophagy. 相似文献
994.
995.
不结球白菜维生素C和可溶性糖含量的遗传分析 总被引:14,自引:1,他引:13
采用主基因—多基因混合遗传模型分析方法,对不结球白菜乌塌菜×矮脚黄、雪克青×矮脚黄两个组合的维生素C、可溶性糖含量进行单世代和联合世代遗传分析。结果表明,两组合中维生素C含量遗传符合一个主基因和多基因的混合遗传模型,主基因遗传率为5268%~7412%。可溶性糖在雪克青×矮脚黄组合中也符合主基因—多基因遗传模型,主基因遗传率为8973%~8979%。维生素C和可溶性糖主基因效应均以加性效应为主,在乌塌菜×矮脚黄组合中,两性状主基因有较明显的负向显性效应,在雪克青×矮脚黄组合中,显性效应不明显。育种实践中应注重对主基因加性效应的利用。 相似文献
996.
997.
998.
在害虫发生初期减少农药防治次数能明显降低害虫发生后期的防治难度,5月底前收获的小白菜宜防治1次,在害虫发生盛期种植的小白菜,宜防治2次。 相似文献
999.
1000.
松口蘑的半人工及人工驯化栽培 总被引:3,自引:0,他引:3
论述了松口磨的适应性和驯化潜能, 介绍了松口蘑半人工栽培的基本方法并进行评估, 分析了应用纯培养菌种人工栽培松口蘑的难点和关键问题, 提出了松口蘑人工驯化栽培的技术路线。 相似文献