Doxorubicin affects the cardiac muscarinic system in the rat.

During the study on the mechanism of doxorubicin-induced cardiotoxicity, we observed that a long incubation (4 hr) with doxorubicin reduced the maximal negative inotropic effects of a muscarinic receptor agonist, carbachol. The mechanism responsible for this doxorubicin-induced reduction of the efficacy of carbachol was examined in isolated guinea pig hearts. In isolated left atrial muscle preparations, 1 hr incubation with 100 microM doxorubicin caused a parallel right-ward shift of the concentration-response curves for carbachol, but a longer (4 hr) incubation with this agent (30, 100 or 200 microM), caused a significant reduction of the magnitude of the negative inotropic effect of carbachol in addition to the concentration-dependent parallel right-ward shift. The 4-hr incubation with these concentrations of doxorubicin also reduced the maximal negative inotropic effect of an adenosine A1 receptor agonist, R-phenylisopropyl adenosine (R-PIA), without affecting the potency of this agonist. Doxorubicin (1 to 100 microM) reduced [3H]quinuclidinyl benzilate (QNB) binding in a concentration dependent manner, but failed to alter [3HIR-PIA binding. The decrease in the magnitude of the maximal negative inotropic effect by doxorubicin was caused by changes in the muscarinic system at steps common to the transduction of muscarinic and adenosine A1 receptor mechanisms.     

Acupuncture for general veterinary practice.

Since the International Society of Veterinary Acupuncture (IVAS) was founded in 1974, acupuncture (AP) has received greater acceptance by veterinary professionals throughout the world. This article introduces some important animal diseases that respond well to AP therapy. These include resuscitation of small animals, treatment of anoestrous gilts and sows, bovine reproductive disease, canine vertebral problems and equine backpain, etc. Conventional medicine considers these to be difficult cases to treat. Veterinarians have become more aware of the benefits of AP especially for those diseases, thanks to the efforts of experienced practitioners and scientists, and the many published reports on veterinary AP that have introduced some good indications for AP therapy in veterinary practice. Possible mechanisms behind the effectiveness of AP are discussed. This article aims to introduce veterinarians to good indications for AP to initiate their interest in the practice of AP. Although this is a rapidly expanding field, a long march must begin with one step. We wish this article to be the shoes for such a march. For more information on veterinary AP, contact IVAS , P.O. Box 1478, Longmont, CO.. 80502, USA (http://www.ivas.org), or your national veterinary acupuncture society (http://www.komvet.at/ ivadkom/vapsocs.htm).     

阔叶红松林的生物量和营养元素含量的研究

一、研究内容和方法我们于1985—1987年对小兴安岭阔叶红松林的生物量进行了研究。生物量的测定是在凉水自然保护区的阔叶红松林内进行的。林龄220年,组成8红2椴,林分平均高23.1m,平均直径37.4cm。其中红松平均高27.2m,平均直径45.2cm,密度622株/ha,针     

奶牛繁殖疾病的调控

本文综述了奶牛繁殖疾病的发病原因和调控措施，分析认为奶牛的营养状况是影响奶牛繁殖力的重要因素。理想的奶牛管理应做到整个泌乳期始终监测奶牛的体况和奶牛日粮中微量元素的维生素的含量，避免营养素的不平衡而引发的奶牛繁殖障碍，同时应避免奶牛过肥或过瘦。适当补充某些维生素和矿物质十分重要。     

我国城乡二元养老制度的建立及其负面影响

在历史上，我国一直实行家庭养老方式，新中国成立以后，我国建立了城乡二元的养老保障制度，改革开放后又强化了这一制度；城乡二元养老保障制度产生的后果十分严重，它的存在导致我国城乡差距进一步扩大，许多农村老人晚境凄惨，国民经济的持续稳定发展也受到了严重影响。     

从专门的“户”“商”“市”“税”看唐代商品性经济作物的生产

从经济作物领域中专业户的大量涌现、专门商人的日益活跃、专门市场的日趋繁荣和专门税的大量征收可以窥见唐代商品性经济作物的生产状况。在社会主义新农村建设的今天，对其研究仍具有十分深远的借鉴意义。     

水稻条纹病毒在玉米和水稻上流行差异分析

为了明确水稻条纹病毒(RSV)在水稻和玉米上发生程度差异明显的原因,从一个侧面了解RSV流行本质,2004年在洪泽进行田间试验。采用黄盘诱集、盘扑、盘刮、肉眼计数等方法比较武育粳3号和掖单13上灰飞虱侵入和消长动态,结果表明两者均只有一个成虫侵入高峰,单位面积迁入虫量前者是后者的3.6倍,单株平均虫量相近。Dot-ELISA法测定灰飞虱带毒率为40%,成虫迁移扩散高峰期22d内两者接毒量约为每天百株137头带毒虫。武育粳3号有二代若虫发生,掖单13则无。逐日调查发病进程,结果显示水稻发病率为60%,玉米为0。室内抗性鉴定,掖单13对RSV的抗性比武育粳3号高4个级别。综合以上结果,寄主品种抗性决定了RSV在水稻和玉米上流行状况,二代若虫重复侵染是RSV在水稻上重发的另一主要原因。     

应用极大似然法分析小麦穗长的遗传

采用质量—数量性状遗传的极大似然分析方法,对长穗小麦品系93(220)的主茎穗长进行了质量—数量遗传模型测验和主、微基因效应与变异估计。结果表明:长穗小麦新品系93(220)的主茎穗长为一典型的质量—数量性状,由一个主基因和若干微基因共同控制;一对隐性主基因控制穗长,附合加性——显性遗传模型,F1代表现为部分显性,隐性主基因增加主茎穗长的效应平均为1.47,微基因遗传效应为2.83cm,隐性主基因个体主茎穗长表现为长穗。     

浅谈种子质量保证

随着种子市场的规范化、商品化程度的提高,种子质量意识的大大增强,建立健全种子质量保障制度,全面保证种子质量,确保农民增产,农民增收势在必行。1质量就是生命对于种子这一特殊商品来说更是至关重要的,只有保障种子质量,才能使种子行业长久不衰。企业不能为了片面追求经济效益,生产经营伪劣种子,这样不仅降低了种子公司的信誉,而且给农民造成了经济损失。2要严格按照规程操作,严把质量关在种子生产过程中,确保亲本种子质量,尤其是纯度。应及时解决制种过程中花期不遇,制种产量低的技术难题,并认真开展种子田间检验及室内检验,确保种子的纯…     

银川地区羊肝中阿苯达唑(丙硫苯咪唑)残留情况的调查

阿苯达唑又称丙硫苯咪唑或丙硫咪唑，有时又称抗蠕敏，是目前国内常用的驱虫效果好、范围广、毒性较低的兽用驱虫药。随着家庭舍饲养羊规模的不断扩大，饲养者为了减少因寄生虫导致的死亡并增加育肥效果，常把阿苯达唑作为育肥前预防驱虫或寄生虫病治疗的首选药，出现了滥用或超剂量使用的现