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排序方式: 共有173条查询结果,搜索用时 15 毫秒
81.
Kjelstrup KB Solstad T Brun VH Hafting T Leutgeb S Witter MP Moser EI Moser MB 《Science (New York, N.Y.)》2008,321(5885):140-143
To determine how spatial scale is represented in the pyramidal cell population of the hippocampus, we recorded neural activity at multiple longitudinal levels of this brain area while rats ran back and forth on an 18-meter-long linear track. CA3 cells had well-defined place fields at all levels. The scale of representation increased almost linearly from <1 meter at the dorsal pole to approximately 10 meters at the ventral pole. The results suggest that the place-cell map includes the entire hippocampus and that environments are represented in the hippocampus at a topographically graded but finite continuum of scales. 相似文献
82.
Schemas and memory consolidation 总被引:1,自引:0,他引:1
Tse D Langston RF Kakeyama M Bethus I Spooner PA Wood ER Witter MP Morris RG 《Science (New York, N.Y.)》2007,316(5821):76-82
Memory encoding occurs rapidly, but the consolidation of memory in the neocortex has long been held to be a more gradual process. We now report, however, that systems consolidation can occur extremely quickly if an associative "schema" into which new information is incorporated has previously been created. In experiments using a hippocampal-dependent paired-associate task for rats, the memory of flavor-place associations became persistent over time as a putative neocortical schema gradually developed. New traces, trained for only one trial, then became assimilated and rapidly hippocampal-independent. Schemas also played a causal role in the creation of lasting associative memory representations during one-trial learning. The concept of neocortical schemas may unite psychological accounts of knowledge structures with neurobiological theories of systems memory consolidation. 相似文献
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Dunn JR Witter RL Silva RF Lee LF Finlay J Marker BA Kaneene JB Fulton RM Fitzgerald SD 《Avian diseases》2010,54(3):1038-1049
Marek's disease virus (MDV) is ubiquitous within commercial poultry flocks because current vaccines do not prevent MDV infection or transmission. In order for newly-evolved MDV strains to become established within a flock, it seems inevitable that any new strain would need to infect and replicate in chickens previously infected with resident MDV strains. This phenomenon is difficult to detect and there is no clear evidence that it is even possible. Four experiments were performed to demonstrate superinfection and evaluate the effect of time between challenges on the effect of superinfection with the use of two pairs of fully virulent MDV strains that could be discriminated by novel technology: 1) JM/102W and rMd5//38CVI, and 2) rMd5 and rMd5//38CVI. Feather follicle epithelium (FFE), spleen, and tumor samples were collected at single or multiple time points from the same bird to determine the frequency and distribution of each virus present following superinfection, with the use of pyrosequencing and immunohistochemistry. Superinfection was observed in 82 of 149 (55%) FFE samples following short-interval challenge (24 hr) compared to only 6 of 121 (5%) samples following long-interval challenge (13 days), indicating a strong influence of challenge interval. In cases where the first inoculated virus was weak or delayed, the second inoculated virus was detected in 42 of 95 (44%) birds. In tumors from dually challenged birds, the second virus was again present much more often following short-interval challenge (68%) compared to long-interval challenge (11%). Virus mixtures in tumors were less common compared to those in FFE samples. Vaccination with turkey herpesvirus had no significant effect on the virus frequency for either virus pair or challenge time interval, suggesting these conclusions may be applicable to vaccinated chickens in the field. These studies demonstrated superinfection for the first time with two fully virulent MDV strains and suggest that short-interval challenge exposure and/or weak initial exposures may be important factors leading to superinfection--a prerequisite for the establishment of a second virus strain in the population. This model system should be useful to elucidate this important phenomenon further. 相似文献
85.
Diagnosis of periodontal disease, a frequent disorder in dogs, rests mainly upon the assessment of changes affecting the gingiva. Loss of gingival stippling, one of the early symptoms of periodontal disease in the human, could also indicate early periodontitis in the dog.The aim of this study was to determine the presence of gingival stippling in dogs, its location on alveolar processes, its association with age and inflammation, and its relation to the microstructure of the gingiva. The study concerns clinical, scanning electron and light microscopic examination of the gingiva of 48 dogs.Stippling, i.e. the granular appearance of the gingiva resembling irregularly distributed crater-like depressions of varying sizes, was present in adult but absent in young and senescent dogs. Stippling was most prominent at the level of the canine and the carnassial teeth. In contrast to the human gingiva, depressions and elevations of the stippled gingiva of the dog were not distributed uniformly. Presence of stippling indicates the presence of well developed mucosal layers and extensive interdigitation of epithelial rete pegs and papillary layer. Interaction of inelastic collagen fibres and a high hyaluronan content within papillary layer resulting in a high turgor of tissue due to the extensive water binding capacity of hyaluronic acid could also play a role in shaping of the gingival surface.The significance of gingival stippling in the diagnosis of periodontal disease in dogs is limited, as stippling occurs in healthy but also slightly inflamed attached gingiva of adult individuals. 相似文献
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Tunica adventitia or tunica externa is the outer layer of the blood vessel wall. It consists of connective tissue with vasa and nervi vasorum and plays a key role in vascular health. The aim of our study was to compare the wall layers beyond tunica media in arteries of different type and location. The following arteries of pig, dog and cat were processed histologically and analysed by light microscopy: aorta ascendens, arcus aortae, aorta thoracica, aorta abdominalis, arteria (a.) femoralis, a. tibialis cranialis, a. carotis communis, a. lingualis, a. basilaris, a. cerebralis media, a. testicularis and aa. jejunales. We found two layers of connective tissue outside the media: (1) a compact layer with many elastic fibres in muscular and few in elastic arteries and (2) an outer layer of loose connective tissue. The compact layer was missing in aorta ascendens, arcus aortae and intracranial vessels. Adventitial stripping removed only the loose connective tissue layer. In spite of the still present compact layer, stripped arteries were very flimsy. We suggest using the term ‘tunica externa’ for the compact connective tissue layer and ‘tunica adventitia’ for the outermost loose connective tissue layer as in other organs. The presence of the tunica externa differs between species, arteries and arterial side, as well as the removability of tunica adventitia and tunica externa by anatomical dissection. 相似文献
88.
The discovery in the early 1980s that soil microorganisms, and in particular the symbiotic bacteria Rhizobium, were highly sensitive to heavy metals initiated a new line of research. This has given us important insights into a range of topics: ecotoxicology, bioavailability of heavy metals, the role of soil biodiversity, and the existence of ‘keystone’ organisms. Concurrently, and particularly in Europe, the research led to new approaches to the protection of soils from pollution that take into account the many effects on soil microorganisms. To date these key findings have largely been ignored in the USA, although our results caused considerable controversy there. In the past decade there have been many advances in the ecotoxicological assessment of metals and their effects on soil organisms but major gaps in knowledge and theory remain with regard to how microorganisms are exposed and respond to metals in soils. In this brief review we emphasise the need for long-term experiments and basic research to forge this understanding and improve environmental protection policies. 相似文献
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90.
Malignant catarrhal fever 总被引:1,自引:0,他引:1