Ectopic ureterocele in a male dog: a case report and review of surgical management

A 16-week-old, male border terrier was presented for urinary incontinence. Intravenous urography demonstrated a right-sided, extravesical ectopic ureterocele. Neoureterocystostomy and ureterocele omentalization were performed. Urinary incontinence persisted after surgery. Retrograde urethrography revealed communication between the ureterocele and urethra. Urinary incontinence resolved following partial ureterocelectomy and reconstruction of the proximal urethra.     

How reliable are amphibian population metrics? A response to Kroll et al.

Kroll et al. [Kroll, A.J., Runge, J.P., MacCracken, J.G., 2009. Unreliable amphibian population metrics may obfuscate more than they reveal. Biological Conservation] criticized our recent advocacy for combining readily attainable metrics of population status to gain insight about relationships between terrestrial plethodontid salamanders and forest succession [Welsh, Jr., H.H., Pope, K.L., Wheeler, C.A., 2008. Using multiple metrics to assess the effects of forest succession on population status: a comparative study of two terrestrial salamanders in the US Pacific Northwest. Biological Conservation 141, 1149–1160]. They argue that each of our metrics has the potential to be biased or flawed and, therefore, any inferences so derived are likely to be uncertain and misleading. One of our main goals was to highlight the value of combining multiple quantitative approaches with logic, knowledge of species’ biology and parsimony when interpreting findings, as a means to counter uncertainty that might occur with any single metric. We applied a sampling design that minimizes the chance of bias in detections and counts, included multiple statistical methods to test relationships, and incorporated past research and species’ biology when interpreting findings. We disagree with Kroll et al. [Kroll, A.J., Runge, J.P., MacCracken, J.G., 2009. Unreliable amphibian population metrics may obfuscate more than they reveal. Biological Conservation] that the potential biases associated with the individual metrics mean that the inferences from the study are too uncertain to be useful by managers. We examined metrics that are more informative than simple site occupancy, including relative abundance, life stage distributions, and body condition, to inform our knowledge of population status. Combining metrics allows us to use readily attainable data to yield deeper insights into population structure and related spatial aspects. We agree on the value of having the most detailed and accurate data possible, but do not believe this standard should limit one to conducting only intensive experimental studies to provide detailed information on vital rates of terrestrial salamanders. The controlled experiment approach is extremely difficult and would be considerably less feasible than using population metrics to assess the status of plethodontid salamanders on forest landscapes at scales relevant to land management in the Pacific Northwest.     

Immunopathologic investigations with an attenuated chicken anemia virus in day-old chickens

The immunopathologic effects induced by two attenuated chicken anemia virus (CAV) isolates, known as cloned isolate 34 (CI 34) and cloned revertant isolate 18 (CRI 18), that were derived from highly passaged pools of Cux-1 CAV isolate, were compared with those induced by a pathogenic, molecularly cloned, low-passage Cux-1 isolate (CI Cux). This comparison involved the intramuscular inoculation of 1-day-old specific-pathogen-free chicks with each of the viruses and investigation of birds at selected days postinoculation for gross pathology and depletions in the thymic T-cell populations as determined by flow cytometry. Whereas infection with the pathogenic CI Cux produced severe anemia and pronounced bone marrow and thymus lesions, infections with the attenuated CRI 18 and CI 34 isolates produced no anemia, no or mild lesions, respectively, and moderate T-cell depletion. The results suggest that, with CAV, reduced pathogenicity for 1-day-old chicks correlates with reduced depletion of T-cell populations in the thymus and with reduced severity of lesions in the thymus and bone marrow.     

Influence of dietary energy intake on prepubertal development of Brahman bulls

Twelve Brahman bulls (paired by sire, weight and age) were assigned randomly and limit fed to gain either .10 to .25 (moderate gain; MG) or .75 to 1.0 (high gain: HG) kg.hd-1.d-1 to examine the effect of dietary energy on onset of puberty. Hip height (HH), scrotal circumference (SC) and serum samples (20 min for 6 h) were obtained at four times (AGE): 0, 56 and 112 d on feed and after appearance of first motile spermatozoa (FS) in the ejaculate of HG bull of the pair. At FS both bulls of a pair were slaughtered, reproductive tissues were collected and in vitro GnRH release from the median eminence (ME) was measured. Increases in BW, HH and SC were greater (P less than .05) in HG bulls. Basal ME GnRH secretion was greater (P less than .05) in HG bulls. Serum LH concentrations were unchanged by energy level (P greater than .10) but increased (P less than .01) with increasing AGE. AGE and energy level increased (P less than .01) basal, mean and total serum testosterone (T) and these two factors acted synergistically (P less than .01). Height and amplitude of T pulses were increased by energy level (P less than .003) and AGE (P less than .002). Testicular T (P less than .08) and development (P less than .05) were increased in HG bulls. Growth hormone peak height and amplitude concentrations following feeding increased with AGE (P less than .06) but were not altered (P greater than .10) by energy level. Serum triglycerides (P less than .03) and BUN (P less than .003) increased with increasing AGE (P greater than .01). These data indicate that dietary energy level influences onset of puberty most directly at the testicular level.     

Epizootic of Yersinia pseudotuberculosis in a wildlife park.

An epizootic attributable to Yersinia pseudotuberculosis infection was confirmed in captive ruminants in a wildlife park by microbiologic and histologic findings. An epornitic of Y pseudotuberculosis infection was identified at the same period in a vicinity near the ruminant deaths. Yersinia pseudotuberculosis can infect human beings and cause acute enteritis and mesenteric lymphadenitis. People in contact with infected animals should use extreme caution and use good sanitary precautions to preclude transmission of this agent.     

Pain mechanisms and their implication for the management of pain in farm and companion animals

Over the last two decades there has been a dramatic increase in the literature relating to the mechanisms and management of pain in domestic animals. Understanding the mechanisms of pain is crucial for its effective management. This review highlights the current understanding of the neurophysiology of nociception and the plastic changes involved in chronic pain states. Additionally, we describe a range of novel molecules and pathways that offer opportunities for the development of mechanism-based analgesic therapies. Pain management in animals is limited by pain assessment which remains highly subjective, with clinicians relying on indirect measures of pain, using rating scales and (less frequently) quantifiable physiological and behavioural parameters. The need for a systematic approach which would assess different pain components is well justified. Species-specific issues on pain assessment and management in mammalian companion and farm animals are addressed in the later part of this review.