Resident forum abstractsEVALUATION OF THROMBOELASTOGRAPHY (TEG) IN NORMAL CATS

Objective: To establish normal parameters of thromboelastography (TEG) in healthy adult cats. Background: Thromboelastography (TEG) is an in vitro test of coagulation that has been shown to be useful in humans, dogs and select species to identify and quantify alterations of hemostasis (e.g., hypercoagulable and hypocoagulable states). It has also been demonstrated to be useful in monitoring effects of anticoagulant therapies. This test has not been evaluated in cats. Methods: Blood was collected from 25 clinically normal cats by venipuncture using a 21 gauge×3 1/2 inch butterfly catheter and syringe for medial saphenous or jugular venipuncture. A single 1.8 mL sample in 3.8% Sodium Citrate (9:1) was collected from each cat. Recalcified whole blood was analyzed 30 minutes following collection with the TEG® 5000 analyzer (Haemoscope, Niles, IL). Analysis temperature was 37.6°C. TEG parameters recorded included: R‐value (represents initial fibrin formation), K (time from R to standard fixed measure of clot firmness which represents contributions of platelets and fibrinogen), maximum amplitude (MA; represents absolute clot strength), and alpha angle (α; the slope of TEG tracing which represents rate of clot formation). The coagulation index (CI) was derived from the formula generated for humans to provide an overall assessment of whether the sample was hyper‐ or hypocoagulable. Results: Values for the 25 normal cat samples are reported as mean ±2 standard deviations. R=2.97; 1.23–4.72; K=1.54, 0.38–2.71; α=70.70, 57.76–83.65; MA=58.50, 45.26–71.74 and CI=2.27, 0.07–4.46. Compared to historical information obtained on normal dogs, cats have significantly shorter R and K and larger α, MA and CI. Conclusions: TEG does have reproducible performance when used to evaluate coagulation status in normal cats. Compared to dogs, normal cats favor a hypercoagulable state. Species‐specific normal values are necessary for interpretation of TEG results. This test bears potential value for use in future experimental and clinical work to investigate hemostasis in cats receiving anticoagulant therapies or in cats suffering from diseases such as cardiomyopathy which are thought to be associated with altered coagulation status.     

Changing market culture in the Pacific: Assembling a conceptual framework from diverse knowledge and experiences

Addressing the multiple dimensions of gender inequality requires commitments by policy‐makers, practitioners and scholars to transformative practices. One challenge is to assemble a coherent conceptual framework from diverse knowledges and experiences. In this paper, we present a framework that emerged from our involvement in changing market culture in the Pacific, which we name a radical empowerment of women approach. We draw on detailed narratives from women market vendors and women‐led new initiatives in marketplaces to explain this approach. We argue that the primary focus of recently developed projects for marketplaces in the Pacific is technical and infrastructural, which is insufficient for addressing gendered political and economic causes of poor market management and oppressive conditions for women vendors. By exploring the complex array of motives and effects of the desire to transform or improve marketplaces in the Pacific, we caution against simplistic technical or infrastructural solutions. This paper also introduces the practice of working as a cooperative, hybrid research collaboration. The knowledges and analyses that we bring to this issue demonstrate that substantive analysis generated from diverse and shifting ‘locations’ and roles, but underpinned by a shared vision of, and commitment to, gender justice, can provide distinctive policy and research insights.     

Filling hollowed out spaces with localised meanings,practices and hope: Progressive neoliberal spaces in Te Rarawa

The contracting out to private providers of services previously delivered within the state has been framed critically as ‘hollowing out’ and read for its erosion of social democracy, social justice and welfare, as well as its inefficiencies in practice. It is commonly dismissed as neoliberalism. In this paper, we highlight the gains made through this new contractualism by Te Oranga, the Family, Health and Education division of Te Runanga o Te Rarawa located in the Far North of New Zealand. Our aim is not to narrate the exceptional, but to point to the inherent resistances to totalising projects residing in agency and place. Placed at the service of a deep sense of community being and community good rather than self‐interest, delivery contracts have enabled Te Oranga to pursue an alternative form of local development and craft a set of progressive spaces. Although highly contingent upon powerful Maori political projects, we argue that the case suggests that gains may be sought in other settings, albeit partial, temporary, and politically contingent. We thus offer a more nuanced account of neoliberalism by highlighting its agency, fractures, politics, and contradictions, and by demonstrating that actualised neoliberalisms are co‐constituted with other political projects.     

The relationship of subsequent racing performance to foreleg flight patterns during racing speed workouts of unraced 2-year-old Thoroughbred racehorses at auctions

Workouts of 980 unraced 2-year-old Thoroughbred racehorses at major U.S. auctions were videotaped using digital high-speed video equipment (ie, slow motion) and studied for signs of extraneous foreleg motion.^a Extraneous foreleg motion included, but was not limited to: 1) hyper rotation of the cannon bone on an axis parallel to the plane of the running surface (ie, moving in sagittal plane; hoof hitting an elbow in extreme cases) and perpendicular to the direction of the racetrack longitudinally; and 2) foreleg flight patterns not symmetrical and/or not parallel to the vector of the forward momentum of the horse's center of gravity (eg, winging, paddling, and/or wobbling at joints). Experienced Thorough bred racehorse industry videographers and gait analysis researchers were trained and used as film reviewers who rated foreleg motion on a scale of 1 to 5, with 1 indicating little or no extraneous motion, 3.5 indicating average extraneous motion (relative to the other unraced 2-year-olds at these auctions and to more than 20,000 similar horses at similar auctions over the past 10 years), and 5 indicating extreme extraneous motion (ie, at least 1 standard deviation or more from the mean). Because these were subjective ratings, only the more extreme rankings were used for comparison purposes in this study—that is, a minority (15.3%) of the overall study population.

A group of 73 horses with “good” foreleg motion had ratings from 1 to 3. A group of 77 horses with “bad” foreleg motion had ratings from 4 to 5. The subsequent North American racing performance of horses with good and bad foreleg motion was compared. Both groups had similar average velocity and similar distribution patterns of the velocities of the workouts, so the differences between the groups that are discussed in this study were not caused by different overall workout velocities.

Extraneous foreleg motion was shown to be related to subsequent racing earnings and the level of racing competition achieved. Horses with good foreleg motion (as defined herein) earned more and had greater stakes-level success than horses with bad foreleg motion. For example, the median earnings per start of horses with good foreleg motion was 83% higher than those of horses with bad foreleg motion, and horses with good foreleg motion were 58% more likely to win a top race (ie, one designated as a “graded” stakes) than horses with bad foreleg motion. However, the “good movers” raced less overall than the “bad movers.”

A secondary finding of this study is that although there is a widely held industry belief that horses with high action or bad foreleg motion are more suited to turf racing, horses with good foreleg motion were more likely than horses with bad foreleg motion to race at least once on turf, and, among horses to race on turf, horses with good foreleg motion were more likely than horses with bad foreleg motion to win and to finish “in the money” (ie, at least third).     

The genetic legacy of Paleolithic Homo sapiens sapiens in extant Europeans: a Y chromosome perspective

A genetic perspective of human history in Europe was derived from 22 binary markers of the nonrecombining Y chromosome (NRY). Ten lineages account for >95% of the 1007 European Y chromosomes studied. Geographic distribution and age estimates of alleles are compatible with two Paleolithic and one Neolithic migratory episode that have contributed to the modern European gene pool. A significant correlation between the NRY haplotype data and principal components based on 95 protein markers was observed, indicating the effectiveness of NRY binary polymorphisms in the characterization of human population composition and history.     

Ultraviolet Spectra of Stars: The ultraviolet spectra of stars are discussed from both theoretical and observational viewpoints

According to theories of model stellar atmospheres only stars of spectral types from O to about B3 may be expected to be bright in the ultraviolet-wavelength region. Observations of the strong resonance lines between 911.6 and 1900 A will yield new information permitting construction of better models for the outermost layers of OB stars. However, an adequate theory of line-formation, including non-l.t.e. effects, should be used if an accurate physical representation is to result. Already it has been demonstrated beyond doubt that O and B0 supergiants are surrounded by expanding atmospheres.