Sr lattice clock at 1 x 10(-16) fractional uncertainty by remote optical evaluation with a Ca clock

Optical atomic clocks promise timekeeping at the highest precision and accuracy, owing to their high operating frequencies. Rigorous evaluations of these clocks require direct comparisons between them. We have realized a high-performance remote comparison of optical clocks over kilometer-scale urban distances, a key step for development, dissemination, and application of these optical standards. Through this remote comparison and a proper design of lattice-confined neutral atoms for clock operation, we evaluate the uncertainty of a strontium (Sr) optical lattice clock at the 1 x 10(-16) fractional level, surpassing the current best evaluations of cesium (Cs) primary standards. We also report on the observation of density-dependent effects in the spin-polarized fermionic sample and discuss the current limiting effect of blackbody radiation-induced frequency shifts.     

SOS response induction by beta-lactams and bacterial defense against antibiotic lethality

The SOS response aids bacterial propagation by inhibiting cell division during repair of DNA damage. We report that inactivation of the ftsI gene product, penicillin binding protein 3, by either beta-lactam antibiotics or genetic mutation induces SOS in Escherichia coli through the DpiBA two-component signal transduction system. This event, which requires the SOS-promoting recA and lexA genes as well as dpiA, transiently halts bacterial cell division, enabling survival to otherwise lethal antibiotic exposure. Our findings reveal defective cell wall synthesis as an unexpected initiator of the bacterial SOS response, indicate that beta-lactam antibiotics are extracellular stimuli of this response, and demonstrate a novel mechanism for mitigation of antimicrobial lethality.     

Big and mighty: preverbal infants mentally represent social dominance

Human infants face the formidable challenge of learning the structure of their social environment. Previous research indicates that infants have early-developing representations of intentional agents, and of cooperative social interactions, that help meet that challenge. Here we report five studies with 144 infant participants showing that 10- to 13-month-old, but not 8-month-old, infants recognize when two novel agents have conflicting goals, and that they use the agents' relative size to predict the outcome of the very first dominance contests between them. These results suggest that preverbal infants mentally represent social dominance and use a cue that covaries with it phylogenetically, and marks it metaphorically across human cultures and languages, to predict which of two agents is likely to prevail in a conflict of goals.     

Yields of wheat and soil carbon and nitrogen contents following long-term incorporation of barley straw and ryegrass catch crops

Abstract. Three successive crops of winter wheat were grown on a sandy loam to test the residual effect of long‐term annual incorporation of spring barley straw at rates of 0, 4, 8 and 12 t ha^?1, and ryegrass catch crops with or without additions of pig slurry. Soil receiving 4, 8 and 12 t ha^?1 of straw annually for 18 years contained 12, 21 and 30% more carbon (C), respectively, than soil with straw removal, and soil C and nitrogen (N) contents increased linearly with straw rate. The soil retained 14% of the straw C and 37% of the straw N. Ryegrass catch‐cropping for 10 years also increased soil C and N concentrations, whereas the effect of pig slurry was insignificant. Grain yield in the first wheat crop showed an average dry matter (DM) increase of 0.7 t ha^?1 after treatment with 8 and 12 t straw ha^?1. In the two subsequent wheat crops, grain yield increased by 0.2–0.3 t DM ha^?1 after 8 and 12 t straw ha^?1. No grain yield increases were found after 4 t straw ha^?1 in any of the three years. Previous ryegrass catch crops increased yields of wheat grain, but effects in the third wheat crop were significant only where ryegrass had been combined with pig slurry. Straw incorporation increased the N offtake in the first wheat crop. In the second crop, only 8 and 12 t straw ha^?1 improved wheat N offtake, while the N offtake in the third wheat crop was unaffected. Ryegrass catch crops increased N offtake in the first and second wheat crop. Again, a positive effect in the third crop was seen only when ryegrass was combined with slurry. Long‐term, annual incorporation of straw and ryegrass catch crops provided a clear and relatively persistent increase in soil organic matter levels, whereas the positive effects on the yield of subsequent wheat crops were modest and transient.     

Computers in aquaculture

Computer application to aquaculture operations is a timely and new transition in the management of the business. Decision making using real time data increases efficiency and production economics and aids in market planning. A general overview of computer approaches is discussed and a data management design approach is described which focuses on priority tasks. This method enhances the accuracy of animal inventory data and growth tracking where production costs are reduced through improved feed administration. The examples are only a small portion of the total program and reflect an approach used for a prawn farm. The modules in the programs are individually designed for the type of operation and species.     

The effect of grazing on cow mortality in Danish dairy herds

The effect of summer grazing in large Danish dairy herds and certain management characteristics of grazing were studied for their impact on dairy cow mortality. Mortality data (from the Danish Cattle Database) from 391 Danish dairy herds (>100 cows) were combined with information from a questionnaire survey of grazing procedures on these herds in 2008. In all, 131 of the herds were identified as summer grazing and 260 as zero-grazing herds. The mortality was affected by an interaction of summer grazing and milking system. The risk of a cow dying was reduced to 46% in a grazing compared to a zero-grazing herd having automatic milking system. In traditional milking system, mortality was reduced to 75% in grazing compared to zero-grazing herds. Within the grazing herds, the risk of mortality decreased with increasing number of hours on pasture during the season. Free access between barn and pasture was associated with increased cow mortality.     

Mycobacterium kansashi infection in a bontebok (Damaliscus pygaragus dorcas) herd: diagnostic challenges in differentiating from the Mycobacterium tuberculosis complex

Two adult female bontebok (Damaliscus pygarus dorcas) were euthanized because of signs of pneumonia and weakness (case 1), and a nonresponsive lameness with draining fistula (case 2). Necropsy findings were similar in both cases and consisted of disseminated granulomatous lesions in the liver, kidneys, spleen, lungs, pleural surfaces, and multiple lymph nodes. Mycobacterium kansasii was isolated from both cases after multiple attempts on a variety of samples by two laboratories. The remaining four animals in the herd were tested for antibody responses using the Chembio ElephantTB STAT-PAK, DPP VetTB kits, and multi-antigen print immunoassay (MAPIA), for immune reaction using the intradermal tuberculin test, and by tracheal wash cultures, and thoracic radiographs. Banked serum samples collected in 2005 and obtained from the original institution, revealed 1/9 (11.11%) seropositive animals using the three immunoassays. Retesting the current herd in 2008 showed 2/6 (33.33%) seropositive animals by the three tests, with MAPIA demonstrating antibody reactivity to MPB83 and MPB70 proteins. Inconsistent intradermal tuberculin test results, cross-reactivity in serologic assays designed for tuberculosis detection, difficulty in obtaining definitive identification by culture, and inability to identify a source of infection created challenges in distinguishing the atypical mycobacteriosis due to M. kansasii from the initially suspected tuberculous infection in this herd. Owing to regulatory considerations, differences in host-to-host transmission, and source of infection between Mycobacterium tuberculosis complex and nontuberculous mycobacteria, correct diagnosis is crucial for management of these diseases in wildlife species.     

Cutaneous asthenia in the dog. A report of two cases

Two cases of cutaneous asthenia in Danish dogs are described. Case 1 was a Weimeraner; case 2 a Golden Retriever. In both instances the dogs had acquired numerous lesions of the skin within the first half year of their lives. The wounds exhibited good healing but led to broad, thin and pliable scars. Both dogs had in several instances received attention to gaping wounds, characterized by little tendency of bleeding. The clinical examination reveiled that the skin was hyperextensible and possessed pendulous folds, particularly behind the elbows. The degree of hyperextensibility was evaluated by means of a skin extensibility index. Furthermore, it was possible to manipulate the digital cushion in an unphysiological manner. One of the dogs were euthanised, and in case 2 the clinical diagnosis was confirmed by histopathological examination. No conclusion could be drawn regarding the mode of inheritance in the two cases, but existing literature strongly suggests the existence of a genetic disposition and thus, elimination of the disease related gene from any breeding program is of great importance.     

Contact dermatitis in the dog. A review and a clinical study

Allergic, irritative and photosensitive contact dermatitides make up a group of dermatoses which have traditionally been associated with some difficulties in diagnostication. The reason for this is the problems encountered in setting up, keeping in place, and reading the patch test which is the diagnostic tool relevant to veterinary practice. In the present study, a review of the disease complex is given, and a clinical study, dealing with allergic contact dermatitis, performed with materials and methods available to the small animal practitioner, is discussed with regards to symptomatology, diagnostic work, and therapy. With appropriate management, consisting in an attempt to eliminate the offending item(s), and glucocorticoid therapy adjusted to the clinical response, the disease carries a good prognosis.