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Rivière D Pingret JL Etievant M Jechoux A Lanore D Raymond-Letron I Boucraut-Baralon C 《Journal of Feline Medicine and Surgery》2011,13(2):125-128
An 18-month-old neutered male domestic shorthair cat, domiciled in the southwest of France, was first presented having suffered for a few days from dysorexia and vomiting. Abdominal palpation revealed lymph node enlargement. Cytological examinations of a fine needle aspirate demonstrated granulomatous inflammation with many non-staining elements consistent with mycobacteria. Diagnosis was confirmed by culture and polymerase chain reaction and Mycobacterium avium subspecies was isolated. Treatment was initiated with marbofloxacin, rifampicin and cefoxitin. There was a rapid clinical improvement. The cat suddenly died 2 months later. The main hypothesis is the administration of an inappropriate combination therapy that leads to the development of mycobacterial resistance. A volvulus and acute peritonitis secondary to the significant enlargement of a mesenteric lymph node were present at necropsy. Histopathological analysis of mesenteric lymph node, liver and spleen revealed multicentric granulomatous and severely necrotic lesions with numerous Ziehl-Neelsen positive intracytoplasmic elements. 相似文献
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Aerosol effect on cloud droplet size monitored from satellite 总被引:5,自引:0,他引:5
Aerosol concentration and cloud droplet radii derived from space-borne measurements are used to explore the effect of aerosols on cloud microphysics. Cloud droplet size is found to be largest (14 micrometers) over remote tropical oceans and smallest (6 micrometers) over highly polluted continental areas. Small droplets are also present in clouds downwind of continents. By using estimates of droplet radii coupled with aerosol load, a statistical mean relationship is derived. The cloud droplet size appears to be better correlated with an aerosol index that is representative of the aerosol column number under some assumptions than with the aerosol optical thickness. This study reveals that the effect of aerosols on cloud microphysics is significant and occurs on a global scale. 相似文献
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Lebreton A Lakisic G Job V Fritsch L Tham TN Camejo A Matteï PJ Regnault B Nahori MA Cabanes D Gautreau A Ait-Si-Ali S Dessen A Cossart P Bierne H 《Science (New York, N.Y.)》2011,331(6022):1319-1321
Intracellular pathogens such as Listeria monocytogenes subvert cellular functions through the interaction of bacterial effectors with host components. Here we found that a secreted listerial virulence factor, LntA, could target the chromatin repressor BAHD1 in the host cell nucleus to activate interferon (IFN)-stimulated genes (ISGs). IFN-λ expression was induced in response to infection of epithelial cells with bacteria lacking LntA; however, the BAHD1-chromatin associated complex repressed downstream ISGs. In contrast, in cells infected with lntA-expressing bacteria, LntA prevented BAHD1 recruitment to ISGs and stimulated their expression. Murine listeriosis decreased in BAHD1(+/-) mice or when lntA was constitutively expressed. Thus, the LntA-BAHD1 interplay may modulate IFN-λ-mediated immune response to control bacterial colonization of the host. 相似文献
228.
Luc Baudouin Claire Baril André Clément-Demange Thierry Leroy Didier Paulin 《Euphytica》1997,96(1):101-114
The recurrent selection schemes recommended by CIRAD for 6 tropical tree crops are presented and compared. Breeding programmes
are carried out under cooperation between CIRAD and its partners in regions where the crops are grown. The crops are cacao,
coffee, rubber tree, oil palm, coconut and eucalyptus. After a short look at the background, the reasons behind the options
chosen are given and the main characteristics of the schemes are described and illustrated. The state of progress and some
major results are discussed. Over and above the differences linked to plant biology, the genetic diversity available and the
type of varietal output, common characteristics are emphasized. The time taken for each generation means simplifying the intercrossing
phases between successive breeding cycles, and thus, the parents tested are heterozygous: whenever possible, a clonal varietal
output is an additional source of progress. The use of biotechnologies to study diversity is a valuable asset, and their application
for early selection (QTL) is also promising. The preponderance of combining ability coexists with marked heterosis, which
poses the problem of the latter's origin. As a result, all of the schemes described, but one, are reciprocal recurrent selection
schemes.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
229.
Stainier DY 《Science (New York, N.Y.)》2005,307(5717):1902-1904
The function of an organ is dependent on its cellular constituents as well as on their assembly into a cohesive unit. The developing gut faces unique challenges as one of the longest and largest organs in the body and also because it is constantly interfacing with external factors through the diet. Its location deep within the body has until recently hampered investigation into its formation. The patterning of the gut along its longitudinal, dorsoventral, left-right, and radial axes is one of the fascinating issues that pertain to the development, function, and homeostasis of this understudied organ. 相似文献