Subsidence in the northeastern nile delta: rapid rates, possible causes, and consequences

Holocene fluvial and marine deposits have accumulated in a graben-like structure on the northeastern margin of the Nile delta. This part of the delta, which includes Lake Manzala, Port Said, and the northern Suez Canal, has subsided rapidly at rates of up to 0.5 centimeter per year since about 7500 years ago. This subsidence has diverted at last four major distributaries of the Nile River into this region. The combined effects of continued subsidence and sea level rise may flood a large part of the northern delta plain by as much as 1 meter by the year 2100. The impact of continued subsidence, now occurring when sediment input along the coast has been sharply reduced because of the Aswan High Dam, is likely to be substantial, particularly in the Port Said area and as far inland as south of Lake Manzala.     

Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA

Helicobacter pylori translocates the protein CagA into gastric epithelial cells and has been linked to peptic ulcer disease and gastric carcinoma. We show that injected CagA associates with the epithelial tight-junction scaffolding protein ZO-1 and the transmembrane protein junctional adhesion molecule, causing an ectopic assembly of tight-junction components at sites of bacterial attachment, and altering the composition and function of the apical-junctional complex. Long-term CagA delivery to polarized epithelia caused a disruption of the epithelial barrier function and dysplastic alterations in epithelial cell morphology. CagA appears to target H. pylori to host cell intercellular junctions and to disrupt junction-mediated functions.     

Hemoglobin kinetics and the effect of organic phosphates

A kinetic model based on allosteric mechanisms of cooperativity fits the experimentally observed phosphate dependence of hemoglobin reactions. Subunit inequivalence is found to be important in analyzing hemoglobin kinetics. The observed increase in the rate of deoxygenation in the presence of organic phosphates is primarily related to the increased rate of dissociation of the second oxygen molecule.