渠道运行神经网络控制

针对渠道运行的不确定性和非线性,在渠道自动控制系统的观测器回路上并联一个BP神经网络,通过实测水位的学习,修正控制系统数学模型的不准确性;在控制器增益回路上并联一个BP神经网络,补偿控制增益的不精确。与传统的线性二次调节(LQR)最优控制相比,渠道运行控制过渡过程更为平稳,达到稳定的时间缩短,闸门运行的振动和超调大为改善。     

鹅对菜籽粕代谢能和营养物质利用率的评定

【目的】利用套算法评定不同来源菜籽粕的鹅代谢能及营养物质利用率。【方法】选取健康、体重接近的200日龄成年公鹅30只,随机分为5组(Ⅰ、Ⅱ、Ⅲ、Ⅳ、Ⅴ组),每组6个重复,每个重复1只鹅。4种菜籽粕分别由加拿大进口油菜籽及江苏省苏州市、宿迁市、盐城市本地生产的油菜籽榨油而成。采用强饲法进行代谢试验,强饲量80 g,试验Ⅰ、Ⅱ、Ⅲ、Ⅳ组分别以4种菜籽粕替代30%基础饲粮,试验Ⅴ组强饲基础饲料,并收集内源粪便,做内源校正。【结果】(1)4种菜籽粕中的总能(GE)、干物质(DM)、粗蛋白质(CP)、粗脂肪(EE)、粗灰分(Ash)、酸性洗涤纤维(ADF)、中性洗涤纤维(NDF)、钙(Ca)、总磷(TP)含量的平均值分别是17.48 MJ/kg、88.95%、42.22%、2.47%、7.93%、22.42%、37.81%、0.83%和1.09%。(2)鹅对4种菜籽粕的表观代谢能(AME)、真代谢能(TME)平均值分别为12.27和13.05 MJ/kg,且AME、TME存在显著的组间差异(P<0.05);鹅对4种菜籽粕CP真利用率平均值为44.84%,对DM、EE、Ash、ADF、NDF...     

Fucose-Rich Sulfated Polysaccharides from Two Vietnamese Sea Cucumbers Bohadschia argus and Holothuria (Theelothuria) spinifera: Structures and Anticoagulant Activity

Fucosylated chondroitin sulfates (FCSs) FCS-BA and FCS-HS, as well as fucan sulfates (FSs) FS-BA-AT and FS-HS-AT were isolated from the sea cucumbers Bohadschia argus and Holothuria (Theelothuria) spinifera, respectively. Purification of the polysaccharides was carried out by anion-exchange chromatography on DEAE-Sephacel column. Structural characterization of polysaccharides was performed in terms of monosaccharide and sulfate content, as well as using a series of non-destructive NMR spectroscopic methods. Both FCSs were shown to contain a chondroitin core [→3)-β-d-GalNAc-(1→4)-β-d-GlcA-(1→]_n bearing sulfated fucosyl branches at O-3 of every GlcA residue in the chain. These fucosyl residues were different in pattern of sulfation: FCS-BA contained Fuc2S4S, Fuc3S4S and Fuc4S at a ratio of 1:8:2, while FCS-HS contained these residues at a ratio of 2:2:1. Polysaccharides differed also in content of GalNAc4S6S and GalNAc4S units, the ratios being 14:1 for FCS-BA and 4:1 for FCS-HS. Both FCSs demonstrated significant anticoagulant activity in clotting time assay and potentiated inhibition of thrombin, but not of factor Xa. FS-BA-AT was shown to be a regular linear polymer of 4-linked α-L-fucopyranose 3-sulfate, the structure being confirmed by NMR spectra of desulfated polysaccharide. In spite of considerable sulfate content, FS-BA-AT was practically devoid of anticoagulant activity. FS-HS-AT cannot be purified completely from contamination of some FCS. Its structure was tentatively represented as a mixture of chains identical with FS-BA-AT and other chains built up of randomly sulfated alternating 4- and 3-linked α-L-fucopyranose residues.     

Progress in Isoindolone Alkaloid Derivatives from Marine Microorganism: Pharmacology,Preparation, and Mechanism

Compound 1 (SMTP-7, also FGFC1), an isoindolone alkaloid from marine fungi Starchbotrys longispora FG216 and fungi Stachybotrys microspora IFO 30018, possessed diverse bioactivities such as thrombolysis, anti-inflammatory and anti-oxidative properties, and so on. It may be widely used for the treatment of various diseases, including cerebral infarction, stroke, ischemia/reperfusion damage, acute kidney injury, etc. Especially in cerebral infarction, compound 1 could reduce hemorrhagic transformation along with thrombolytic therapy, as the traditional therapies are accompanied with bleeding risks. In the latest studies, compound 1 selectively inhibited the growth of NSCLC cells with EGFR mutation, thus demonstrating its excellent anti-cancer activity. Herein, we summarized pharmacological activities, preparation of staplabin congeners—especially compound 1—and the mechanism of compound 1, with potential therapeutic applications.     

基于偏离-份额分析法的河池市农业产业结构分析

为促进河池市农业产业结构升级和提高农业产业竞争力,运用偏离-份额分析法对河池市2009年和2018年农业产业结构进行定量分析.结果 发现,河池市农业产业结构中,种植业内部结构不合理,缺乏竞争力;林业结构较好,有一定竞争力;牧业、渔业具有一定竞争力,但产业结构不合理;农林牧渔服务业内部结构有一定优势,但整体竞争力水平较低...     

不同生物刺激剂对鲜食玉米产量和品质的影响

为研究生物刺激剂对玉米的增产提质效果,试验探讨不同生物刺激剂对玉米的产量和品质方面的影响,为鲜食玉米的优质高产栽培提供技术支撑。以鲜食玉米‘钱江糯3号’为试验品种,以3种生物刺激剂（阿美滋、美基、保康灵1号）为供试药剂,设置6个处理（阿美滋1000倍液、阿美滋1500倍液、阿美滋2000倍液、美基3000倍液、保康灵1号300倍液、清水对照）,研究大田常规施肥水平下药剂对‘钱江糯3号’的经济性状、产量及品质的影响。在阿美滋1500倍液喷施下,玉米的行粒数、单穗鲜重和单穗净重、产量均最高,蛋白质含量、粗纤维含量、还原糖含量、淀粉含量均居第3位;在保康灵1号300倍液喷施下,玉米的穗粗最高,单穗鲜重、单穗净重、产量均居第2位,蛋白质含量最高,脂肪含量最低,还原糖含量居第2位。阿美滋1500倍液在增加玉米产量上是最佳选择,保康灵1号300倍液则对提升玉米品质最有效果。建议生产上将阿美滋1500倍液与保康灵1号300倍液配合施用,这对鲜食玉米的增产提质效果最好。     

白花蛇舌草超微粉对小鼠免疫功能的影响

The assay was aimed to study the effect of Hedyotis diffusa Willd superfines powder on immune function. Three groups of mice were gavaged with the drugs at doses of 1.75,1.25 and 0.75 g/kg once a day for 7 consecutive days, repectively. The mice of control group were administered with the same volume of saline.At the last time, mice were injected into the muscle with Newcastle disease vaccine,and get peripheral blood on days 7, 14 and 21 after the medicine administration. The enhancement of innate immune responses were evaluated by using CCK-8 method, hemagglutination inhibition test, macrophage phagocytic function test and organ coefficient method. The levels of lymphocytes proliferative capacity, serum antibody, peritoneal macrophage phagocytosis and the indexes of immune organs in mice were extremely significantly enhanced (P＜0.01). Hedyotis diffusa dWilld superfines powder could extremely significantly regulate the immunity function of mice (P＜0.01).     

参麦与黄芪注射液联用治疗卡氏肺孢子虫肺炎

为研究参麦与黄芪注射液联用对大鼠卡氏肺孢子虫肺炎(PCP)的治疗效果,以地塞米松连续肌肉注射Wistar大鼠6周,建立PCP大鼠模型,用参麦与黄芪注射液皮下注射治疗患病大鼠,同时设复方磺胺甲恶唑(SMZ-TMP)治疗对照组和PCP模型阳性对照组。通过各组大鼠基本情况变化、肺组织印片检查包囊、肺组织病理切片染色观察组织变化,探讨其治疗效果。结果发现,参麦与黄芪注射液联用治疗后,大鼠饮食、饮水增加,活跃程度恢复,体重不同程度增加,肺印片Pc包囊数量比治疗前明显减少,肺组织炎症反应减轻,高剂量组治疗效果接近复方磺胺甲恶唑组。研究结果表明,参麦与黄芪注射液对肺孢子虫有明显的治疗作用。     

Molecular Cloning,Sequence Analysis and Tissues Expression Profile of Part of Mink Toll-like Receptors (TLRs) Genes

The present study was aimed to explore the potential role of Toll-like receptors (TLRs) on the mink immunity, and accumulate alternative genetic material for the mink breeding for disease-resistant.Four pairs of primers were designed according to ferret TLR sequences in GenBank to obtain the sequences of TLR genes (TLR4, TLR6, TLR7 and TLR8) of mink and then performed bioinformatics analysis of these sequences.In addition, the expression of TLR4 and TLR7 genes in various tissues in young and adult minks were analyzed by RT-PCR. Sequence homology analysis showed that mink had higher homology with carnivora (ferrets, polar bear, panda, walrus, seals, dog, tiger and cat) which had the nearest perimeter in the phylogenetic tree.Tissue expression analysis showed that TLR4 and TLR7 were widely and differently expressed in variety tissues of mink.Interestingly, the expression of TLR4 and TLR7 in young mink were much higher than that in adult mink.     

Revelation of Rural System of Medical Services in BRICS to China

In recent years, the great achievements of basic medical and healthcare services of BRICS have gained great attention and acknowledgement from the whole world. In their medical system reform, India, Br...