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排序方式: 共有400条查询结果,搜索用时 171 毫秒
391.
Human recombinant granulocyte-macrophage colony-stimulating factor: a multilineage hematopoietin 总被引:33,自引:0,他引:33
C A Sieff S G Emerson R E Donahue D G Nathan E A Wang G G Wong S C Clark 《Science (New York, N.Y.)》1985,230(4730):1171-1173
Human recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF) was tested for its ability to induce colony formation in human bone marrow that had been enriched for progenitor cells. In addition to its expected granulocyte-monocyte colony-stimulating activity, the recombinant GM-CSF had burst-promoting activity for erythroid burst-forming units and also stimulated colonies derived from multipotent (mixed) progenitors. In contrast, recombinant erythroid-potentiating activity did not stimulate erythroid progenitors. The experiments prove that human GM-CSF has multilineage colony-stimulating activity. 相似文献
392.
Mukhtar MS Carvunis AR Dreze M Epple P Steinbrenner J Moore J Tasan M Galli M Hao T Nishimura MT Pevzner SJ Donovan SE Ghamsari L Santhanam B Romero V Poulin MM Gebreab F Gutierrez BJ Tam S Monachello D Boxem M Harbort CJ McDonald N Gai L Chen H He Y;European Union Effectoromics Consortium Vandenhaute J Roth FP Hill DE Ecker JR Vidal M Beynon J Braun P Dangl JL 《Science (New York, N.Y.)》2011,333(6042):596-601
Plants generate effective responses to infection by recognizing both conserved and variable pathogen-encoded molecules. Pathogens deploy virulence effector proteins into host cells, where they interact physically with host proteins to modulate defense. We generated an interaction network of plant-pathogen effectors from two pathogens spanning the eukaryote-eubacteria divergence, three classes of Arabidopsis immune system proteins, and ~8000 other Arabidopsis proteins. We noted convergence of effectors onto highly interconnected host proteins and indirect, rather than direct, connections between effectors and plant immune receptors. We demonstrated plant immune system functions for 15 of 17 tested host proteins that interact with effectors from both pathogens. Thus, pathogens from different kingdoms deploy independently evolved virulence proteins that interact with a limited set of highly connected cellular hubs to facilitate their diverse life-cycle strategies. 相似文献
393.
Beta thalassemia trait: detection at birth 总被引:1,自引:0,他引:1
The synthesis of alpha, beta, and gamma chains in samples of cord blood was measured by the incorporation of leucine labeled with carbon-14 into these chains. In a newborn affected with beta thalassemia trait, the presence of one beta thalassemia gene was revealed on the 1st day of life by the lower specific radioactivity of the beta chain. 相似文献
394.
Irmis RB Nesbitt SJ Padian K Smith ND Turner AH Woody D Downs A 《Science (New York, N.Y.)》2007,317(5836):358-361
It has generally been thought that the first dinosaurs quickly replaced more archaic Late Triassic faunas, either by outcompeting them or when the more archaic faunas suddenly became extinct. Fossils from the Hayden Quarry, in the Upper Triassic Chinle Formation of New Mexico, and an analysis of other regional Upper Triassic assemblages instead imply that the transition was gradual. Some dinosaur relatives preserved in this Chinle assemblage belong to groups previously known only from the Middle and lowermost Upper Triassic outside North America. Thus, the transition may have extended for 15 to 20 million years and was probably diachronous at different paleolatitudes. 相似文献
395.
396.
BZR1 is a transcriptional repressor with dual roles in brassinosteroid homeostasis and growth responses 总被引:3,自引:0,他引:3
He JX Gendron JM Sun Y Gampala SS Gendron N Sun CQ Wang ZY 《Science (New York, N.Y.)》2005,307(5715):1634-1638
397.
Nathan C 《Science (New York, N.Y.)》2002,298(5601):2143-2144
398.
399.
The common carp, Cyprinus carpio, is a large, long-lived, fecund and mobile cyprinid, which evolved in complex inter-braided Ponto-Caspian rivers that experience both springtime flooding and freezing winters. Studies suggest adults often move to productive, shallow lakes and floodplains to spawn because they often lack egg predators and then return to deeper normoxic waters to overwinter. Whether these movements involve individuals consistently selecting, or homing to, the same spawning and refuge lakes as part of a strategy benefiting their reproductive success is unknown. To address this question, we examined the movements of 67 radio-tagged adult carp for 3 years in a watershed with 11 interconnected lakes. Carp were tagged and released into a centrally located, normoxic deep lake in spring and fall. Each spring over 95% of its adults left via a single stream and swam into one of 5 shallow lakes, with most individuals (84%) selecting the same lake(s) in which to spawn each year (median Bhattacharyya affinity coefficient of similarity of 0.82). Young were later found in those lakes without egg predators, which cannot survive winter anoxia. After spawning, carp spent summers moving between productive lakes in an individualistic fashion, presumably foraging, with most (89%) eventually returning to the same deep lake to overwinter (median Bhattacharyya affinity of 1.0). These movements appear to reveal a life-history tactic involving seasonal homing migration, first to a spawning location and later to winter refuges, that is well adapted to productive but highly heterogeneous and interconnected freshwater environments. 相似文献
400.