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Krista Mitchell Michele Barletta Steeve Giguère Jane Quandt David Osborn Eryn Watson Bradley Cohen Karl V. Miller 《Veterinary anaesthesia and analgesia》2021,48(3):356-363
ObjectiveTo compare oxygenation and ventilation in white-tailed deer (Odocoileus virginianus) anesthetized with two treatments with and without oxygen supplementation.Study designRandomized, blinded, crossover study.AnimalsA total of eight healthy adult white-tailed deer weighing 49–62 kg.MethodsEach deer was anesthetized twice intramuscularly: 1) treatment XK, xylazine (2 mg kg–1) and ketamine (6 mg kg–1) and 2) treatment XTZ, xylazine (2 mg kg–1) and tiletamine–zolazepam (4 mg kg–1). With the deer in sternal position, arterial and venous blood was collected before and at 30 minutes during administration of oxygen at 1 L minute–1 through a face mask. PaO2 and heart rate (HR) were compared using two-way repeated measures anova. pH, PaCO2 and lactate concentration were analyzed using mixed-effects linear models, p < 0.05.ResultsWhen breathing air, PaO2 was < 80 mmHg (10.7 kPa) in six and seven deer with XK and XTZ, respectively, and of these, PaO2 was < 60 mmHg (8.0 kPa) in three and five deer, respectively. With oxygen supplementation, PaO2 increased to 128 ± 4 and 140 ± 5 mmHg (17.1 ± 0.5 and 18.7 ± 0.7 kPa), mean ± standard error, with XK and XTZ, respectively (p < 0.001). PaO2 was not significantly different between treatments at either time point. HR decreased during oxygen supplementation in both treatments (p < 0.001). Lactate was significantly lower (p = 0.047) with XTZ than with XK (2.2 ± 0.6 versus 3.5 ± 0.6 mmol L–1) and decreased (p < 0.001) with oxygen supplementation (4.1 ± 0.6 versus 1.6 ± 0.6 mmol L–1). PaCO2 increased in XTZ during oxygen breathing.Conclusions and clinical relevanceTreatments XK and XTZ resulted in hypoxemia, which responded to oxygen supplementation. Both treatments are suitable for immobilization of white-tailed deer under the study circumstances. 相似文献
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