The spatial extent of 20th-century warmth in the context of the past 1200 years

Periods of widespread warmth or cold are identified by positive or negative deviations that are synchronous across a number of temperature-sensitive proxy records drawn from the Northern Hemisphere. The most significant and longest duration feature during the last 1200 years is the geographical extent of warmth in the middle to late 20th century. Positive anomalies during 890 to 1170 and negative anomalies during 1580 to 1850 are consistent with the concepts of a Medieval Warm Period and a Little Ice Age, but comparison with instrumental temperatures shows the spatial extent of recent warmth to be of greater significance than that during the medieval period.     

Infectious prions in the saliva and blood of deer with chronic wasting disease

A critical concern in the transmission of prion diseases, including chronic wasting disease (CWD) of cervids, is the potential presence of prions in body fluids. To address this issue directly, we exposed cohorts of CWD-na?ve deer to saliva, blood, or urine and feces from CWD-positive deer. We found infectious prions capable of transmitting CWD in saliva (by the oral route) and in blood (by transfusion). The results help to explain the facile transmission of CWD among cervids and prompt caution concerning contact with body fluids in prion infections.