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81.
Murray J 《Science (New York, N.Y.)》1911,33(858):873-887
82.
Polar mesospheric clouds are thin layers of nanometer-sized ice particles that occur at altitudes between 82 and 87 kilometers in the high-latitude summer mesosphere. These clouds overlap in altitude with the layer of iron (Fe) atoms that is produced by the ablation of meteoroids entering the atmosphere. Simultaneous observations of the Fe layer and the clouds, made by lidar during midsummer at the South Pole, demonstrate that essentially complete removal of Fe atoms can occur inside the clouds. Laboratory experiments and atmospheric modeling show that this phenomenon is explained by the efficient uptake of Fe on the ice particle surface. 相似文献
83.
Halder GJ Kepert CJ Moubaraki B Murray KS Cashion JD 《Science (New York, N.Y.)》2002,298(5599):1762-1765
The nanoporous metal-organic framework Fe2(azpy)4(NCS)4.(guest) (azpy is trans-4,4'-azopyridine) displays reversible uptake and release of guest molecules and contains electronic switching centers that are sensitive to the nature of the sorbed guests. The switching of this material arises from the presence of iron(II) spin crossover centers within the framework lattice, the sorbed phases undergoing "half-spin" crossovers, and the desorbed phase showing no switching property. The interpenetrated framework structure displays a considerable flexibility with guest uptake and release, causing substantial changes in the local geometry of the iron(II) centers. The generation of a host lattice that interacts with exchangeable guest species in a switchable fashion has implications for the generation of previously undeveloped advanced materials with applications in areas such as molecular sensing. 相似文献
84.
85.
Murray M 《Science (New York, N.Y.)》2003,299(5614):1851-1853
86.
The impact of gene patents on downstream research and innovation are unknown, in part because of a lack of empirical data on the extent and nature of gene patenting. In this Policy Forum, the authors show that 20% of human gene DNA sequences are patented and that some genes are patented as many as 20 times. Unsurprisingly, genes associated with health and disease are more patented than the genome at large. The intellectual property rights for some genes can become highly fragmented between many owners, which suggests that downstream innovators may face considerable costs to gain access to gene-oriented technologies. 相似文献
87.
88.
Darlington RB Royce JM Snipper AS Murray HW Lazar I 《Science (New York, N.Y.)》1980,208(4440):202-204
At follow-up in 1976, low-income children who had attended infant and preschool programs in the 1960's had significantly higher rates of meeting school requirements than did controls, as measured by lower frequency of placement in special education classes and of being retained in grade (held back). 相似文献
89.
90.
Whistler JL Enquist J Marley A Fong J Gladher F Tsuruda P Murray SR Von Zastrow M 《Science (New York, N.Y.)》2002,297(5581):615-620
Recycling of the mu opioid receptor to the plasma membrane after endocytosis promotes rapid resensitization of signal transduction, whereas targeting of the delta opioid receptor (DOR) to lysosomes causes proteolytic down-regulation. We identified a protein that binds preferentially to the cytoplasmic tail of the DOR as a candidate heterotrimeric GTP-binding protein (G protein)-coupled receptor-associated sorting protein (GASP). Disruption of the DOR-GASP interaction through receptor mutation or overexpression of a dominant negative fragment of GASP inhibited receptor trafficking to lysosomes and promoted recycling. The GASP family of proteins may modulate lysosomal sorting and functional down-regulation of a variety of G protein-coupled receptors. 相似文献