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21.
An eight-year-old, female springer spaniel was treated for metastatic insulinoma with a single intravenous dose of 500 mg/m2 streptozotocin (SZN), and pre- and post-treatment diuresis. A tapering dose of corticosteroids was also administered over a 28 day period. SZN and corticosteroid administration resulted in resolution of hypoglycaemia and subsequent development of diabetes mellitus. Further metastases caused cervical spinal pain and the dog was euthanased 118 days after SZN administration. SZN can be safely used for the treatment of canine insulinoma, but, when compared with other published cases, a marked variation in clinical response to this drug exists and further study is warranted. 相似文献
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S C Mooney A A Hayes R E Matus E G MacEwen 《Journal of the American Veterinary Medical Association》1987,191(11):1473-1477
Renal lymphoma was diagnosed, staged, and treated in 28 cats. Renal lymphoma staging was done according to clinical findings: 11 cats had stage-2 lymphomas, 5 had stage-3 lymphomas, 6 had stage-4 lymphomas, and 6 had stage-5 lymphomas. All cats were treated with chemotherapy: 17 cats had a complete response, 9 cats had a partial response, and 2 cats had no response. The cats with stage-2 lymphomas that were FeLV-test negative had the best response to treatment. 相似文献
23.
Kumar KR Li L Yan M Bhaskarabhatla M Mobley AB Nguyen C Mooney JM Schatzle JD Wakeland EK Mohan C 《Science (New York, N.Y.)》2006,312(5780):1665-1669
The susceptibility locus for the autoimmune disease lupus on murine chromosome 1, Sle1z/Sle1bz, and the orthologous human locus are associated with production of autoantibody to chromatin. We report that the presence of Sle1z/Sle1bz impairs B cell anergy, receptor revision, and deletion. Members of the SLAM costimulatory molecule family constitute prime candidates for Sle1bz, among which the Ly108.1 isoform of the Ly108 gene was most highly expressed in immature B cells from lupus-prone B6.Sle1z mice. The normal Ly108.2 allele, but not the lupus-associated Ly108.1 allele, was found to sensitize immature B cells to deletion and RAG reexpression. As a potential regulator of tolerance checkpoints, Ly108 may censor self-reactive B cells, hence safeguarding against autoimmunity. 相似文献
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CASE HISTORY: A mature male tuatara was presented with a history of recurrent cloacal prolapse. CLINICAL AND PATHOLOGICAL FINDINGS: The prolapsed tissue included a 12 mm diameter mass, which histologically showed cords and nodules of neoplastic epithelial cells. DIAGNOSIS: The mass was diagnosed as a squamous cell carcinoma with ulceration of the overlying stratified squamous epithelium and diffuse inflammation of the surrounding dermis. CLINICAL RELEVANCE: This case presented a rare opportunity to investigate squamous cell carcinoma in a long-lived lower vertebrate species. Future recurrence or metastasis of the mass may add useful information to the current base of knowledge of the behaviour of malignant neoplasms in reptiles. 相似文献
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Sarah A. Bekessy Brendan A. Wintle Ascelin Gordon Julian C. Fox Ryan Chisholm Bill Brown Tracey Regan Nick Mooney Steve M. Read Mark A. Burgman 《Biological conservation》2009,142(11):2438-2448
The wedge-tailed eagle is Australia’s largest bird of prey and one of the largest eagles in the world. Aquila audax fleayi is an endemic Tasmanian subspecies isolated for 10,000 years from the nominate subspecies on the Australian mainland. The Tasmanian wedge-tailed eagle is classified nationally and at a State level as endangered due to its small number of breeding pairs, low breeding success and high rate of mortality from unnatural causes. The subspecies experiences mortality throughout its range from shooting, poisoning, trapping, road accidents, electrocutions and collisions with wind turbines, aircraft, fences and overhead wires, which we term ‘un-natural mortality’. A portion of the subspecies’ range is managed for timber production, which can lead to disturbance of nest sites and the loss of nest trees. We use a model of the eagle population from the Bass District in northeast Tasmania to explore the relative importance of different sources of mortality and nesting habitat loss, and the potential for mitigating impacts associated with unnatural mortality, disturbance, nesting habitat loss and human access to forests. We create a habitat map including suitable nest sites and link it to a dynamic landscape population model based on life history traits and disturbance responses. Using the program RAMAS-Landscape, we model alternative forest management scenarios, ranging from no timber harvesting and a natural wildfire regime, to scenarios prescribing native forest harvesting and regeneration and different levels of conversion of native forest to plantation under the same natural wildfire regime. The results indicate that the Tasmanian wedge-tailed eagle is sensitive to unnatural mortality, plantation establishment and native forest harvesting. The predicted decline over the next 160 years (65%) will most likely be driven largely by loss of current and potential future nest sites associated with harvesting activities, exacerbated by unnatural mortality in the wider landscape. Interventions that minimise unnatural mortality, reduce nest disturbance, and retain breeding habitat and nest sites may improve the prospects for the subspecies in the Bass District. If nest disturbance and unnatural mortality continue at the rates modelled here, the species appears to face a high risk of declining substantially in the region. 相似文献
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Soil physical properties affect the establishment of crops; these properties are influenced by cultivation incurred during seedbed preparation and vary greatly depending upon the intensity of applications. However, there is little quantified data concerning the influence of cultivation upon the precise soil structural arrangement and the effects of this on crop establishment. The dynamics of soil macrostructure properties on a range of seedbeds and how they relate to crop establishment are considered in this paper. Significant interactions between cultivation techniques, soil physical properties, the soil macropore structure of the seedbed and the interaction with crop establishment were identified. The relationship between soil structure and crop establishment was highly significant, with increased pore space reducing final establishment numbers. An improvement to a previously developed model (soil quality of establishment (SQE)) was developed following the addition of soil macrostructure properties, accounting for improved predictability of between ca. 6% and 19% of the variation accounted across soil types, environmental conditions. 相似文献
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This investigation examines the effect of manipulating soil microbial community composition and species richness on the development of soil structure over a seven month period in planted (with or without mycorrhizal fungi) and in unplanted macrocosms. The dilution method effectively resulted in soil communities with consistently contrasting levels of species (TRF) richness. In particular, the 10?6 dilution of field soil resulted in less rich communities in bare unplanted soil than did the 10?1 soil dilution. However, this was not the case in planted soils where root activity was a powerful influence on species richness. After seven months, principal components analysis (PCA) separated bacterial community composition primarily on planting regime; planted mycorrhizal, planted non-mycorrhizal and bare soil treatments all contained different bacterial community compositions. A consistent finding in planted and unplanted soils was that aggregate stability was positively correlated with small pore sizes. Mycorrhizal colonisation decreased plant biomass and also resulted in reduced soil bacterial species richness, lower percentage organic matter and smaller pore sizes relative to planted but non-mycorrhizal soils. However, soil aggregate stability and water repellency were increased in these (mycorrhizal) soils probably due to AMF hyphal activities including enmeshment and/or glomalin production. In contrast, bacterial TRF richness was positively correlated with aggregate stability in the bare and non-mycorrhizal planted soils. Soil organic carbon was an important factor in all treatments, but in the bare soil where there was no additional input of labile C from roots, the percentage C could be directly related to fungal TRF richness. The less species rich bare soil contained more organic C than the more species rich bare soil. This suggests a degree of redundancy with regard to mineralisation of organic matter when additional, more utilisable C sources are unavailable. Understanding the effects of microbial diversity on functional parameters is important for advancing sustainable soil management techniques, but it is clear that soil is a dynamic ecosystem. 相似文献