Long-range correlations in the diffuse seismic coda

The late seismic coda may contain coherent information about the elastic response of Earth. We computed the correlations of the seismic codas of 101 distant earthquakes recorded at stations that were tens of kilometers apart. By stacking cross-correlation functions of codas, we found a low-frequency coherent part in the diffuse field. The extracted pulses have the polarization characteristics and group velocities expected for Rayleigh and Love waves. The set of cross-correlations has the symmetries of the surface-wave part of the Green tensor. This seismological example shows that diffuse waves produced by distant sources are sufficient to retrieve direct waves between two perfectly located points of observation. Because it relies on general properties of diffuse waves, this result has potential applications in other fields.     

Systems of knowledge as systems of domination: The limitations of established meaning

The hegemony of Western science, inherent in international development projects, often increases the poverty and oppression of Third World women by pre-empting alternative realities. In African and Asian agrarian societies women grow from 60 to 90% of the food (World Bank, 1989); they hold incredible potential to increase food production. Their ability to operate under more marginal conditions than their male counterparts would seem to indicate that they have developed valuable knowledge— knowledge often generated in response to limited access to the more tangible resources offered by development assistance to male farmers. Recognizing the marginalization of women in the Third World, the Women in Development (WID) network was established during the 1970's to produce knowledge about women, fill in the gaps, and set the record straight. But knowledge creation for these purposes leaves underlying paradigms of Western science-based development unquestioned. Research from a feminist standpoint is used to challenge the objectivity and reliability of EuroAmerican development science. To date, WID has documented and analyzed the causes and consequences of Third World women's oppression with no substantial results to end them. Alternatively, feminist research validates women's perceptions of their reality, helping ordinary people to understand the connections between their experiences and broader social, economic, and political struggles. The paper emphasizes research pursued in order to act, closely linking knowing to doing to promote the emancipation of oppressed groups. A feminist standpoint is used to privilege the perspective of rural women in developing countries and ask: “What are the implications of the standard EuroAmerican approach to science for maximizing the potential contributions of rural women to agricultural development?” Some of these implications are illustrated with examples from on-farm research in Nigeria. To some extent, implications can be addressed by constructing meanings to structure a symbolic framework that includes female farmers and other disadvantaged groups.     

A physical map of the 1-gigabase bread wheat chromosome 3B

As the staple food for 35% of the world's population, wheat is one of the most important crop species. To date, sequence-based tools to accelerate wheat improvement are lacking. As part of the international effort to sequence the 17-billion-base-pair hexaploid bread wheat genome (2n = 6x = 42 chromosomes), we constructed a bacterial artificial chromosome (BAC)-based integrated physical map of the largest chromosome, 3B, that alone is 995 megabases. A chromosome-specific BAC library was used to assemble 82% of the chromosome into 1036 contigs that were anchored with 1443 molecular markers, providing a major resource for genetic and genomic studies. This physical map establishes a template for the remaining wheat chromosomes and demonstrates the feasibility of constructing physical maps in large, complex, polyploid genomes with a chromosome-based approach.     

On the origin of interictal activity in human temporal lobe epilepsy in vitro

The origin and mechanisms of human interictal epileptic discharges remain unclear. Here, we describe a spontaneous, rhythmic activity initiated in the subiculum of slices from patients with temporal lobe epilepsy. Synchronous events were similar to interictal discharges of patient electroencephalograms. They were suppressed by antagonists of either glutamatergic or gamma-aminobutyric acid (GABA)-ergic signaling. The network of neurons discharging during population events comprises both subicular interneurons and a subgroup of pyramidal cells. In these pyramidal cells, GABAergic synaptic events reversed at depolarized potentials. Depolarizing GABAergic responses in neurons downstream to the sclerotic CA1 region contribute to human interictal activity.     

Plague bacteria target immune cells during infection

The plague is caused by the bacterium Yersinia pestis. Plague bacteria are thought to inject effector Yop proteins into host cells via the type III pathway. The identity of the host cells targeted for injection during plague infection is unknown. We found, using Yop beta-lactamase hybrids and fluorescent staining of live cells from plague-infected animals, that Y. pestis selected immune cells for injection. In vivo, dendritic cells, macrophages, and neutrophils were injected most frequently, whereas B and T lymphocytes were rarely selected. Thus, it appears that Y. pestis disables these cell populations to annihilate host immune responses during plague.