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61.
Hori Y Takusagawa F Ikadai H Uechi M Hoshi F Higuchi S 《American journal of veterinary research》2007,68(10):1058-1063
OBJECTIVE: To investigate the diuretic effects, tolerability, and adverse effects of furosemide and torsemide after short- and long-term administration in healthy dogs. ANIMALS: 8 mixed-breed dogs. PROCEDURES: In a crossover study, furosemide (2 mg/kg), torsemide (0.2 mg/kg), or placebo (bifidobacterium [1 mg/kg]) was administered orally to each dog every 12 hours for 14 days. Blood and urine samples were collected before the study (baseline data) and at intervals on the 1st (short-term administration) and 14th day (long-term administration) of treatment for assessment of urine volume and specific gravity and selected clinicopathologic variables including BUN, creatinine, and aldosterone concentrations, and creatinine clearance. RESULTS: Compared with the baseline value, short-term administration of furosemide or torsemide immediately increased urine volume significantly; after long-term administration of either drug, urine specific gravity decreased significantly. Compared with the effect of placebo, the 24-hour urine volume was significantly increased after short-term administra-tion of furosemide or torsemide. In addition, it was significantly increased after long-term administration of torsemide, compared with that of short-term administration. Long-term administration of furosemide or torsemide increased the BUN and plasma creatinine con-centrations, compared with the baseline value. Compared with the baseline value, plasma aldosterone concentration was significantly increased after long-term administration of either drug and was significantly higher after torsemide treatment than after furosemide treatment. CONCLUSIONS AND CLINICAL RELEVANCE: In dogs, diuretic resistance developed after 14 days of furosemide, but not torsemide, administration; however, both loop diuretics were associated with increased BUN and plasma creatinine concentrations, compared with values before treatment. 相似文献
62.
Mami UEMURA Hitomi IGARASHI Aisa OZAWA Naoki TSUNEKAWA Masamichi KUROHMARU Masami KANAI-AZUMA Yoshiakira KANAI 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(5):587-591
In early embryogenesis, the posteroventral foregut endoderm gives rise to the
budding endodermal organs including the liver, ventral pancreas and gallbladder during
early somitogenesis. Despite the detailed fate maps of the liver and pancreatic
progenitors in the mouse foregut endoderm, the exact location of the gallbladder
progenitors remains unclear. In this study, we performed a DiI fate-mapping analysis using
whole-embryo cultures of mouse early somite-stage embryos. Here, we show that the majority
of gallbladder progenitors in 9–11-somite-stage embryos are located in the lateral-most
domain of the foregut endoderm at the first intersomite junction level along the
anteroposterior axis. This definition of their location highlights a novel entry point to
understanding of the molecular mechanisms of initial specification of the gallbladder. 相似文献
63.
Sex and age differences in meat composition of Yeso sika deer (Cervus nippon yesoensis) reared for a short period after capture in the wild
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Maki Hayashida Kousaku Souma Kazuki Sugo Shin‐ichi Araki Fumiaki Ishizaka Masami Ueda Takamasa Kasai Takayoshi Masuko 《Animal Science Journal》2015,86(2):207-213
Yeso sika deer captured in winter around Lake Akan in Hokkaido were reared for 8–10 months at Tokyo University of Agriculture in Abashiri. Six 1‐year‐old females and males and six 2‐year‐old or older (adult) females and males were slaughtered and their carcasses were processed. The chemical composition, mineral contents and fatty acid composition of the loin were measured. No marked influence of gender or age was noted in the chemical composition of loin. In the mineral contents, significant differences were noted. The potassium and sulfur contents were lower and the sodium content was higher in adult deer meat (P < 0.05, respectively) and the potassium content was higher in male deer meat (P < 0.05). Arsenic, cadmium or lead were not detected. In the unsaturated fatty acid, a significant interaction was detected (P < 0.05), and it was high in 1‐year‐old female deer meat and low in 1‐year‐old male deer meat. Significant gender or age differences were noted only in the mineral contents in the loin of deer reared for a short period after capture. 相似文献
64.
Comparison of the diuretic effect of furosemide by different methods of administration in healthy dogs
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65.
66.
Abstract The phosphate sorption (P sor) capacity of soils increased when the soils were reduced (Willet and Higgins, Aust. J. Soil Res., 16, 319–326, 1978). The present study aimed at the elucidation of this mechanism using Na2S2O4 and 5 different soils. The P sor of the 5 soils increased with the addition of a small amount of Na2S2O4. Fe(II) was released from the soils with the addition of the same small amount of Na2S2O4. Furthermore, when the amount of FeCl2 corresponding to the amount of Fe(II) released along with the small amount of Na2S2O4 was added, the P sor of the soil increased. However, the P sor of the lowland soils, of which the hydrous Fe oxide content was lower than the others, decreased when the amount of Na2S2O4 addition was increased up to 150–200 g kg?1. Based on these results, the following process is inferred for the increase in the P sor of the soils when they are reduced. Hydrous Fe oxide in soil takes the form of very fine, high-density particles and reacts with P mainly on their surface. When a small amount of Na2S2O4 is added, the hydrous Fe oxide is partially reduced, dissolved and finally re-precipitates with P by oxidation with O2 from the air during the experiment. 相似文献
67.
Tomomi TANAKA Satoshi OHKURA Yoshihiro WAKABAYASHI Takenobu KUROIWA Kiyosuke NAGAI Natsumi ENDO Akira TANAKA Hisanori MATSUI Masami KUSAKA Hiroaki OKAMURA 《The Journal of reproduction and development》2013,59(6):563-568
The aim of the present study was to determine if the estradiol-induced luteinizing
hormone (LH) surge is influenced by the constant exposure to TAK-683, an
investigational metastin/kisspeptin analog, that had been established to depress the
pulsatile gonadotropin-releasing hormone (GnRH) and LH secretion in goats.
Ovariectomized goats subcutaneously received TAK-683 (TAK-683 group, n=6) or vehicle
(control group, n=6) constantly via subcutaneous implantation of an osmotic pump.
Five days after the start of the treatment, estradiol was infused intravenously in
both groups to evaluate the effects on the LH surge. Blood samples were collected at
6-min intervals for 4 h prior to the initiation of either the TAK-683 treatment or
the estradiol infusion, to determine the profiles of pulsatile LH secretion. They
were also collected at 2-h intervals from –4 h to 32 h after the start of estradiol
infusion for analysis of LH surges. The frequency and mean concentrations of LH
pulses in the TAK-683 group were remarkably suppressed 5 days after the start of
TAK-683 treatment compared with those of the control group (P<0.05). On the other
hand, a clear LH surge was observed in all animals of both groups. There were no
significant differences in the LH concentrations for surge peak and the peak time of
the LH surge between the TAK-683 and control groups. These findings suggest that the
effects of continuous exposure to kisspeptin or its analog on the mechanism(s) that
regulates the pulsatile and surge mode secretion of GnRH/LH are different in
goats. 相似文献
68.
Masami Numata Takashi Kondo Yasuo Nambo Yasunaga Yoshikawa Kiyotaka Watanabe Koichi Orino 《Animal Science Journal》2013,84(12):782-789
Antibody (immunoglobulin G (IgG), IgM or IgA) levels relative to ferritin in six foal sera (three male and three female) after birth (day 0 and 2, 6, 10, 20, 28, 36, 40, 52 and 56 weeks of age) were semi‐quantitatively measured with normalization with antibody activity to ferritin in one adult horse serum. After addition of horse spleen ferritin to the serum sample, the complex formed between antibodies to ferritin in the serum and ferritin was co‐immunoprecipitated using antibody to horse spleen ferritin. Antibody classes of the co‐immnoprecipitate were detected with antibodies specific for horse IgG, IgM or IgA heavy chain. Six adult horse serum samples were found to have ferritin‐binding activities in all immunoglobulin classes examined. Although ferritin antibody activities (IgG, IgM and IgA) were scant in the foal sera before sucking colostrum (day 0), their activities increased at 2 weeks of age. IgG antibodies showed a biphasic response and IgM antibody activity increased up to 40 weeks of age. Antibody (IgG, IgM and IgA) activities to ferritin in three colostrum samples were significantly higher than in adult horse serum samples. These results demonstrate that antibody to ferritin in foal serum is derived from colostrum after birth and is produced thereafter. 相似文献
69.
Abstract The cold-hardiness of Liriomyza chinensis pupae was measured in the laboratory by observing pupal mortality at low temperatures. Pupal mortality increased with decreasing temperature and with extended cold exposure time. No recently pupated pupae (6 h) were able to survive after 16 days of chilling at 0, 2.5 and 5°C, but 42.9% survival was observed at 10°C. Pupae at different developmental stages showed significant difference in mortality, with very low levels of mortality observed for older pupae (4 and 7 days) after exposure to 0°C for 16 days. The lethal time for 50% survival (LT50) increased with increasing age of pupae. LT50 for 4-day-old pupae exposed to 0°C was 52.1 days. Analysis of mean temperatures at several localities indicated that L. chinensis is able to overwinter outdoors in southern regions, but is unable to overwinter in open fields in northern regions of Japan, suggesting that overwintering in these regions would only occur in greenhouses. 相似文献
70.
Bacillus amyloliquefaciens IUMC7 isolated from mushroom compost inhibited growth of Fusarium oxysporum f. sp. lycopersici (FOL) on culture plates, and a culture supernatant of IUMC7 inhibited in vitro germ tube elongation of FOL. When compared with control soils, mushroom compost inoculated with IUMC7 significantly reduced disease severity caused by FOL in tomato plants. PCR tests for expression of PR genes indicated that IUMC7 did not induce resistance in tomato plants. These results suggested that the suppression of disease was mainly caused by antimicrobial compounds produced by IUMC7. 相似文献