Comparison of efficacy and toxicity of doxorubicin and mitoxantrone in combination chemotherapy for canine lymphoma

Forty-four dogs with multicentric lymphoma were treated using a cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) induction protocol or treated using a cyclophosphamide, mitoxantrone, vincristine, and prednisolone (CMOP) induction protocol. There was no statistical difference in signalment and the presence of historical negative prognostic factors between the groups. The median progression-free survival (PFS) in the CHOP and CMOP groups were 222 d and 162 d, respectively (P = 0.75). The median survival time (MST) of dogs in CHOP and CMOP groups were 318 d and 242 d, respectively (P = 0.63). Anorexia and diarrhea episodes were significantly higher in the CHOP group than in the CMOP group (P = 0.02 and P = 0.01, respectively). These results suggest that the CMOP protocol provides similar PFS, MST and causes fewer side effects compared to the CHOP protocol. Therefore, the CMOP protocol may be another treatment choice for canine multicentric lymphoma.     

中间锦鸡儿花水浸提液对三种作物种子萌发及幼苗生长的化感作用

以中间锦鸡儿和玉米、苏丹草、高丹草种子为试材,以蒸馏水为对照,采用培养皿滤纸法,研究了不同梯度(0.5、1.0、5.0、10.0、25.0mg·mL~(-1))中间锦鸡儿花水浸提液对3种受体作物种子萌发及幼苗生长的影响,以期对农林复合系统生产和构建提供理论依据和有益参考。结果表明:随着中间锦鸡儿花水浸提液质量浓度的增加,受体作物玉米、苏丹草、高丹草种子的平均发芽率和发芽指数均表现"低浓度促进,高浓度抑制"效应,但不同质量浓度水浸提液对3种农作物种子发芽的影响有差异性,在质量浓度为1.0mg·mL~(-1)时,3种农作物的种子相对发芽率间无显著差异(P0.05),除玉米外,另外2种受体作物种子的平均发芽率均表现为促进作用,且对高丹草的促进作用最大,RI=13.70%;在高浓度浸提液(C≥5.0mg·mL~(-1))处理下3种受体作物种子的发芽指数与对照均表现显著差异(P0.05)。玉米、苏丹草和高丹草的胚根、胚芽对中间锦鸡儿花水浸提液的化感效应均表现为"浓度效应";3种受体作物的苗高随着浸提液处理浓度的增大表现为"低促高抑",高浓度的浸提液对高丹草幼苗高度的抑制作用最强。花水浸提液对苏丹草和高丹草的幼苗干重化感效应表现为"低促高抑"效应,而对玉米幼苗干重表现为"高浓度抑制"效应。中间锦鸡儿花水浸提液对3种受体作物的化感作用综合效应大小依次为高丹草玉米苏丹草。     

An 8bp indel in exon 1 of Ghrelin gene associated with chicken growth

Ghrelin, acts as the endogenous ligand for growth hormone secretagogues receptor (GHS-R), is a novel growth hormone (GH) releasing peptide with reported effects on food intake in chickens. In this study, an 8 bp indel polymorphism in exon 1 of the chicken Ghrelin (cGHRL) gene was genotyped in a F(2) designed full-sib population to analyze its associations with chicken growth and carcass traits. Later, mRNA level in the proventriculus was determined by real-time PCR to reveal the expression feature of cGHRL gene. Result showed that this 8 bp indel was significantly associated with body weight at the age of 28 days (BW28) and 56 days (BW56), eviscerated weight (EW) and leg muscle weight (LMW) (P<0.05), highly significantly associated with hatch weight (HW), BW14, 21, 35, 42, 49, 90 and body length (BL), dressed weight (DW), eviscerated weight with giblet (EWG), wing weight (WW), breast muscle weight (BMW) and head and neck weight (HNW) (P<0.01). Meanwhile, A allele (with 'CTAACCTG') was positive for chicken growth as individuals with AA genotype had the highest value of all traits. Analysis on cGhrelin mRNA level revealed that it differed significantly among individuals with three genotypes (P<0.05). Individuals with AB genotype had the highest mRNA level, whereas that of AA had the lowest one. It was concluded that this 8 bp indel of cGHRL gene was significantly associated with most body weight and body composition traits, and negative effect of endogenous Ghrelin on chicken growth were indicated by this study.     

四川省凉山黑绵羊疫病防控现状及对策

凉山黑绵羊是我国十大优异畜禽遗传资源之一。通过问卷调查、实地调研和查阅资料等方式,发现近年来凉山黑绵羊产业得到了前所未有的发展,但疫病防控也面临着羊病流行情况复杂、免疫效果不佳、疫病监测预警能力弱等诸多短板,由此提出提高疫病综合防控能力和养殖户疫病防控意识,优化科学合理的免疫程序,加强监测预警能力建设,科学防治寄生虫病等防控策略,旨在提升凉山黑绵羊产业疫病防控能力,助力乡村振兴,保障国家核心畜禽种源安全。     

网络驱动的协同设计三维几何模型共享技术

为解决网络驱动的协同设计三维几何模型共享技术的实现问题,提出一种基于特征流的混合式3D几何模型共享机制,提出了基于多粒度的产品几何模型数据结构描述方法和面向模型局部操作的"游历-查询"特征的历史记录来重构模型的特征建模方法。建立了网络驱动的、基于CORBA/JAVA中间插件的3D几何模型特征信息同步传输和共享平台,CORBA/JAVA平台支持多用户、分布数据管理、消息传输、网络通讯以及可扩展性,通过该平台实现了三维模型的实时传输和共享。     

药用红花生长发育规律的研究

根据药用红花根、叶、茎、分枝、花及生长中心的变化特点，将药用红花个体发育过程划分为莲座期、伸长期、分枝期、开花期及种子成熟期５个生育时期，红花一生有５２叶左右，以伸长期出叶速度最快，平均每２．０天出一叶，这一时期形成１７叶左右。叶面积在生育前期较小，至分枝期达最高值（４月中旬，３０７４．５ｃｍ＾２／ｐｉａｎｔ，叶面积指数５．５），且保持较高叶面积一定时间，以利于分枝和花的发育。红花在分枝期净同化率     

植物新品种保护在企业科技进步中的作用

种子企业要在种子竞争中立于不败之地，就必须积极加快科研开发的步伐，全面启动品种创新，培育出更有竞争力的农作物新品种，才能使企业步入健康发展的轨道。同时对获得的植物新品种还应该认真加强保护，这样既保障了企业的应有权益，也激励了农业技术持续创新，规范了市场经济秩序，从而发挥知识产权为企业带来的经济效益，促使企业的科技进步。     

LABORATORY INVESTIGATION OF ESSENTIAL CHARACTERISTICS PARAMETERS FOR THE INDUCED-NOZZLE DEVICE

The standoff of a submerged jet is smaller than a non-submerged jet in general. In order to increase the standoff of a submerged jet, the induced-nozzle device is presented with its inducing mechanism analysed in this paper. Under the various inducing medium, the effect of the ratio d2/d1 upon the device's properties is measured. Some reasonable parameters are given. When d2/d1=2.0, approximate straight region of the curve of the jet center line stagnation pressure varying with the standoff is L/d1= l0~12 for inducing air. The induced-nozzle device is compared with the conventional nozzle for shotting some samples. Several applied possibilities of the device are discussed.     

西宁莴苣原种生产技术

1品种特性 叶披针形,绿色,先端纯尖,叶全缘,叶面微皱,无刺毛,无蜡粉.株高57cm,开展度44cm,肉质根棍棒形,不宜开裂.茎皮绿白,茎肉浅绿色,长52cm,粗5cm.种株高121cm,株幅40cm.头状花序,花黄色,种子长椭圆形,黑褐色.生育期169d.     

EQ6110客车电动AMT换挡策略

分析了客车换挡特点和原型车及C220发动机的特性，基于AVL Cruise软件建立了客车仿真模型，提出了适合于该客车电动式机械自动变速器换挡策略。仿真结果表明，在不降低原车动力性的条件下，设计的双参数换挡策略与单参数换挡相比可降低油耗2．4L／（100km），节油率达6．7％。单参数速度换挡仿真结果与试验结果基本一致，证明换挡策略是可信的。