Inhibition of hepatitis B virus replication by drug-induced depletion of nucleocapsids

Chronic hepatitis B virus (HBV) infection is a major cause of liver disease. Only interferon-alpha and the nucleosidic inhibitors of the viral polymerase, 3TC and adefovir, are approved for therapy. However, these therapies are limited by the side effects of interferon and the substantial resistance of the virus to nucleosidic inhibitors. Potent new antiviral compounds suitable for monotherapy or combination therapy are highly desired. We describe non-nucleosidic inhibitors of HBV nucleocapsid maturation that possess in vitro and in vivo antiviral activity. These inhibitors have potential for future therapeutic regimens to combat chronic HBV infection.     

A fossil lemur from the Oligocene of Pakistan

In the absence of a comprehensive fossil record, the origin and early evolution of Malagasy lemurs have been subject to much uncertainty. We report here the discovery of a strepsirrhine fossil with strong cheirogaleid lemur affinities, Bugtilemur mathesoni gen. et sp. nov., from early Oligocene deposits of the Bugti Hills (Balochistan, Pakistan). Bugtilemur represents the earliest record of Lemuriformes, which hence appear to have already diversified outside of Madagascar at least 30 million years ago. This fossil clearly enhances the critical role of the Indian subcontinent in the early diversification of lemurs and constrains paleobiogeographic models of strepsirrhine lemur evolution.     

Building programmable jigsaw puzzles with RNA

One challenge in supramolecular chemistry is the design of versatile, self-assembling building blocks to attain total control of arrangement of matter at a molecular level. We have achieved reliable prediction and design of the three-dimensional structure of artificial RNA building blocks to generate molecular jigsaw puzzle units called tectosquares. They can be programmed with control over their geometry, topology, directionality, and addressability to algorithmically self-assemble into a variety of complex nanoscopic fabrics with predefined periodic and aperiodic patterns and finite dimensions. This work emphasizes the modular and hierarchical characteristics of RNA by showing that small RNA structural motifs can code the precise topology of large molecular architectures. It demonstrates that fully addressable materials based on RNA can be synthesized and provides insights into self-assembly processes involving large populations of RNA molecules.     

Veterinary administration in the Rhineland--yesterday and today

The public veterinary administration was founded in July 1817 by the "Supreme Act" and developed from the public medical administration during the first half of the 19th century to finally an adequate position in 1913. In the beginning prior objectives were animal disease campaigns and participation in animal breeding activities. Towards the end of the last century the public veterinary administration also dealt with hygiene control concerning food of animal origin and meat hygiene. Further fields of activities followed, for example the control of the disposal of animal carcases, trade with animal drugs, vaccines and feedstuff, protection of animals and poultry meat hygiene. It was of special importance to the medium level of the public veterinary administration when in 1981 a chemist engaged in the supervision of food for human consumption was employed by the "Regierungspr?sident" Cologne. It was then possible to lump together both control in the complete field of supervision of food for human consumption and public veterinary administration.