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391.
T Honoré S N Davies J Drejer E J Fletcher P Jacobsen D Lodge F E Nielsen 《Science (New York, N.Y.)》1988,241(4866):701-703
The N-methyl-D-aspartate (NMDA)-subtype of glutamate receptors has been well described as a result of the early appearance of NMDA antagonists, but no potent antagonist for the "non-NMDA" glutamate receptors has been available. Quinoxalinediones have now been found to be potent and competitive antagonists at non-NMDA glutamate receptors. These compounds will be useful in the determination of the structure-activity relations of quisqualate and kainate receptors and the role of such receptors in synaptic transmission in the mammalian brain. 相似文献
392.
Summary Dihaploid populations from 20 varieties and 11 breeding lines ofSolanum tuberosum differed greatly in the occurrence and frequency of mutant phenotypes, in tuberization, flowering, pollen stainability, 2n-pollen
production and resistance toGlobodera rostochiensis pathotype Ro-1. One population contained up to 61.7% lethal mutants: 39.1% of the total of 5377 dihaploids obtained did not
tuberize, and 32.4% of 825 vigorous dihaploids did not flower. Of 825 vigorous dihaploids, 26.9 and 3.9% respectively had
a pollen stainability higher than 20 and 60%. Among 222 dihaploids with a pollen stainability higher than 20%. 23.0% produced
some 2n-pollen and none of these had a stainability higher than 60%. Among the dihaploid populations investigated the proportion
of resistant to susceptible dihaploids ranged from 8:26 to 62:8. 相似文献
393.
Toxicity in three dogs from accidental oral administration of a topical endectocide containing moxidectin and imidacloprid 总被引:1,自引:1,他引:0
Three dogs were presented with a history of oral administration of a topical endectocide containing imidacloprid and moxidectin. They were diagnosed with imidacloprid and moxidectin intoxication, having ingested doses ranging from 7.5 to 1.4 mg/kg of imidacloprid and 1.9 to 2.8 mg/kg of moxidectin. The three dogs were affected to different degrees of severity, but all displayed signs of ataxia, generalised muscle tremors, paresis, hypersalivation and disorientation. Temporary blindness occurred in two cases. The three dogs were tested for the presence of the multi-drug resistance 1 gene deletion, which can cause an increased sensitivity to the toxic effects of moxidectin, and were found to be negative. Treatment included gastrointestinal decontamination, intravenous fluid therapy and benzodiazepines to control muscle tremors. All three dogs made a complete recovery within 48 h of ingestion. 相似文献
394.
Incidence of lymphoma in a captive-bred colony of hamadryas baboons (Papio hamadryas) 总被引:1,自引:1,他引:0
LE Graves A Hennessy NS Sunderland SJ Heffernan SE Thomson 《Australian veterinary journal》2009,87(6):238-243
Objective To assess the incidence of lymphoma and wasting-related deaths in the National Baboon Colony of Australia and relate it to the presence of simian T-cell lymphotrophic virus 1 (STLV-1) infection.
Design and procedure The records of all animals that had died since establishment of the National Baboon Colony in Australia were reviewed retrospectively. The clinical signs and histopathological findings were recorded and assessed to determine the involvement of lymphoma in the deaths. The presence of STLV-1 was recorded if known and correlated with the STLV-1 status of the colony.
Results Of the deaths from disease or illness, 53% were diagnosed as or suspected to be lymphoma, occurring in mature animals with no sex predisposition. The most common presentation was rapidly occurring generalised lymphadenomegaly.
Conclusions This study has described a relatively high prevalence of lymphoma in a colony of captive-bred baboons, and it is evident that STLV-1 may play a role in the disease. Management practices in baboon colonies need to take into account the possible presence of STLV-1 and aim to reduce the transmission of the virus by preventing sexual contact between positive and negative animals. Lymphoma needs to be considered as one of the more common causes of wasting and death. 相似文献
Design and procedure The records of all animals that had died since establishment of the National Baboon Colony in Australia were reviewed retrospectively. The clinical signs and histopathological findings were recorded and assessed to determine the involvement of lymphoma in the deaths. The presence of STLV-1 was recorded if known and correlated with the STLV-1 status of the colony.
Results Of the deaths from disease or illness, 53% were diagnosed as or suspected to be lymphoma, occurring in mature animals with no sex predisposition. The most common presentation was rapidly occurring generalised lymphadenomegaly.
Conclusions This study has described a relatively high prevalence of lymphoma in a colony of captive-bred baboons, and it is evident that STLV-1 may play a role in the disease. Management practices in baboon colonies need to take into account the possible presence of STLV-1 and aim to reduce the transmission of the virus by preventing sexual contact between positive and negative animals. Lymphoma needs to be considered as one of the more common causes of wasting and death. 相似文献
395.
Let MB Jacobsen C Sørensen AD Meyer AS 《Journal of agricultural and food chemistry》2007,55(5):1773-1780
In this study fish oil was incorporated into commercial homogenized milk using different homogenization temperatures and pressures. The main aim was to understand the significance of homogenization temperature and pressure on the oxidative stability of the resulting milks. Increasing homogenization temperature from 50 to 72 degrees C decreased droplet size only slightly, whereas a pressure increase from 5 to 22.5 MPa decreased droplet size significantly. Surprisingly, emulsions having small droplets, and therefore large interfacial area, were less oxidized than emulsions having bigger droplets. Emulsions with similar droplet size distributions, but resulting from different homogenization conditions, had significantly different oxidative stabilities, indicating that properties of significance to oxidation other than droplet size itself were affected by the different treatments. In general, homogenization at 72 degrees C appeared to induce protective effects against oxidation as compared to homogenization at 50 degrees C. The results thus indicated that the actual composition of the oil-water interface is more important than total surface area itself. 相似文献