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An aqueous ethanol extract of Bergenia crassifolia rhizomes strongly inhibited human pancreatic lipase activity and increased scavenging of DPPH free radicals in vitro. Chromatographic separation of this extract led to isolation of the hydrolysable tannins (+)-catechin 3,5-di-O-gallate () and (+)-catechin 3-O-gallate (). This is the first report of the isolation of compound 1 from plant material. This compound strongly inhibited human pancreatic lipase (with an IC50 value of 0.42 μg/ml) and exhibited a remarkable free radical-scavenging ability (with an SC50 value of 1.04 μg/ml). The chemical structures of 1 and 2 were elucidated using MS, NMR and chemical approaches. 相似文献
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Two new species of Rhinebothrium (Cestoda, Rhinebothriidea) from potamotrygonid stingrays in the Neotropical region are herein described, which raises the total number of Rhinebothrium species known from Neotropical freshwaters to five. Rhinebothrium corbatai sp. n., and Rhinebothrium mistyae sp. n. were both collected from Potamotrygon motoro (Müller et Henle), captured in four tributaries of the Paraná River in Santa Fé Province, Argentina. The new species can be distinguished from their congeners, and from each other, by a combination of various features, including worm size (length and number of proglottids), number of loculi per bothridium, microthrix pattern, size of the cirrus sac, and the extent of the vas deferens. The discovery of these new species from P. motoro supports the pattern of high host specificity in this cestode genus, and reinforces the notion that some of the previous records of the enigmatic R. paratrygoni may correspond to new species of Rhinebothrium yet to be described. 相似文献
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This article characterizes poorly studied soils of Bering Island (in the Commander Islands) that formed on the derivatives
of volcanic-sedimentary rocks and tuffs in a cold oceanic climate. The alfehumic process that is dominant in the island soils
has considerable specificity. A high content of nonsilicate forms of iron, aluminum, and aggressive organic matter against
a background of small annual precipitation in the form of drizzle leads to a short migration path of alfehumic compounds and
their fixation in the organic-accumulative part of the profile in the form of original spherical aggregates. In the distribution
of derivatives of rock-containing components that are capable of bleaching (aleurolites and acidic volcanic glass), spatial
heterogeneity promotes the formation of combinations and mosaics of podburs and podzols. 相似文献
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Preston RA Hildebrand CE Purcell GH Ellis J Stelzried CT Finley SG Sagdeev RZ Linkin VM Kerzhanovich VV Altunin VI Kogan LR Kostenko VI Matveenko LI Pogrebenko SV Strukov IA Akim EL Alexandrov YN Armand NA Bakitko RN Vyshlov AS Bogomolov AF Gorchankov YN Selivanov AS Ivanov NM Tichonov VF Blamont JE Boloh L Laurans G Boischot A Biraud F Ortega-Molina A Rosolen C Petit G 《Science (New York, N.Y.)》1986,231(4744):1414-1416
A global array of 20 radio observatories was used to measure the three-dimensional position and velocity of the two meteorological balloons that were injected into the equatorial region of the Venus atmosphere near Venus midnight by the VEGA spacecraft on 11 and 15 June 1985. Initial analysis of only radial velocities indicates that each balloon was blown westward about 11,500 kilometers (8,000 kilometers on the night side) by zonal winds with a mean speed of about 70 meters per second. Excursions of the data from a model of constant zonal velocity were generally less than 3 meters per second; however, a much larger variation was evident near the end of the flight of the second balloon. Consistent systematic trends in the residuals for both balloons indicate the possibility of a solar-fixed atmospheric feature. Rapid variations in balloon velocity were often detected within a single transmission (330 seconds); however, they may represent not only atmospheric motions but also self-induced aerodynamic motions of the balloon. 相似文献
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Sylantyev S Savtchenko LP Niu YP Ivanov AI Jensen TP Kullmann DM Xiao MY Rusakov DA 《Science (New York, N.Y.)》2008,319(5871):1845-1849
The synaptic response waveform, which determines signal integration properties in the brain, depends on the spatiotemporal profile of neurotransmitter in the synaptic cleft. Here, we show that electrophoretic interactions between AMPA receptor-mediated excitatory currents and negatively charged glutamate molecules accelerate the clearance of glutamate from the synaptic cleft, speeding up synaptic responses. This phenomenon is reversed upon depolarization and diminished when intracleft electric fields are weakened through a decrease in the AMPA receptor density. In contrast, the kinetics of receptor-mediated currents evoked by direct application of glutamate are voltage-independent, as are synaptic currents mediated by the electrically neutral neurotransmitter GABA. Voltage-dependent temporal tuning of excitatory synaptic responses may thus contribute to signal integration in neural circuits. 相似文献