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排序方式: 共有195条查询结果,搜索用时 15 毫秒
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Isotani M Ishida N Tominaga M Tamura K Yagihara H Ochi S Kato R Kobayashi T Fujita M Fujino Y Setoguchi A Ono K Washizu T Bonkobara M 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2008,22(4):985-988
BACKGROUND: Imatinib mesylate is a small molecule targeted at dysregulated protein-tyrosine kinase. Mutation of c-kit exon 11, which induces constitutive phosphorylation of KIT, is one of the mechanisms for the development or progression of mast cell tumor (MCT) in dogs. The purpose of this study was to examine the therapeutic potential of imatinib mesylate in canine MCT. HYPOTHESIS: Imatinib mesylate has activity against MCT in dogs, and response to treatment can be correlated to presence of mutation within exon 11 of c-kit. ANIMALS: Twenty-one dogs with MCT with gross tumor burden and median tumor size of 7.2 cm (range, 1.0-25.3 cm) before treatment. METHODS: Tumors were analyzed for mutation of c-kit exon 11. Imatinib mesylate was administered PO to the dogs at a dose of 10 mg/kg daily for 1-9 weeks. RESULTS: Ten of 21 dogs (48%) had some beneficial response to imatinib mesylate treatment within 14 days of treatment initiation. All 5 dogs with a demonstrable c-kit mutation in exon 11 responded to the drug (1 complete remission, 4 partial remission). CONCLUSIONS AND CLINICAL IMPORTANCE: Imatinib mesylate has clinical activity against MCT in dogs. Response could not be predicted based on presence of absence of a mutation in exon 11 of c-kit. 相似文献
174.
Study on aquifer hydraulic properties using tidal response method for future groundwater development
Shirahata Katsushi Yoshimoto Shuhei Tsuchihara Takeo Ishida Satoshi 《Paddy and Water Environment》2019,17(3):531-537
Paddy and Water Environment - The hydraulic properties of an island’s aquifers were studied using a tidal response method. Groundwater is the principal water resource on the studied island,... 相似文献
175.
Naoki Murata Seiichi Ohta Atsushi Ishida Mamoru Kanzaki Chongrak Wachirinrat Taksin Artchawakom Hiroyuki Sase 《Journal of Forest Research》2009,14(4):212-220
In several areas in Northeast Thailand, evergreen and deciduous forests coexist under uniform terrain and climatic conditions.
We compared depth and physical properties of soils between evergreen and deciduous forests in the Sakaerat Environmental Research
Station to clarify what factor determines their distribution. The averaged soil depths were 79 ± 27 cm and 135 ± 58 cm in
the deciduous and evergreen forests, respectively. The soils in the deciduous forests were relatively coarser in soil texture
than those in the evergreen forests, particularly in the surface layers. The average available water capacity of the solum
was lower in the deciduous forest soils (78 mm) than in the evergreen forest soils (123 mm). Compared with the evapotranspiration
from the evergreen forest in the study area, the available water capacity of the evergreen forest soil was almost the same
as the water deficit during the dry season (November–February), while that of the deciduous forest soil was lower and insufficient
to maintain the evapotranspiration. These results suggest that the distribution of deciduous and evergreen forests in the
study area was associated with soil water availability, which mainly depends on soil depth. 相似文献
176.
Polymorphisms of RDH16 and VEGFR1 influence M. trapezius steatosis in Japanese Black carcass 下载免费PDF全文
Takafumi Ishida Kosuke Noda Fortune Ntengwa Jomane Tadaaki Tokunaga 《Animal Science Journal》2017,88(8):1037-1041
The exact cause of steatosis, one of defects in Japanese beef carcasses, has not been elucidated to date, because it is very difficult to diagnose cyclopedically with certain reproducibility due to the bias in the outbreak. Therefore, the objective of this study was to assess the influence of polymorphisms in retinol dehydrogenase 16 (RDH16), myoferlin (MYOF) and vascular endothelial growth factor receptors 1 and 2 (VEGFR1, VEGFR2) on carcass‐graded Musculus trapezius steatosis. For logistic regression analysis, 646 carcasses shipped from 29 farms in Miyazaki, Japan, were used. The GG genotype in RDH16 showed significant odds ratios against AA and AG. In VEGFR1, CT had a significant odds ratio against CC. After evaluating for interaction, highly significant odds ratios were observed in the combinations that included the GG risk genotype in RDH16. It is noteworthy that there was no steatosis in the combination GG (RDH16) and CC (VEGFR1). It may be concluded that there is a possibility that steatosis can be suppressed by the CC genotype in VEGFR1. The current study revealed the influence of genetic polymorphisms on M. trapezius steatosis that had not been reported until now, and may help elucidate the cause of steatosis. 相似文献
177.
Production of anti-virus,viroid plants by genetic manipulations 总被引:1,自引:0,他引:1
Ishida I Tukahara M Yoshioka M Ogawa T Kakitani M Toguri T 《Pest management science》2002,58(11):1132-1136
Many pathogenic plant viruses are RNA viruses, which initiate production of double-stranded RNA intermediates when they replicate in host plant cells. Introduction of double-stranded RNA-specific ribonucleases such as the Schizosaccharomyces pombe derived pac I protein and animal cell derived interferon-induced 2',5'-oligoadenylate synthetase (2-5 Aase)/ribonuclease L (RNase L) system into various plants may make plants resistant to various pathogenic viruses and viroids. We have demonstrated that pac I and 2-5 Aase/RNase L transgenic tobacco plants are resistant to various viruses including tobacco mosaic virus, cucumber mosaic virus and potato virus Y. In addition, pac I transgenic potato plants are resistant to potato spindle tuber viroid. Using Agrobacterium-mediated transformation, we have established a transformation system for chrysanthemum plants and have recently developed pac I transgenic chrysanthemum (Dendranthema grandiflora cv Reagan) resistant to chrysanthemum stunt viroid and have grown them in isolated fields for an evaluation of their effects. 相似文献
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179.
Characterization of feline T and B cells 总被引:1,自引:0,他引:1
T Kuramochi M Takeishi T Ishida K Kato M Ishida 《American journal of veterinary research》1987,48(2):183-185
Feline peripheral-blood lymphocyte populations (n = 22) were examined for the following markers: rosette formation with guinea pig erythrocytes (GPE-T cells), rosette formation with human RBC (HRBC-T cells), rosette formation with sheep RBC, mixed rosette formation with GPE-T cells and HRBC-T cells (total T cells), erythrocyte antibody-complement rosettes, and surface immunoglobulin. An average of 28% +/- 7% (range, 16% to 39%) of the feline lymphocytes formed rosettes with GPE-T cells, and 27% +/- 7% (range, 11% to 36%), with HRBC-T cells. An average of 57% +/- 9% (range, 33% to 75%) of the lymphocytes formed mixed rosettes. The erythrocyte antibody-complement rosette-forming cells and surface immunoglobulin-bearing cells were found in peripheral blood lymphocytes (10% +/- 6% and 24% +/- 8%, respectively). The murine monoclonal antibodies OKT 11 and HuLy-m1, specific for a framework determinant of human E-rosette receptor antigens, cross-reacted with feline cell membrane molecules recognizing a bimolecular complex (45,000 to 50,000 daltons) similar to that described in persons. We investigated the distribution of these E-rosette receptor-like antigens on feline lymphocytes. By complement-mediated lymphocytotoxicity, about 30% of the feline lymphocytes expressed the antigens. When lymphocytes were treated with HuLy-m1 antibody, spontaneous rosette formation with HRBC-T cells was significantly inhibited. 相似文献
180.
Hasegaw T Sato F Ishida N Fukushima Y Mukoyama H 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2000,62(10):1109-1110
A quick method for sex determination of horses was developed. Simultaneous amplification of the equine sex-determining region of the Y chromosome gene (SRY) and amelogenin gene (AMEL) accomplished the determination of the presence of both the Y chromosome and SRY gene. In agarose gel electrophoresis, a normal stallion showed 1 SRY band and 3 AMEL (AMELX, AMELY, and AMELX/AMELY heteroduplex) bands, and a normal mare showed a single AMELX band. In XY-mares, 3 AMEL bands were detected as in a normal stallion, but no SRY band. The present method enables a quick diagnosis for XY-mare prior to cytogenetic analysis. 相似文献