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771.
Radiocarbon dating of petroleum-impregnated bone from tar pits at Rancho La Brea, California 总被引:1,自引:0,他引:1
A liquid-chromatography method has been developed for the separation of amino acids with the same specific activity in radiocarbon from bones impregnated with isotopically dead petroleum compounds found in the La Brea tar pits. This technique permits the application of radiocarbon dating to such bone assemblages. 相似文献
772.
773.
Transmission dynamics of the etiological agent of SARS in Hong Kong: impact of public health interventions 总被引:2,自引:0,他引:2
Riley S Fraser C Donnelly CA Ghani AC Abu-Raddad LJ Hedley AJ Leung GM Ho LM Lam TH Thach TQ Chau P Chan KP Lo SV Leung PY Tsang T Ho W Lee KH Lau EM Ferguson NM Anderson RM 《Science (New York, N.Y.)》2003,300(5627):1961-1966
We present an analysis of the first 10 weeks of the severe acute respiratory syndrome (SARS) epidemic in Hong Kong. The epidemic to date has been characterized by two large clusters-initiated by two separate "super-spread" events (SSEs)-and by ongoing community transmission. By fitting a stochastic model to data on 1512 cases, including these clusters, we show that the etiological agent of SARS is moderately transmissible. Excluding SSEs, we estimate that 2.7 secondary infections were generated per case on average at the start of the epidemic, with a substantial contribution from hospital transmission. Transmission rates fell during the epidemic, primarily as a result of reductions in population contact rates and improved hospital infection control, but also because of more rapid hospital attendance by symptomatic individuals. As a result, the epidemic is now in decline, although continued vigilance is necessary for this to be maintained. Restrictions on longer range population movement are shown to be a potentially useful additional control measure in some contexts. We estimate that most currently infected persons are now hospitalized, which highlights the importance of control of nosocomial transmission. 相似文献
774.
Qazilbash MM Brehm M Chae BG Ho PC Andreev GO Kim BJ Yun SJ Balatsky AV Maple MB Keilmann F Kim HT Basov DN 《Science (New York, N.Y.)》2007,318(5857):1750-1753
Electrons in correlated insulators are prevented from conducting by Coulomb repulsion between them. When an insulator-to-metal transition is induced in a correlated insulator by doping or heating, the resulting conducting state can be radically different from that characterized by free electrons in conventional metals. We report on the electronic properties of a prototypical correlated insulator vanadium dioxide in which the metallic state can be induced by increasing temperature. Scanning near-field infrared microscopy allows us to directly image nanoscale metallic puddles that appear at the onset of the insulator-to-metal transition. In combination with far-field infrared spectroscopy, the data reveal the Mott transition with divergent quasi-particle mass in the metallic puddles. The experimental approach used sets the stage for investigations of charge dynamics on the nanoscale in other inhomogeneous correlated electron systems. 相似文献
775.
Woo HA Chae HZ Hwang SC Yang KS Kang SW Kim K Rhee SG 《Science (New York, N.Y.)》2003,300(5619):653-656
The active-site cysteine of peroxiredoxins is selectively oxidized to cysteine sulfinic acid during catalysis, which leads to inactivation of peroxidase activity. This oxidation was thought to be irreversible. However, by metabolic labeling of mammalian cells with 35S, we show that the sulfinic form of peroxiredoxin I, produced during the exposure of cells to H2O2, is rapidly reduced to the catalytically active thiol form. The mammalian cells' ability to reduce protein sulfinic acid might serve as a mechanism to repair oxidatively damaged proteins or represent a new type of cyclic modification by which the function of various proteins is regulated. 相似文献
776.
Grigoryan G Kim YH Acharya R Axelrod K Jain RM Willis L Drndic M Kikkawa JM DeGrado WF 《Science (New York, N.Y.)》2011,332(6033):1071-1076
There is a general need for the engineering of protein-like molecules that organize into geometrically specific superstructures on molecular surfaces, directing further functionalization to create richly textured, multilayered assemblies. Here we describe a computational approach whereby the surface properties and symmetry of a targeted surface define the sequence and superstructure of surface-organizing peptides. Computational design proceeds in a series of steps that encode both surface recognition and favorable intersubunit packing interactions. This procedure is exemplified in the design of peptides that assemble into a tubular structure surrounding single-walled carbon nanotubes (SWNTs). The geometrically defined, virus-like coating created by these peptides converts the smooth surfaces of SWNTs into highly textured assemblies with long-scale order, capable of directing the assembly of gold nanoparticles into helical arrays along the SWNT axis. 相似文献
777.
Choi JS Kim JS Byun IS Lee DH Lee MJ Park BH Lee C Yoon D Cheong H Lee KH Son YW Park JY Salmeron M 《Science (New York, N.Y.)》2011,333(6042):607-610
Graphene produced by exfoliation has not been able to provide an ideal graphene with performance comparable to that predicted by theory, and structural and/or electronic defects have been proposed as one cause of reduced performance. We report the observation of domains on exfoliated monolayer graphene that differ by their friction characteristics, as measured by friction force microscopy. Angle-dependent scanning revealed friction anisotropy with a periodicity of 180° on each friction domain. The friction anisotropy decreased as the applied load increased. We propose that the domains arise from ripple distortions that give rise to anisotropic friction in each domain as a result of the anisotropic puckering of the graphene. 相似文献
778.
Morphological abnormalities including extra compound eyes, extra heads, and distally duplicated legs were generated in cricket embryos by treating eggs with single doses of either benz[g]isoquinoline-5,10-dione or benzo[h]quinoline-5,6-dione. Slight structural modifications of the molecules resulted in a loss of teratogenic activity, although embryotoxicity occurred. These potent insect teratogens can be used for analysis of developmental events during embryogenesis. 相似文献
779.
Profiles development of the melt spinning process of poly(trimethylene terephthalate) (PTT) was simulated by a numerical method.
The spinning speed of 3 km/min to 5 km/min was analyzed and the characteristic of PTT spinning process was compared with that
of poly(ethylene terephthalate) (PET). Velocity development of PTT was slower than that of PET. Although PTT’s spinning temperature
was lower than PET’s, the PTT solidified slower because of a smaller super-cooling and the large specific heat capacity. The
diameter profile of PTT decreases gradually in comparison with that of PET. PTT’s strain rate has a broader distribution than
PET’s and its maximum ranged from 541 to 570 s−1 for PET and 136 to 149 s−1 for PTT. PTT’s tensile stress was smaller than PET’s. 相似文献
780.
Hydrogels of semi-interpenetrating polymer networks (semi-IPNs) were prepared by two step reactions. Dimethylaminoethyl methacrylate
(DMAM) and poly(ethylene glycol)-dimethacrylate (PEGDM) were copolymerized to yield hydrogels, and then acrylic acid (AA)
monomer were adsorbed in the hydrogels followed by polymerization of AA to produce semi-IPNs. The swelling behavior of semi-IPNs
depends largely on pH of medium, showing that the degree of swelling of the semi-IPNs exhibits a minimum at pH 6.0. It is
observed that the elastic modulus of semi-IPNs is closely related to its swelling behavior. 相似文献