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131.
JK Harmon SJ Ostro LAM Benner KD Rosema RF Jurgens R Winkler DK Yeomans D Choate R Cormier JD Giorgini DL Mitchell PW Chodas R Rose D Kelley MA Slade ML Thomas 《Science (New York, N.Y.)》1997,278(5345):1921-1924
Radar observations of comet Hyakutake (C/1996 B2) made at the Goldstone Deep Space Communications Complex in California have detected echoes from the nucleus and from large grains in the inner coma. The nucleus of this bright comet was estimated to be only 2 to 3 kilometers in diameter. Models of the coma echo indicate backscatter from porous, centimeter-size grains ejected anisotropically at velocities of tens of meters per second. The radar observations suggest that a comet's activity may be a poor indicator of its size and provide evidence that large grains constitute an important component of the mass loss from a typical active comet. 相似文献
132.
Activation of the HIV-1 LTR by T cell mitogens and the trans-activator protein of HTLV-I 总被引:102,自引:0,他引:102
M Siekevitz S F Josephs M Dukovich N Peffer F Wong-Staal W C Greene 《Science (New York, N.Y.)》1987,238(4833):1575-1578
To investigate the mechanism by which immune activation augments replication of the human immunodeficiency virus type 1 (HIV-1) in infected T cells, four different classes of T cell mitogens were evaluated for their effects on the HIV-1 long terminal repeat (LTR). Phytohemagglutinin (PHA), a mitogenic lectin; phorbol 12-myristic 13-acetate, a tumor promoter; ionomycin, a calcium ionophore; and tat-1, the trans-activator protein from the human T cell leukemia/lymphoma virus type I (HTLV-I) each stimulated the HIV-1 LTR. Studies of deleted forms of the LTR supported a central role in these responses for the HIV-1 enhancer, which alone was sufficient for mitogen inducibility, but also suggested that other 5' positive and negative regulatory elements contribute to the overall magnitude of the response. Synergistic activation of the HIV-1 LTR (up to several thousandfold) was observed with combinations of these mitogens and the HIV-1--derived tat-III protein. Cyclosporin A, an immunosuppressive agent, inhibited PHA-mediated activation of the HIV-1 LTR but was without effect in the presence of other mitogens. Thus, HIV-1 gene expression and replication appear to be regulated, via the HIV-1 LTR, by the same mitogenic signals that induce T cell activation. 相似文献
133.
通常情况下,管道涂敷商在涂敷新涂层之前,都要将管道表面处理到Sa 2.5级或者近白级,但是在施工现场却很难达到这一标准.讨论了旧涂层去除的常规方法、表面处理以及可预见的结果,并讨论了当前在表面处理方面的研究成果以及在涂层涂敷过程中二次生锈的各种影响. 相似文献
134.
135.
Recognition that organic solids possess some of the largest all-optical nonlinearities of all known materials has resulted in an interdisciplinary effort directed at both the basic understanding and exploitation of these effects. Parallel efforts on ionrganic semiconductors have already reached a mature stage whereby the origin of the effects, together with the prospects for device applications, are well known and appreciated. In this article, a unified picture of nonlinear optical phenomena in both classes of materials is presented. The specific implications for organic-based optical devices are discussed. 相似文献
136.
JD Archibald 《Science (New York, N.Y.)》1996,272(5265):1150-1153
Seventeen of eighteen orders of living placental mammals are not known before 65 million years ago. The monophyly of each order is well established, but interrelations have been less certain. A superordinal grouping of up to seven extant orders plus a variety of extinct orders, all included within Ungulata ("hoofed" mammals), can be linked to Late Cretaceous mammals from the 85-million-year-old Bissekty Formation, Uzbekistan (and, less certainly, North America and Europe), thus pushing the origin of this major clade back by 20 million years. Ungulatomorphs are not closely related to primates, rodents, or rabbits. 相似文献
137.
138.
Hess SL Henry RM Leovy CB Ryan JA Tillman JE Chamberlain TE Cole HL Dutton RG Greene GC Simon WE Mitchell JL 《Science (New York, N.Y.)》1976,194(4260):78-81
The results from the meteorology instruments on the Viking 1 lander are presented for the first 20 sols of operation. The daily patterns of temperature, wind, and pressure have been highly consistent during the period. Hence, these have been assembled into 20-sol composites and analyzed harmonically. Maximum temperature was 241.8 degrees K and minimum 187.2 degrees K. The composite wind vector has a mean diurnal magnitude of 2.4 meters per second with prevailing wind from the south and counterclockwise diurnal rotation. Pressure exhibits diurnal and semidiurnal oscillations. The diurnal is ascribed to a combination of effects, and the semidiurnal appears to be the solar semidiurnal tide. Similarities to Earth are discussed. A major finding is a continual secular decrease in diurnal mean pressure. This is ascribed to carbon dioxide deposition at the south polar cap. 相似文献
139.
Fauci AS Johnston MI Dieffenbach CW Burton DR Hammer SM Hoxie JA Martin M Overbaugh J Watkins DI Mahmoud A Greene WC 《Science (New York, N.Y.)》2008,321(5888):530-532
The need to broaden research directed at answering fundamental questions in HIV vaccine discovery through laboratory, nonhuman primate (NHP), and clinical research has recently been emphasized. In addition, the importance of attracting and retaining young researchers, developing better NHP models, and more closely linking NHP and clinical research is being stressed. In an era of a level budget for biomedical research at the U.S. National Institutes of Health (NIH), HIV/AIDS vaccine research efforts will need to be carefully prioritized such that resources to energize HIV vaccine discovery can be identified. This article summarizes progress and challenges in HIV vaccine research, the priorities arising from a recent summit at NIAID, and the actions needed, some already under way, to address those priorities. 相似文献
140.