Randomized controlled trial of the efficacy of cyclosporine in the treatment of atopic dermatitis in dogs

OBJECTIVE: To evaluate efficacy of cyclosporine A, administered at either of 2 dosages, in dogs with atopic dermatitis (AD). DESIGN: Multicenter randomized controlled trial. ANIMALS: 91 dogs with AD. PROCEDURE: Dogs were assigned to receive placebo (30 dogs), cyclosporine at a low dosage (2.5 mg/kg [1.1 mg/lb], PO, q 24 h for 6 weeks; 30 dogs), or cyclosporine at a high dosage (5.0 mg/kg [2.3 mg/lb], PO, q 24 h for 6 weeks; 31 dogs). RESULTS: After 6 weeks, mean percentage reductions, compared with baseline scores, in scores of lesion severity were 34, 41, and 67% for dogs treated with the placebo, cyclosporine at the low dosage, and cyclosporine at the high dosage, respectively. Similarly, mean percentage reductions in pruritus scores were 15, 31, and 45%, respectively. Percentage reductions in skin lesion and pruritus scores were significantly higher for dogs given cyclosporine at the high dosage than for dogs given the placebo. Treatment efficacy was significantly associated with whether dogs had a history of seasonal AD. Percentage reductions in skin lesion and pruritus scores were high for dogs treated with cyclosporine at the highest dosage that had a history of nonseasonal AD. Dogs in all groups with seasonal AD improved during the study period. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that oral administration of cyclosporine at a dosage of 5.0 mg/kg once daily is effective in reducing severity of pruritus and skin lesions in dogs with AD, especially those with nonseasonal disease.     

Growth fundamentalism in dying rural towns:Implications for rural development practitioners

In our paper we will try to connect the dynamics of community decline to individual responses. We will operate on two levels of reality. At the first level we will discuss the circumstances surrounding the recent decline of small communities in North Dakota. At the second level we will discuss how this decline affects small town residents' attitudes toward economic development. In the first level analysis we examine the thesis that the natural environment of community growth is economic exploitation; therefore, the decline of resource-based communities is natural and inevitable. We discuss the circumstances surrounding the recent decline of small communities in North Dakota. At the second level analysis, we operate at the level at which life circumstances and environments are shaped by political-economic institutions that in turn shape the behavior and mentality of communities, families, and individuals. We hypothesize that residents of declining small towns deny their powerlessness and adapt to their situation through intense dedication to economic growth. We develop a series of hypotheses to test this thesis using data from the North Dakota Rural Life Poll. In our conclusion, we discuss implications for rural development practitioners working in declining small towns where this intense dedication to economic development in prevalent.Dr. Stofferahn is an assistant professor in the Department of Sociology and director of the Social Science Research Institute at the University of North Dakota. He received his Ph.D. and M.S. in rural sociology from Iowa State University. Prior to coming to the University of North Dakota, Dr. Stofferahn was employed by the North Dakota Economic Development Commission. Mr. Fontaine received his M.S. in sociology from the University of North Dakota and is presently employed as the assistant director of the Social Science Research Institute. Douglas McDonald, Mike Spletto and Holly Jeanotte are graduate students in the Department of Sociology at the University of North Dakota. This paper originally was written as a class project in a graduate seminar in rural development.     

Amino Acid contents in raw materials can be precisely analyzed in a global network of near-infrared spectrometers: collaborative trials prove the positive effects of instrument standardization and repeatability files

Four international ring trials for NIRS amino acid analysis of feed raw materials have demonstrated for the first time that the calibrations developed by Degussa allow reliable and precise predictions of essential amino acids in up to 44 NIR spectrometers. Different standardization techniques were compared, and the effectiveness of using spectra of the host instruments as repeatability files was studied. The ultimately achieved reproducibility of 2-3% CV for almost all analyses in the network is considerably better than ring trial results for wet chemical amino acid analysis.     

Application of aquariological techniques to an intensive fish-rearing process using recycled, warmed water for the production of rainbow trout fry, Oncorhynchus mykiss

Since 1991, the Laboratoire de Biologie Appliquée has been developing a new, intensive fish-rearing process. Based on simple aquariological techniques used at the Nancy Aquarium Tropical, the process involves recycled, warmed (18–20°C) water, and autonomous modular units both technically simple and small in size. Among its applications is the production of rainbow trout fry, Oncorhynchus mykiss. At present, from an initial batch of 100 000 eye-stage embryonated eggs, it allows 85 000 fry of 0·8-1 g to be produced in 60 days for a water consumption of less than 10 m³.     

Reproductive Performance of Rabbit Does Artificially Inseminated via Intravaginal Administration of [des-Gly 10, d-Ala6]-LHRH Ethylamide as Ovulation Inductor

This study was aimed to evaluate the reproductive performance of rabbit does artificially inseminated (AI) with a GnRH analogue [des‐Gly10, d ‐Ala6]‐LHRH. ethylamide to induce ovulation by intravaginal administration, delivered in the seminal dose. In a preliminary experiment, 39 does were divided into three groups (n = 13) that, at the time of AI, received the following ovulation induction treatments: (i) control group: 20 μg of gonadorelin administered intramuscularly; (ii) 25 μg of the GnRH analogue added to the seminal dose; (iii) 30 μg of the GnRH analogue added to the seminal dose. Fertility did not differ between the three groups (control: 80.6%, group 2: 82.8%, group 3: 73.3%). In a second experiment, a large‐scale field trial was conducted to test the use of 25 μg of the GnRH analogue [des‐Gly10, d ‐Ala6]‐LHRH ethylamide delivered in the seminal dose (n = 270) against 20 μg of gonadorelin administered intramuscularly. Fertility was higher (p < 0.05) when ovulation was induced by intravaginal administration of the GnRH agonist (91.1% vs 85.6%). Prolificacy or mortality at birth was never affected by the ovulation induction treatments. In a third experiment, two groups of does [control group (n = 39): ovulation was induced using 20 μg of gonadorelin administered intramuscularly; treatment group (n = 40): ovulation was induced using 25 μg of [(des‐Gly10, d ‐Ala6)‐LHRH ethylamide added to the seminal dose] were inseminated at 42‐day intervals for five successive AI cycles, to test the response to the GnRH agonist after repeated intravaginal administration to the same animals. Fertility and prolificacy were not influenced by the ovulation induction treatment neither there was an interaction between treatment and parity. The last experiment was aimed to determine whether it could be possible to add the GnRH agonist to the semen in the AI Center, just after semen collection and dilution, or it would have to be added in the farm, immediately before AI. Kindling rates did not significantly differ when ovulation was induced by intramuscular injection of gonadorelin (84.5%) or when the GnRH agonist was added to the seminal dose just at the moment (93.8 %) or 24 h before AI (90.4 %), but it was significantly lower when the hormone was added to the semen 32 h before AI (76.3 %). Prolificacy, however, was not influenced by the ovulation induction treatment.