Relationship between apolipoprotein E gene polymorphism and sporadic Alzheimer's disease

AIM: To evaluate the association between apolipoprotein E(apoE) gene polymorphism and sporadic Alzheimer's disease (AD). METHOD: A case-control study was undertaken detecting the polymorphism of apoE by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP).RESULTS:(1)The frequencies of 3/4 genotype and 4 al ele in AD were significant ly higher than that in age-matched controls(P<0.05).(2)The frequency of G/G genotype for apoE IE1 in AD was significantly higher than that in age-mat ched control(P<0.05).(3)The apoE 4 al ele was associated with a tripling of the risk for AD compared with no 4 allele(odd ratio 2.932, 95%CI 1.379~6.226);Homozygosity of the G allele in IE1 was associated with adoubling of the risk for AD compared with the G/C and C/C genotypes(odd rat io 2.223, 95%CI 1.075~4.599).However, the IE1 G al ele is also closely associated with apoE 4.When the sample was split on the basis of apo Egenotype, the associat ion between IE1 G/G genotype and AD was no longer statistically significant.CONCLUSION: ApoE ε4 was a risk factor of AD, and the apparent association between IE1 G/G and AD is a consequence of the association between the ε4 and IE1 G/G genotype.     

基于代谢组学技术的无机砷对三疣梭子蟹鳃组织的毒性作用机制研究

通过非靶向代谢组学方法对比分析暴露于0.3 mg/L三价砷(As3+)、0.3 mg/L五价砷(As5+)环境中96 h的雌性成体三疣梭子蟹(Portunus trituberculatus)代谢物组成及含量的变化,探究As3+、As5+对三疣梭子蟹鳃组织毒性相关分子机制.结果 发现,经0.3 mg/L As3+暴露共...     

超级杂交稻国稻1号农艺性状研究

对超级杂交稻国稻1号和杂交稻汕优63的株型特征以及农艺性状进行了比较分析,结果表明:国稻1号的单产之所以显著高于汕优63的,主要因为前者分蘖多且分蘖快,单位面积有效穗数和每穗总粒数多,而且结实率高。     

中国农业装备产业发展战略研究

该文深入分析了中国农业装备产业发展现状与态势、发展中存在的问题与制约因素,提出振兴中国农业装备产业要实施自主创新战略、现代制造技术改造提升战略、组织结构优化战略、品牌培育战略以及市场拓展战略5大具体战略,以实现2010年农业装备制造业工业总产值翻一番,装备技术自主创新能力显著增强;2020年农业装备工业总值将在2010年基础上再提高50％,步入世界农业装备制造强国行列的阶段战略目标。探讨了中国农业装备科技创新体系建设的重点在于强化国家农业装备工程技术研究中心建设、打造大型农业装备制造企业、推进中小企业间合作创新,以增强共性技术研发能力、逐步培育农业装备产业创新主体和构建农业装备技术集成与推广服务平台。最后提出了完善农业装备科技创新机制的政策建议,重点在于建立新型农业装备科技创新运行机制,整合创新资源引导建立产学研合作创新的长效激励机制,建立多元化农业装备创新资金投入机制。     

大学办学特色的形成与图书馆的作用

论述了大学办学特色的内涵与形成,分析了我国大学办学特色的现状,探讨了图书馆在大学办学特色形成中的作用。     

《图书情报工作》办刊理念探讨

基于相关统计资料,探讨了《图书情报工作》在功能定位、栏目设置、作者队伍、编辑质量、学术影响以及社会效益和经济效益等方面的办刊理念,并就该刊今后的发展方向提出了建议。     

苹果浓缩汁二次混浊物的形态分析

通过苹果浓缩汁二次混浊物的形态分析以及浊度测定,初步确定混浊物的化学成分,为果汁生产、贮存中混浊的控制提供依据。将二次混浊果汁和后混浊果汁经乙酸双氧铀负染,观察其在透射式电镜下的形态并测定其浊度。结果表明：苹果浓缩汁经-18℃,冷冻8～10h处理后,苹果浓缩汁混浊减轻;再煮沸冷冻的果汁,混浊增加;二次混浊苹果浓缩汁形成的颗粒经乙酸双氧铀负染在透射式电镜下有蛋白质球状颗粒和链状的多酚类颗粒,或自身聚合或相互聚合形成大的颗粒;贮藏6个月的苹果浓缩汁后混浊比二次混浊严重。初步确定苹果浓缩汁的二次混浊物主要是蛋白质和酚类以及两者自身或相互聚合的产物。     

Progress in Isoindolone Alkaloid Derivatives from Marine Microorganism: Pharmacology,Preparation, and Mechanism

Compound 1 (SMTP-7, also FGFC1), an isoindolone alkaloid from marine fungi Starchbotrys longispora FG216 and fungi Stachybotrys microspora IFO 30018, possessed diverse bioactivities such as thrombolysis, anti-inflammatory and anti-oxidative properties, and so on. It may be widely used for the treatment of various diseases, including cerebral infarction, stroke, ischemia/reperfusion damage, acute kidney injury, etc. Especially in cerebral infarction, compound 1 could reduce hemorrhagic transformation along with thrombolytic therapy, as the traditional therapies are accompanied with bleeding risks. In the latest studies, compound 1 selectively inhibited the growth of NSCLC cells with EGFR mutation, thus demonstrating its excellent anti-cancer activity. Herein, we summarized pharmacological activities, preparation of staplabin congeners—especially compound 1—and the mechanism of compound 1, with potential therapeutic applications.     

改进微波装置辅助提取猕猴桃根三萜类化合物的研究

应用单因素试验、析因试验和响应面分析法等统计学方法,对自行设计的可以同时控制温度的微波装置辅助提取美味猕猴桃根中具有保肝作用的三萜类化合物的工艺进行了深入研究。试验结果表明：在微波功率一定的情况下,乙醇浓度、提取温度和提取时间的影响最显著,优化得到最佳微波辅助提取工艺参数为乙醇浓度63%,温度47℃,时间为30 min,一次提取率可达85.13%。经验证试验证明,该方法是一种实用的提取方法。     

基于GBOM的家电产品配置管理

目前,家电产品种类繁多,管理困难,人工管理物料效率低、准确度差,导致产品成本高,现有的管理模型对于家电产品还不太适应。提出了基于GBOM的产品配置管理模式解决家电企业物料管理中的问题,从而提高生产效率,降低管理成本。