Stress wavelet properties are inherently involved in the process of the drop-shatter method of assessment on soil structural characteristics. The analogies between wavelet analysis and the drop-shatter process are based on two factors: scale and resolution. By carefully following the requirements of wavelet analysis, a standard procedure of soil fragmentation and sieving is described. Following this procedure, a set of equations can be derived from which surface contacting energy between soil aggregates of a specific scale can be calculated. The resultant values in fact mirror the multi-resolutions of wavelets.
Natural soil clods as well as artificial structured soil cores were used for fragmentation. Though the experiment can do well on natural soil clods, and it is precise enough in predicting structural state of a sub-dimensional clods of 8 mm, its use on artificial soil cores produced a set of data that was quite chaotic. The unique behavior experienced in the process of fragmentation of artificial soil structure indicates that there is no distinct stage between mother soil clods (cores) and its constituent primary particles. Such a state should result from an excessively large impact energy (too low a resolution in the wavelet analysis) for each drop stroke impact.
With an ultimate goal for soil process simulation, the construction of the experiment for artificial structured soil core preparation brings the traditional methods of sample preparation a step forward further by creating an environment much nearer to the field conditions experienced in natural soils. Still, extensive refinements are needed, especially for the mode of water application, cycle and intensity of management. 相似文献
Phenylahistin is a naturally occurring marine product with a diketopiperazine structure that can bind to the colchicine site of microtubulin as a possible anticancer agent. To develop more potent microtubule inhibitors, novel phenylahistin derivatives were designed and synthesized based on the co-crystal complexes of phenylahistin derivatives and microtubulin. We established a focused library of imidazole-type molecules for the introduction of different groups to the C-ring and A-ring of phenylahistin. Structure–activity relationship studies indicated that appropriate hydrocarbon substituents and unsaturated alkenyl substituents at the 1-position of the imidazole group are important for improving the activity of such compounds. In addition, this study found that propylamine groups could maintain the activity of these compounds, as exemplified by compound 16d (IC50 = 5.38 nM, NCI-H460). Compound 15p (IC50 = 1.03 nM, NCI-H460) with an allyl group exhibited potent cytotoxic activity at the nanomolar level against human lung cancer cell lines. Immunofluorescence assay indicated that compound 15p could efficiently inhibited microtubule polymerization and induced a high expression of caspase-3. 15p also displayed good pharmacokinetic characteristics in vitro. Additionally, the growth of H22 transplanted tumors was significantly inhibited in BALB/c mice when 15p alone was administered at 4 mg/kg, and the tumor inhibition rate was as much as 65%. Importantly, the continuous administration of 15p resulted in a lower toxicity than that of docetaxel (10 mg/kg) and cyclophosphamide (20 mg/kg). Overall, the novel allyl-imidazole-diketopiperazine-type derivatives could be considered safe and effective potential agents for cancer treatment. 相似文献