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Motor cortex output is capable of considerable reorganization, which involves modulation of excitability within the cortex. Does such reorganization also involve changes beyond the cortex, at the level of throughput from single motor cortex neurons to muscle activity? We examined such throughput during a paradigm that provided incentive for enhancing functional connectivity from motor cortex neurons to muscles. Short-latency throughput from a recorded neuron to muscle activity not present during some behavioral epochs often appeared during others. Such changes in throughput could not always be attributed to a higher neuron firing rate, to more ongoing muscle activity, or to neuronal synchronization, indicating that reorganization of motor cortex output may involve rapid changes in functional connectivity from single motor cortex neurons to alpha-motoneuron pools. 相似文献
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Diffusion of radon and thoron from the Ilunar surface provides a mechanism for production of a radioactive surface layer on the moon. If the radon and thoron flux from the lunar surface is equal to that measured at the earth's surface, the equilibrium activity of this surface layet is estimated as approximately 1 microcurie per square meter, due to radon and its decay products. This activity consists of alpha particles and gamnmna rays at well-defined energies and of beta rays. 相似文献
55.
Katsanis N Ansley SJ Badano JL Eichers ER Lewis RA Hoskins BE Scambler PJ Davidson WS Beales PL Lupski JR 《Science (New York, N.Y.)》2001,293(5538):2256-2259
Bardet-Biedl syndrome (BBS) is a genetically heterogeneous disorder characterized by multiple clinical features that include pigmentary retinal dystrophy, polydactyly, obesity, developmental delay, and renal defects. BBS is considered an autosomal recessive disorder, and recent positional cloning efforts have identified two BBS genes (BBS2 and BBS6). We screened our cohort of 163 BBS families for mutations in both BBS2 and BBS6 and report the presence of three mutant alleles in affected individuals in four pedigrees. In addition, we detected unaffected individuals in two pedigrees who carry two BBS2 mutations but not a BBS6 mutation. We therefore propose that BBS may not be a single-gene recessive disease but a complex trait requiring three mutant alleles to manifest the phenotype. This triallelic model of disease transmission may be important in the study of both Mendelian and multifactorial disorders. 相似文献
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Norell MA Clark JM Demberelyin D Rhinchen B Chiappe LM Davidson AR McKenna MC Altangerel P Novacek MJ 《Science (New York, N.Y.)》1994,266(5186):779-782
An embryonic skeleton of a nonavian theropod dinosaur was found preserved in an egg from Upper Cretaceous rocks in the Gobi Desert of Mongolia. Cranial features identify the embryo as a member of Oviraptoridae. Two embryo-sized skulls of dromaeosaurids, similar to that of Velociraptor, were also recovered in the nest. The eggshell microstructure is similar to that of ratite birds and is of a type common in the Djadokhta Formation at the Flaming Cliffs (Bayn Dzak). Discovery of a nest of such eggs at the Flaming Cliffs in 1923, beneath the Oviraptor philoceratops holotype, suggests that this dinosaur may have been a brooding adult. 相似文献
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More and more scientists and engineers are becoming interested in using supercomputers. Earlier barriers to using these machines are disappearing as software for their use improves. Meanwhile, new parallel supercomputer architectures are emerging that may provide rapid growth in performance. These systems may use a large number of processors with an intricate memory system that is both parallel and hierarchical; they will require even more advanced software. Compilers that restructure user programs to exploit the machine organization seem to be essential. A wide range of algorithms and applications is being developed in an effort to provide high parallel processing performance in many fields. The Cedar supercomputer, presently operating with eight processors in parallel, uses advanced system and applications software developed at the University of Illinois during the past 12 years. This software should allow the number of processors in Cedar to be doubled annually, providing rapid performance advances in the next decade. 相似文献
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The extraordinary abundance of ants in tropical rainforest canopies has led to speculation that numerous arboreal ant taxa feed principally as "herbivores" of plant and insect exudates. Based on nitrogen (N) isotope ratios of plants, known herbivores, arthropod predators, and ants from Amazonia and Borneo, we find that many arboreal ant species obtain little N through predation and scavenging. Microsymbionts of ants and their hemipteran trophobionts might play key roles in the nutrition of taxa specializing on N-poor exudates. For plants, the combined costs of biotic defenses and herbivory by ants and tended Hemiptera are substantial, and forest losses to insect herbivores vastly exceed current estimates. 相似文献