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排序方式: 共有698条查询结果,搜索用时 15 毫秒
1.
In conscious pigs the influence of intravenous infusion of live E. coli (7×108/kg), of the equivalent amount of endotoxin (20 g/kg) or of a high dose of endotoxin (2.5 mg/kg) on the hemodynamic, clinical and pathological parameters and on survival rate was studied. E. coli and endotoxin infusion resulted in pulmonary hypertension, systemic arterial hypotension, a decrease in cardiac output and an increase in heart rate. Clinical signs were characterized by respiratory and nervous disturbances, whereas necropsy revealed hemorrhages and edema in several organs. Although these findings were similar in the three groups, a marked difference in lethality was observed. Infusion of E. coli or of the high dose of endotoxin resulted in a significant mortality, whereas all pigs survived the infusion of the low dose of endotoxin. This suggests that the lethal pathophysiological mechanisms may only become activated when a sufficient amount of endotoxin is released into the circulation. 相似文献
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Anti-erythrocytic immunoglobulins in serum and colostrum of 124 anaplasmosis-vaccinated cows were detected with a saline agglutination test. Positive results were correlated with the occurrence of neonatal isohemolytic anemia (NIA) in calves and were used to predict the occurrence of NIA. The disease was prevented by withholding colostrum from calves with a high potential for NIA. 相似文献
5.
Worster AA Lillich JD Cox JH Rush BR 《Journal of the American Veterinary Medical Association》2000,216(11):1795-8, 1760
A 9-year-old pregnant mare was referred for evaluation of a nonhealing wound of 8 weeks' duration on the lateral aspect of the left forelimb. A soft tissue mass encircled the proximal two thirds of the metacarpus; radiography revealed a moderate periosteal reaction affecting metacarpal bone i.v. Histologic and immunohistochemical examinations revealed eosinophilic granulomatous inflammation and Pythium sp in the soft tissues. The mare was treated for 12 days with antimicrobials, medicated wound dressings, debridement, and i.v. administration of sodium iodide; radiography revealed progression of the bone lesions. The mare was treated by regional arterial perfusion with miconazole and excision of affected soft tissues and the distal two thirds of metacarpal bone i.v. The mare recovered without complications and gave birth to a healthy foal. Regional perfusion of antifungal agents provides high concentrations in soft and osseous tissues and permits use of low dosages of agents administered by other routes, which reduces cost, adverse effects, and teratogenic effects. 相似文献
6.
Clinical and in vitro efficacy of amoxicillin against bacteria associated with feline skin wounds and abscesses 总被引:1,自引:0,他引:1
Roy J Messier S Labrecque O Cox WR 《The Canadian veterinary journal. La revue veterinaire canadienne》2007,48(6):607-611
A clinical trial involving 122 cats with infected skin wounds or abscesses presented to 10 veterinary clinics was conducted to evaluate the efficacy of 2 oral amoxicillin drug products (a paste and a suspension). A 2nd objective of the study was to identify bacteria involved in such infections and verify their in vitro sensitivity to amoxicillin. Samples of wound exudate were harvested at the time of presentation and submitted for aerobic and anaerobic culture. The sensitivity to amoxicillin of isolates thought to be infecting agents was tested, using a standard minimum inhibitory concentration method. Pasteuralla multocida and obligate anaerobes of the genera Prevotella, Fusobacterium, and Porphyromonas were the most frequently isolated pathogens. Overall, their in vitro susceptibility to amoxicillin was very good. Both drug products were clinically efficacious with a global success rate of 95.1% for cats administered oral amoxicillin at 11-22 mg/kg bodyweight (mean 13.8 mg/kg bodyweight) twice daily for 7 to 10 days. 相似文献
7.
全球禽肉生产和贸易中的沙门菌风险评估与控制 总被引:1,自引:0,他引:1
G.Mead A.M.Lammerding N.Cox M.P.Doyle F.Humbert A.Kulikocskiy A.Panin V.P.do Nascimento M.Wierup 《中国家禽》2011,33(5)
1 禽源沙门菌对公共卫生的影响
在许多国家,沙门菌仍是引发食源性肠道疾病的主要原因.沙门菌通常存在于家畜、家禽中,也可在啮齿类、爬行类和鸟类等野生动物中发现.当农场的禽群感染沙门菌后,通常会有一部分家禽的消化道中携带沙门菌,但并无症状.随后,沙门菌可能会通过粪便污染感染动物屠体. 相似文献
8.
Carrie A. Davis Reza Seddighi Sherry K. Cox Xiaocun Sun Christine M. Egger Thomas J. Doherty 《Veterinary anaesthesia and analgesia》2017,44(4):727-737
Objective
To determine the effect of fentanyl on the induction dose of propofol and minimum infusion rate required to prevent movement in response to noxious stimulation (MIRNM) in dogs.Study design
Crossover experimental design.Animals
Six healthy, adult intact male Beagle dogs, mean ± standard deviation 12.6 ± 0.4 kg.Methods
Dogs were administered 0.9% saline (treatment P), fentanyl (5 μg kg?1) (treatment PLDF) or fentanyl (10 μg kg?1) (treatment PHDF) intravenously over 5 minutes. Five minutes later, anesthesia was induced with propofol (2 mg kg?1, followed by 1 mg kg?1 every 15 seconds to achieve intubation) and maintained for 90 minutes by constant rate infusions (CRIs) of propofol alone or with fentanyl: P, propofol (0.5 mg kg?1 minute?1); PLDF, propofol (0.35 mg kg?1 minute?1) and fentanyl (0.1 μg kg?1 minute?1); PHDF, propofol (0.3 mg kg?1 minute?1) and fentanyl (0.2 μg kg?1 minute?1). Propofol CRI was increased or decreased based on the response to stimulation (50 V, 50 Hz, 10 mA), with 20 minutes between adjustments. Data were analyzed using a mixed-model anova and presented as mean ± standard error.Results
ropofol induction doses were 6.16 ± 0.31, 3.67 ± 0.21 and 3.33 ± 0.42 mg kg?1 for P, PLDF and PHDF, respectively. Doses for PLDF and PHDF were significantly decreased from P (p < 0.05) but not different between treatments. Propofol MIRNM was 0.60 ± 0.04, 0.29 ± 0.02 and 0.22 ± 0.02 mg kg?1 minute?1 for P, PLDF and PHDF, respectively. MIRNM in PLDF and PHDF was significantly decreased from P. MIRNM in PLDF and PHDF were not different, but their respective percent decreases of 51 ± 3 and 63 ± 2% differed (p = 0.035).Conclusions and clinical relevance
Fentanyl, at the doses studied, caused statistically significant and clinically important decreases in the propofol induction dose and MIRNM. 相似文献9.
Cox S Martin-Jimenez T van Amstel S Doherty T 《Journal of veterinary pharmacology and therapeutics》2011,34(3):259-264
The purpose of this study was to determine the pharmacokinetics of tramadol and its metabolite M1 after intravenous and intramuscular administration to llamas. Tramadol, a centrally acting analgesic whose efficacy is a result of complex interactions between opiate, adrenergic and serotonin receptor systems, has been used clinically to treat moderate to severe pain in humans. The pharmacokinetic parameters of tramadol and M1 in plasma were examined following intravenous and intramuscular administration to six healthy male llamas. Tramadol half-life, volume of distribution at steady-state and clearance after intravenous administration were 2.12 ± 0.37 h, 4.02 ± 1.16 L/kg and 1728.73 ± 152.82 mL/h/kg, respectively. The bioavailability was 110 ± 21% and half-life 2.54 ± 0.31 h following intramuscular administration of tramadol. M1 had a half-life of 10.40 ± 2.90 h and 7.71 ± 0.54 h following intravenous and intramuscular administration of tramadol. 相似文献