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11.
Two field trials to reduce the prevalence of Echinococcus multilocularis in foxes have been conducted in recent years. Although both trials reduced prevalence considerably, they failed to eradicate the parasite in the study region. Following the control trial in northern Germany, prevalence recovered unexpectedly and rapidly, reaching pre-control levels five quarters (15 months) after the end of control. To understand the internal dynamics of the parasite-host system's reaction to control, we developed a spatially explicit simulation model, Echi. The simulation model incorporates the information available concerning fox tapeworm population dynamics.Using epidemiological parameters to adjust pre-control prevalence, the model predicts the temporal evolution of the prevalence of E. multilocularis in controlled foxes without departing from the range of uncertainty of the field data. However, the model does not predict the rapid pre-control recovery observed in the field trial.The deviation of the model's prediction from field data indicates the involvement of processes not yet taken into account. We modified the model step by step to mimic processes with the potential to cause the rapid post-control recovery of the prevalence of E. multilocularis in foxes.Neither the longevity of tapeworm eggs nor the migratory behaviour of foxes showed any influence on the post-control reaction of the parasite-host system. However, landscape structures leading to a heterogeneous distribution of infected foxes have the potential to alter the system's reaction to control. If infected foxes are concentrated in multiple clusters in the landscape, the model prediction tallied with the range of uncertainty of the field data. Such spatial distribution of infected foxes may be caused by differential abiotic conditions influencing the survival of tapeworm eggs.The model was found to comply best with field data if the foxes acquire partial immunity by being exposed to the fox tapeworm.Both hypotheses explaining the rapid post-control recovery of the prevalence of E. multilocularis observed in the fox population were supported by field data.Both hypotheses have far-reaching consequences for future control trials. The spatial aggregation of infected foxes would enable control efforts to be concentrated on these highly infected areas. However, the acquisition of immunity acts as a buffer to control, necessitating intensified control measures. 相似文献
12.
Florian M.W. Grundler Miroslaw Sobczak Wladyslaw Golinowski 《European journal of plant pathology / European Foundation for Plant Pathology》1998,104(6):545-551
The induction and differentiation of feeding structures (syncytia) of the cyst nematode Heterodera schachtii in roots of Arabidopsis thaliana is accompanied by drastic cellular modifications. We investigated the formation of cell wall openings which occurred during syncytium differentiation. At the beginning of syncytium induction, a callose-like layer was deposited inside of the wall of the initial syncytial cell (ISC). First wall dissolutions developed by gradual widening of plasmodesmata between the ISC and neighbouring cells. As a general thickening of syncytial cell walls blocked existing plasmodesmata, other large openings were formed by enzymatic dissolution of intact walls by putative cellulase activity. 相似文献
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DISPERSAL PATTERN OF INJECTATE FOLLOWING CT‐GUIDED PERINEURAL INFILTRATION IN THE CANINE THORACOLUMBAR SPINE: A CADAVER STUDY 下载免费PDF全文
Sibylle Kneissl Sabine Breit Florian Willmitzer Johann Thalhammer Sabine Dengg 《Veterinary radiology & ultrasound》2015,56(2):212-219
An increasing proportion of canine patients are presented with chronic thoracolumbar back pain and without compressive spinal lesions. In humans, spinal perineural infiltrations have been reported to have a favorable effect on pain control. The purpose of this prospective cadaver study was to describe the dispersal pattern of injectate following CT‐guided spinal perineural infiltration in the canine thoracolumbar region. Seven fresh canine cadavers were first scanned using multislice CT and then CT‐guided spinal perineural infiltration was performed at 42 sites from T13/L1 to L6/L7. The injectate for each site was a mixture of new methylene blue and iodinated contrast medium. Immediately following CT‐guided injection, cadavers were frozen, cut, and dissected macro‐ and mesoscopically (using a magnifying glass) to identify anatomic structures that were infiltrated. In the majority of sites (64.3%), complete epidural and hypaxial staining of spinal nerve components (including the spinal ganglion, trunk, and ventral branch) was successfully achieved. However, no (11.9%) or unpredictable staining (9.5%) of nervous tissue occurred in some sites despite careful CT guidance and the application of relatively large volumes of injectate. Optimal results were achieved when the needle tip was positioned periforaminally ventral to the cranial contour of the cranial articular process. Findings from this ex vivo study indicated that CT‐guided spinal perineural infiltration is feasible for testing in the canine thoracolumbar region and that successful nerve tissue infiltration would likely occur in the majority of sites. Future in vivo studies are needed to determine the safety and efficacy of this technique. 相似文献
14.
Influence of ketamine or xylazine supplementation on isoflurane anaesthetized horses‐ a controlled clinical trial 下载免费PDF全文
Nina Pöppel Klaus Hopster Florian Geburek Sabine Kästner 《Veterinary anaesthesia and analgesia》2015,42(1):30-38
ObjectivesTo determine the influence of ketamine or xylazine constant rate infusions on isoflurane requirements, cardiovascular parameters and quality of anaesthesia in horses undergoing elective surgery.Study designProspective, matched paired clinical trial.AnimalsFifty four adult Warmblood horses.MethodsAfter premedication with acepromazine, xylazine and butorphanol, anaesthesia was induced with ketamine-midazolam and maintained with isoflurane alone (I), isoflurane with either 1 mg kg−1 hour−1 ketamine (IK) or same dose of xylazine (IX). End tidal concentration of isoflurane (Fe’Iso) was adjusted by the same anaesthetist in all horses according to a scoring system. Dobutamine was infused to maintain mean arterial pressure (MAP) =70 mmHg. Arterial blood gases, heart rate (HR), respiratory rate, MAP and cardiac output (lithium dilution) were measured. Groups I and IK received xylazine before recovery. Recovery quality was scored.ResultsMean ± SD averaged Fe’Iso (volume%) was significantly lower in IX (0.95 ± 0.07) and IK (0.97 ± 0.08) than in I (1.16 ± 0.13). In group IX, HR was significantly lower and averaged MAP (90 ± 13 mmHg) significantly higher than in groups I (71 ± 7 mmHg) and IK (76 ± 7 mm Hg). Differences in other cardiopulmonary variables did not reach statistical significance. All horses recovered well with best score in group IX.ConclusionsBoth CRIs of xylazine and of ketamine resulted in pronounced reduction of isoflurane requirements and blood pressure support based on routinely monitored parameters. Cardiac output appeared well maintained in all three protocols, but lithium dilution induced errors mean the results are untrustworthy. The work requires repetition with another mode of measurement of cardiac output.Clinical relevanceAll three protocols provided good clinical anaesthesia with clinically acceptable cardiovascular effects. 相似文献
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16.
Opportunities and Challenges of Carbon Footprint,Climate or CO2 Labelling for Horticultural Products
The number of fruits on the German and European markets with a carbon label is on the increase. This contribution reviews the existing carbon labels by evaluating, categorising and giving background information to provide guidance for labelling home-grown horticultural produce. The existing labels worldwide were classified in 10 categories: (1) CO2 value; (2) Colour code (with or without CO2 value); (3) CO2 reduction (Carbon Trust, Tesco’s, UK) or conversion labels; (4) Climatop for Migros, Switzerland (temporal label for the best product within a product category, e.g., banana, rice, salt); (5) Airfreight labels, e.g., Marks & Spencer’s UK (without further information); (6) ‘Climate, carbon offset or CO2-neutral’, e.g., NewTree, (only when using gold standard CO2 emission certificates); (7) unaccounted CO2 compensation measures (such as planting young trees: ‘CO2 pineapple’ in Costa Rica); (8) Sustainability labels (ProPlanet, REWE), (9) sustainability reports (printed or online) and (10) QR-Code on the shelf or product to access web-based information. The ‘Pros and Cons’ of the climate labels are compared with respect to the seasonal fruit and vegetables often sold on the markets as lose items and the stakeholder interest. Labelling approaches 4, 8, 9 and 10 appeared suitable for seasonal fruits and vegetables based on criteria such as transparency, clarity, objectivity and integration in the sustainability context. Overall, it is difficult to use labels with a CO2 value for horticultural products, because (a) the consumer may find it difficult to judge and memorise numeric values, particularly if expressed on different units (e.g. packet size, 1 l, 100 g) and (b) because of the big variation between the farm production systems and the variability between the year to year weather and (c) the consumer may find shopping with a seasonal crop calendar and country of origin label a better choice. 相似文献
17.
18.
Oberstrass FC Auweter SD Erat M Hargous Y Henning A Wenter P Reymond L Amir-Ahmady B Pitsch S Black DL Allain FH 《Science (New York, N.Y.)》2005,309(5743):2054-2057
The polypyrimidine tract binding protein (PTB) is a 58-kilodalton RNA binding protein involved in multiple aspects of messenger RNA metabolism, including the repression of alternative exons. We have determined the solution structures of the four RNA binding domains (RBDs) of PTB, each bound to a CUCUCU oligonucleotide. Each RBD binds RNA with a different binding specificity. RBD3 and RBD4 interact, resulting in an antiparallel orientation of their bound RNAs. Thus, PTB will induce RNA looping when bound to two separated pyrimidine tracts within the same RNA. This leads to structural models for how PTB functions as an alternative-splicing repressor. 相似文献
19.
Schiestl FP Peakall R Mant JG Ibarra F Schulz C Franke S Francke W 《Science (New York, N.Y.)》2003,302(5644):437-438
The "sexually deceptive" orchid Chiloglottis trapeziformis attracts males of its pollinator species, the thynnine wasp Neozeleboria cryptoides, by emitting a unique volatile compound, 2-ethyl-5-propylcyclohexan-1,3-dione, which is also produced by female wasps as a male-attracting sex pheromone. 相似文献
20.
Grimm V Revilla E Berger U Jeltsch F Mooij WM Railsback SF Thulke HH Weiner J Wiegand T DeAngelis DL 《Science (New York, N.Y.)》2005,310(5750):987-991
Agent-based complex systems are dynamic networks of many interacting agents; examples include ecosystems, financial markets, and cities. The search for general principles underlying the internal organization of such systems often uses bottom-up simulation models such as cellular automata and agent-based models. No general framework for designing, testing, and analyzing bottom-up models has yet been established, but recent advances in ecological modeling have come together in a general strategy we call pattern-oriented modeling. This strategy provides a unifying framework for decoding the internal organization of agent-based complex systems and may lead toward unifying algorithmic theories of the relation between adaptive behavior and system complexity. 相似文献