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Kathryn Y. Bray Karen R. Muñana Kristina Meichner Laura A. White Gabriela Seiler 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2016,45(4):698-702
A 12‐year‐old cat was presented for evaluation of progressive tetraparesis. Magnetic resonance imaging of the cervical spine demonstrated T2‐hyperintensity, and contrast enhancement within the C4–C7 spinal cord, with marked meningeal contrast enhancement and segmental nerve root thickening. Lumbar cerebrospinal fluid contained 407 total nucleated cells/μL, with 99% eosinophils. The cat transiently improved with prednisolone, clindamycin, and ivermectin therapy, but subsequently worsened and was euthanized. Necropsy revealed an asymmetric infiltration predominantly of the white matter, meninges, and nerve roots of the C4–C6 spinal cord segments by an unencapsulated, poorly demarcated neoplasm composed of atypical lymphocytes admixed with eosinophils, causing perivascular hemorrhage and lytic necrosis. The neoplastic cells were immunoreactive for CD3, ultimately confirming T‐cell lymphoma. 相似文献
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John P. Sundberg† Kathleen A. Silva Weidong Zhang Beth A. Sundberg Kathryn Edwards‡ Lloyd E. King† Robert L. Davis§ Steven Black¶ 《Veterinary dermatology》2009,20(2):99-104
Untoward effects of human vaccines suggest that recombinant hepatitis B vaccine may induce alopecia areata (AA) in some patients. Similar untoward immunological effects may also account for AA-like diseases in domestic species. In this study, the C3H/HeJ spontaneous adult onset AA mouse model was used to test the role, if any, of recombinant hepatitis B vaccine on the initiation or activation of AA. Initial experiments demonstrated no effect on induction of AA in young adult female C3H/HeJ mice ( P = 0.5689). By contrast, older females, those at the age when AA first begins to appear in this strain, had a significant increase ( P = 0.0264) in the time of onset of AA, suggesting that the vaccine may initiate disease in mice predisposed to AA. However, larger vaccine trials, which included diphtheria and tetanus toxoids as additional controls, did not support these initial result findings and suggest that AA associated with vaccination may be within the normal background levels of the given population. 相似文献
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Luis R Padilla Kathryn P Huyvaert Jane Merkel R Eric Miller Patricia G Parker 《Journal of zoo and wildlife medicine》2003,34(3):278-283
Venipuncture was performed on 50 adult, free-ranging waved albatrosses (Phoebastria irrorata) on Espa?ola, Galapagos Islands, Ecuador, to establish hematologic and plasma biochemistry reference ranges and to determine the prevalence of exposure to important domestic avian pathogens. Weights and plasma creatine phosphokinase activities differed significantly between males and females. Serum was tested for evidence of exposure to avian influenza, avian paramyxoviruses 1, 2, and 3, avian cholera, adenovirus groups 1 and 2, avian encephalomyelitis, Marek's disease, infectious bursal disease, and infectious bronchitis virus (Connecticut and Massachusetts strains). Of 44 birds, 29 (66%) seroreacted to adenovirus group 1, and four seroreacted to avian encephalomyelitis. Cloacal swabs were negative for Chlamydophila psittaci DNA. 相似文献
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Kathryn?M.?IrvineEmail author T.?J.?Rodhouse Ilai?N.?Keren 《Journal of Agricultural, Biological & Environmental Statistics》2016,21(4):619-640
Ecological abundance data are often recorded on an ordinal scale in which the lowest category represents species absence. One common example is when plant species cover is visually assessed within bounded quadrats and then assigned to pre-defined cover class categories. We present an ordinal beta hurdle model that directly models ordinal category probabilities with a biologically realistic beta-distributed latent variable. A hurdle-at-zero model allows ecologists to explore distribution (absence) and abundance processes in an integrated framework. This provides an alternative to cumulative link models when data are inconsistent with the assumption that the odds of moving into a higher category are the same for all categories (proportional odds). Graphical tools and a deviance information criterion were developed to assess whether a hurdle-at-zero model should be used for inferences rather than standard ordinal methods. Hurdle-at-zero and non-hurdle ordinal models fit to vegetation cover class data produced substantially different conclusions. The ordinal beta hurdle model yielded more precise parameter estimates than cumulative logit models, although out-of-sample predictions were similar. The ordinal beta hurdle model provides inferences directly on the latent biological variable of interest, percent cover, and supports exploration of more realistic ecological patterns and processes through the hurdle-at-zero or two-part specification. We provide JAGS code as an on-line supplement. Supplementary materials accompanying this paper appear on-line. 相似文献
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Kathryn M. Irvine Alix I. Gitelman Jennifer A. Hoeting 《Journal of Agricultural, Biological & Environmental Statistics》2007,12(4):450-469
In a spatial regression context, scientists are often interested in a physical interpretation of components of the parametric
covariance function. For example, spatial covariance parameter estimates in ecological settings have been interpreted to describe
spatial heterogeneity or “patchiness” in a landscape that cannot be explained by measured covariates. In this article, we
investigate the influence of the strength of spatial dependence on maximum likelihood (ML) and restricted maximum likelihood
(REML) estimates of covariance parameters in an exponential-with-nugget model, and we also examine these influences under
different sampling designs—specifically, lattice designs and more realistic random and cluster designs—at differing intensities
of sampling (n=144 and 361). We find that neither ML nor REML estimates perform well when the range parameter and/or the nugget-to-sill
ratio is large—ML tends to underestimate the autocorrelation function and REML produces highly variable estimates of the autocorrelation
function. The best estimates of both the covariance parameters and the autocorrelation function come under the cluster sampling
design and large sample sizes. As a motivating example, we consider a spatial model for stream sulfate concentration. 相似文献
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As large, long-lived seabirds with delayed and slow reproduction, albatrosses have low intrinsic mortality rates and are especially vulnerable to extinction from extrinsic sources of mortality such as fishery bycatch. Leg-band recovery information for waved albatrosses revealed mortality from both incidental catch and intentional catch for human consumption. Annual adult survival in 1999-2005, estimated from capture-mark-recapture data, was lower than historical estimates. This recent increase in adult mortality probably contributed to recent and dramatic shrinkage of the breeding population; periodic matrix models confirm that population growth rate is most sensitive to changes in adult survival. Banding data and recovery information also suggest that capture by fisheries is male-biased, which should reduce fecundity in this species with obligate bi-parental care. This new documentation of bycatch, harvesting, and associated demographic consequences provides reason for serious concern about the persistence of the single breeding population of the waved albatross. 相似文献