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41.
K P Baker 《The Journal of small animal practice》1971,12(8):445-452
The diagnosis and treatment of skin disease form a major part of the small animal practitioner's work. A significant number of cases will be allergic in nature and may present difficulties in diagnosis. In man, skin testing for allergy is an established aid to diagnosis, but has been little used by the small animal veterinarian; published results are few. This paper is a preliminary report of the results of skin tests using allergens on normal and allergic dogs. It is considered that the method is of value as an aid to the diagnosis of flea hypersensitivity, but that the preliminary results using other allergens are inconclusive. Résumé. Le diagnostic et le traitement de dermatoses constituent une partie importante du travail du vétérinaire spécialisé dans le traitement d'animaux domestiques. De par la nature allergique d'un nombre considérable de cas, leur diagnostic peut poser des problèmes. Chez l'homme, les essais dermiques pour déterminer l'allergie sont reconnus comme facilitant le diagnostic; les vétérinaires, toutefois, n'y ont pas souvent recours et rares sont les résultats publiés dans ce domaine. Cette communication est un rapport préliminaire des résultats qu'ont fournis les essais dermiques en usant des allergènes chez des chiens normaux et ailergiques. On estime que la méthode a de la valeur en ce sens qu'elle aide à établir le diagnostic de l'hypersensibilité aux puce, mais que les résultats préliminaires avec d'autres allergènes sont peu concluants. Zusammenfassung. Die Diagnose und die Behandlung von Hautkrankheiten stellen einen grossen Teil der Arbeit des praktkchen Tierarztes dar. Eine nicht unbedeutende Zahl von Fällen wird allergischer Natur sein und kann diagnostische Schwierigkeiten bieten. Beim Menschen ist die Prüfung der allergischen Reaktion der Haut ein anerkanntes Mittel der Diagnose, das jedoch in der tierärztlichen Praxis wenig angewendet wurde, und auch Veröffentlichungen über die Ergebnisse sind selten. Die vorliegende Arbeit ist ein vorläufiger Bericht über die Ergebnisse von Hauttests unter Verwendung von Allergenen an normalen und allergischen Hunden. Man darf annehmen, dass die Methode einen Wert als diagnostisches Hilfsmittel im Falle der Überempfindlichkeit gegen Flöhe besitzt, dass die vorläufigen Ergebnisse der Verwendung anderer Allergene aber nicht eindeutig sind. 相似文献
42.
An outbreak of salmonellosis in sheep 总被引:1,自引:0,他引:1
43.
Henderson SM Baker J Williams R Gunn-Moore DA 《Journal of Feline Medicine and Surgery》2003,5(1):37-41
An 18-month-old domestic short-haired neutered male cat presented with a nodular dermal thickening on a digit. Biopsy demonstrated pyogranulomatous inflammation with moderately frequent acid-fast bacilli. A member of theMycobacterium terrae complex was isolated. There was no evidence of systemic involvement. Treatment was initiated with enrofloxacin, rifampicin and clarithromycin. After 2 months there was no longer any clinically apparent dermal thickening. Treatment was continued for a further 3 months using enrofloxacin and rifampicin. 相似文献
44.
Angus bulls (n = 16) selected for either high- or low-milk EPD but similar growth EPD were mated within location at random to Angus cows. Daughters were bred to calve at 2 yr of age and annually until 6 yr of age. Milk yield was measured four times during lactation with a portable milking machine to estimate 12-h milk yield. Milk was collected for analysis of the percentage of fat and protein. A mixed model procedure was used to analyze the weaning weight, milk yield, and milk component data. The model for weaning weight included location, genetic line of sire, gender of calf, and age of dam. Calf age at weaning was used as a covariate. The model for the milk yield and components included location, genetic line of sire, gender of calf, period, and age of dam. Random effects for all models included sire of dam nested within line, sire of calf, and year. Genetic line was a significant source of variation for milk yield (P < 0.01) and weaning weight (P < 0.01) but not for percentage of fat or protein. Location was significant for milk yield (P < 0.01), fat (P < 0.01), protein (P < 0.01), and weaning weight (P < 0.01). The interaction of line with location was not significant except for percentage of protein (P < 0.01). Age of dam was significant for milk yield (P < 0.01), weaning weight (P < 0.01), and percentage of protein (P < 0.01), but not for percentage of fat (P = 0.29). Line difference for mean weaning weight was 18.1 kg, which is similar to the difference between lines for milk EPD (19 kg). Weaning weights from high-milk EPD line daughters were heavier (P < 0.01) than low-milk EPD line daughters at each age of dam evaluated. Cows nursed by males had higher milk yields (4.33 kg/12 h) than cows nursed by heifers (4.0 kg/12 h). The difference in yields for gender was significant for 2-, 3-, and 5-yr-old cows, but not for 4- (P < 0.052) and 6-yr old (P < 0.15) cows. Correlation coefficients between weaning weight and weaning EPD, milk EPD, and total maternal EPD were greater than zero (P < 0.01) (0.76, 0.65, and 0.89, respectively). Daughters of sires with high-milk EPD produced more milk at each age and weaned heavier calves than daughters of sires with low-milk EPD. These results confirm the value of milk EPD for improvement of weaning weights in beef cattle and also validate age of dam effects on milk yield and the associated effects on weaning weights. 相似文献
45.
Richter RA Freeman DE Wallig M Whittem T Baker GJ 《American journal of veterinary research》2002,63(7):934-941
OBJECTIVES: To study the functional and structural responses of the right dorsal colon (RDC) of ponies to phenylbutazone (PBZ) in vitro at a concentration that could be achieved in vivo. ANIMALS: 8 adult ponies. PROCEDURE: Short circuit current and conductance were measured in mucosa from the RDC. Tissues incubated with and without HCO3- were exposed to PBZ, bumetanide, or indomethacin. Bidirectional Cl- fluxes were determined. After a baseline flux period, prostaglandin E2 (PGE2) was added to the serosal surfaces and a second flux period followed. Light and transmission electron microscopy were performed. RESULTS: Baseline short circuit current was diminished significantly by PBZ and indomethacin, and increased significantly after addictions of PGE2. After PGE2 was added, Cl- secretion increased significantly in tissues in HCO3- -free solutions and solutions with anti-inflammatory drugs, compared with corresponding baseline measurements and with control tissues exposed to PGE2. Bumetanide did not affect baseline short circuit current and Cl- fluxes. The predominant histologic change was apoptosis of surface epithelial cells treated with PBZ and to a lesser extent in those treated with indomethacin. CONCLUSIONS AND CLINICAL RELEVANCE: Prostaglandin-induced Cl- secretion appeared to involve a transporter that might also secrete HCO3-. Both PBZ and indomethacin altered ion transport in RDC and caused apoptosis; PBZ can damage mucosa through a mechanism that could be important in vivo. The clinically harmful effect of PBZ on equine RDC in vivo could be mediated through its effects on Cl- and HCO3- secretion. 相似文献
46.
de Veau IF Pedersoli W Cullison R Baker J 《Journal of veterinary pharmacology and therapeutics》2002,25(3):195-200
Phenylbutazone was administered intravenously to a group of 11 beef steers at a dosage of 6 mg/kg of body weight. Whole plasma and protein-free plasma were analyzed for phenylbutazone residues. Pharmacokinetic parameters of total and free phenylbutazone in plasma were calculated using a noncompartmental method. In regards to whole plasma data, the mean volume of distribution at steady state (Vss), was 140 mL/kg body weight, with a mean (+/-SEM) terminal elimination half-life (t1/2) of 34 +/- 9 h. The mean clearance was 3.2 mL/h/kg body weight. The Vss, as determined from the protein-free plasma fraction, was 54093 mL/kg body weight. This larger Vss of free phenylbutazone compared with total plasma phenylbutazone was attributed to a high degree of plasma protein binding, as well as the greater penetration of free phenylbutazone into tissues. The mean t1/2 of free phenylbutazone was 35 +/- 12 h. This similarity to the t1/2 estimated from total plasma phenylbutazone data is attributed to an equilibrium between free and plasma phenylbutazone during the terminal elimination phase. The pharmacokinetic parameters of free and total plasma phenylbutazone in beef steers are statistically similar to those previously reported for lactating dairy cows. 相似文献
47.
Gaynor JS Brevard S Mallinckrodt C Baker G Wander K 《Veterinary therapeutics : research in applied veterinary medicine》2002,3(4):425-434
A randomized, placebo-controlled, parallel study was conducted to investigate the effectiveness of oral carprofen for the control of postoperative pain in dogs undergoing knee surgery for stabilization of ruptured cranial cruciate ligaments. Dogs were randomly assigned to treatment with carprofen (n = 10) or placebo (n = 9). Pain was assessed at 1, 2, 4, 6, 24, and 48 hours and 10 and 21 days postoperatively. Eight of 10 dogs treated with carprofen and five of nine dogs treated with placebo were given at least one dose of morphine as rescue therapy. The mean relative dose of morphine given at 1 hour (P =.01) and 24 hours (P =.02) after surgery was greater for dogs treated with carprofen than for dogs given a placebo. There were no significant postoperative differences in cortisol levels or any measured variable. It appears that the scoring system used was not sensitive enough to detect differences in pain between a known analgesic and a placebo. 相似文献
48.
49.
Magid JH Manohar M Goetz TE Baker GJ Ulbricht R Bontkowski S Ghantous S 《Journal of veterinary pharmacology and therapeutics》2000,23(2):81-89
Furosemide premedication of horses 4 h prior to exercise significantly attenuates exercise-induced pulmonary capillary hypertension which may help diminish the severity of exercise-induced pulmonary haemorrhage. As pulmonary hemodynamic effects of furosemide may be mediated via a reduction in plasma volume (which is most pronounced 15-30 min postfurosemide administration, with plasma volume recovering thereafter), we hypothesized that administration of furosemide at intervals shorter than 4 h before exertion may be more effective in attenuating the exercise-induced rise in pulmonary capillary blood pressure. Thus, our objective was to determine whether furosemide-induced attenuation of exercise-induced pulmonary arterial, capillary and venous hypertension would be enhanced when the drug is administered at intervals shorter than 4 h before exercise. Using established techniques, right atrial, and pulmonary arterial, capillary and wedge (venous) pressures were ascertained in seven healthy, sound, exercise-trained Thoroughbred horses in a randomized split-plot experimental design. Measurements were made at rest and during exercise performed at maximal heart rate (217 +/- 3 beats/min) in the control (no medications) experiments and following furosemide administration (250 mg intravenously (i.v.)) at 1, 2, 3 and 4 h before exercise. Sequence of treatments was randomized and 7 days were allowed between experiments on each horse. Although furosemide administration in the four treatment groups caused only insignificant changes in the pulmonary arterial, capillary and wedge pressures of standing horses, furosemide-induced reduction in mean right atrial pressure achieved statistical significance in the 2 h postfurosemide experiments. In the control studies, exercise was attended by statistically significant increments in mean right atrial, as well as pulmonary arterial, capillary and wedge pressures. Although exercise in each of the four furosemide experiments was also attended by significant increments in right atrial as well as pulmonary vascular pressures, in the 1, 2 and 3 h postfurosemide experiments, mean right atrial pressure increased to a significantly lower value than in the control study. Exercise-induced changes in pulmonary vascular pressures in the 1 h postfurosemide experiments were not different from the pressures in the control study. There was a significant attenuation of exercise-induced pulmonary capillary and venous hypertension in the 2, 3 and 4 h postfurosemide experiments, but significant differences among these treatments were not found. Thus, these data did not support the contention that administration of furosemide at intervals shorter than 4 h before exercise is more effective in attenuating exercise-induced pulmonary capillary or venous hypertension in Thoroughbred horses. 相似文献
50.
FJ Pena JA Gines J Duque V Vieitez R Martinez –Pérez L Madejón I Nuñez Martinez JM Moran S Fernández-García 《Reproduction in domestic animals》2006,41(2):189-190
A 6-year-old female Alaska Malamute dog was presented for evaluation of abdominal enlargement referred by a local veterinarian. On the history, the owner complained of chronic abdominal enlargement initiated more than 4 months ago, reduced appetite, occasional vomiting and general dullness. He also complained of greenish mucous intermittent vaginal discharge starting 10 days ago. The bitch was chronically treated with medroxiprogesterone acetate. A laparatomy was performed and fluid in the abdomen was found and aspirated during the surgery. Also a very fluid-filled distended uterus and a mass in the distal part of the left uterine horn were found. The mass was encapsulated by the omentum, but areas of necrosis and calcification were identified. Histopathological diagnosis was endometrial adenocarcinoma. 相似文献