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991.
Liaqat Ali Abdul Latif Khan Lubna Al-Kharusi Javid Hussain Ahmed Al-Harrasi 《Marine drugs》2015,13(7):4344-4356
The marine ecosystem has been a key resource for secondary metabolites with promising biological roles. In the current study, bioassay-guided phytochemical investigations were carried out to assess the presence of enzyme inhibitory chemical constituents from the methanolic extract of marine green alga—Codium dwarkense. The bioactive fractions were further subjected to chromatographic separations, which resulted in the isolation of a new triterpenic acid; dwarkenoic acid (1) and the known sterols; androst-5-en-3β-ol (2), stigmasta-5,25-dien-3β,7α-diol (3), ergosta-5,25-dien-3β-ol (4), 7-hydroxystigmasta-4,25-dien-3-one-7-O-β-d-fucopyranoside (5), 7-hydroxystigmasta-4,25-dien-3-one (6), and stigmasta-5,25-dien-3β-ol (7). The structure elucidation of the new compound was carried out by combined mass spectrometry and 1D (1H and 13C) and 2D (HSQC, HMBC, COSY, and NOESY) NMR spectroscopic data. The sub-fractions and pure constituents were assayed for enzymatic inhibition of alpha-glucosidase. Compound 1 showed significant inhibition at all concentrations. Compounds 2, 3, 5, and 7 exhibited a dose-dependent response, whereas compounds 4–6 showed moderate inhibition. Utilizing such marine-derived biological resources could lead to drug discoveries related to anti-diabetics. 相似文献
992.
Mohamed R. Akl Nehad M. Ayoub Hassan Y. Ebrahim Mohamed M. Mohyeldin Khaled Y. Orabi Ahmed I. Foudah Khalid A. El Sayed 《Marine drugs》2015,13(1):288-311
Receptor tyrosine kinases are key regulators of cellular growth and proliferation. Dysregulations of receptor tyrosine kinases in cancer cells may promote tumorigenesis by multiple mechanisms including enhanced cell survival and inhibition of cell death. Araguspongines represent a group of macrocyclic oxaquinolizidine alkaloids isolated from the marine sponge Xestospongia species. This study evaluated the anticancer activity of the known oxaquinolizidine alkaloids araguspongines A, C, K and L, and xestospongin B against breast cancer cells. Araguspongine C inhibited the proliferation of multiple breast cancer cell lines in vitro in a dose-dependent manner. Interestingly, araguspongine C-induced autophagic cell death in HER2-overexpressing BT-474 breast cancer cells was characterized by vacuole formation and upregulation of autophagy markers including LC3A/B, Atg3, Atg7, and Atg16L. Araguspongine C-induced autophagy was associated with suppression of c-Met and HER2 receptor tyrosine kinase activation. Further in-silico docking studies and cell-free Z-LYTE assays indicated the potential of direct interaction between araguspongine C and the receptor tyrosine kinases c-Met and HER2 at their kinase domains. Remarkably, araguspongine C treatment resulted in the suppression of PI3K/Akt/mTOR signaling cascade in breast cancer cells undergoing autophagy. Induction of autophagic death in BT-474 cells was also associated with decreased levels of inositol 1,4,5-trisphosphate receptor upon treatment with effective concentration of araguspongine C. In conclusion, results of this study are the first to reveal the potential of araguspongine C as an inhibitor to receptor tyrosine kinases resulting in the induction of autophagic cell death in breast cancer cells. 相似文献
993.
Bernd Krock Urban Tillmann éric Potvin Hae Jin Jeong Wolfgang Drebing Jane Kilcoyne Ahmed Al-Jorani Michael J. Twiner Qun G?thel Matthias K?ck 《Marine drugs》2015,13(11):6687-6702
Two strains of Azadinium poporum, one from the Korean West coast and the other from the North Sea, were mass cultured for isolation of new azaspiracids. Approximately 0.9 mg of pure AZA-36 (1) and 1.3 mg of pure AZA-37 (2) were isolated from the Korean (870 L) and North Sea (120 L) strains, respectively. The structures were determined to be 3-hydroxy-8-methyl-39-demethyl-azaspiracid-1 (1) and 3-hydroxy-7,8-dihydro-39-demethyl-azaspiracid-1 (2) by 1H- and 13C-NMR. Using the Jurkat T lymphocyte cell toxicity assay, (1) and (2) were found to be 6- and 3-fold less toxic than AZA-1, respectively. 相似文献
994.
Ibrahim A.M. Ahmed Abdel M.A. Eltilib Fawzi H.S. Ganawa Emin B. Erenoglu 《Archives of Agronomy and Soil Science》2016,62(1):93-107
Sorghum is one of the water- and nutrient-use efficient crops raised in dry regions worldwide. A 3 × 3 split-plot experiment in randomized complete block design was conducted to study the effects of petroleum refinery waste aqueous ammonia (NH3) on irrigated fodder sorghum for two consecutive growing seasons. The main plots consisted of 0 (control), 40, and 80 kg N ha?1, respectively, and the injection depths (surface 15 cm, and 20 cm depth) were assigned to sub-plots. A significant effect of NH3 on both fresh and dry biomass production was observed where the highest yield was recorded from the 80 kg N ha?1 than the control and 40 kg N ha?1, respectively. Sorghum biomass yield increased most when NH3 was injected at 20 cm depth as compared to other depths. Biomass nutrient content and nitrogen-use efficiency were increased when 80 kg N ha?1 was applied as compared to the control. The critical limit of K:(Ca+Mg), above which the tetany risk increases, did not exceed in sorghum biomass by NH3 fertilization. Results suggested that industrial waste NH3 equivalent to 80 kg N ha?1 injected at 20 cm depth can be a sustainable approach to fertilize irrigated sorghum growing as a forage crop. 相似文献
995.
Ahmed M. Elhendy Abdulaziz A. Alzoom 《Aquaculture Economics & Management (Blackwell Science)》2013,17(3-4):229-238
Abstract Because Saudi Arabia is a substantial importer of fish and its capture fishery is operating beyond maximum sustainable limits, it has a special interest in developing fish farming. It has been encouraging tilapia production. This study examines the costs of tilapia farming in the Central Region of Saudi Arabia using cross sectional data from 23 intensive fish farms. It provides information about the relative importance of different cost items such as variable costs and feed costs in total costs. Also, cost functions are estimated by ordinary least squares and a cubic cost function is found to provide the best fit to the available data. Minimum average cost of production occurs for 201 tonnes of tilapia per year per farm and profit is maximised for a production of 300 tonnes annually per farm. All farms operate at less than profit‐maximising scale and most operate at less than minimum efficient scale. The reasons could be low quality fry, low levels of management expertise in culturing tilapia and the secondary nature of tilapia farming. Lack of water is likely to limit future expansion of tilapia farming in Saudi Arabia. 相似文献
996.
Madan M. Dey M. A. Rab K. M. Jahan A. Nisapa A. Kumar M. Ahmed 《Aquaculture Economics & Management (Blackwell Science)》2013,17(1-2):217-236
ABSTRACT Developing Asian countries continue to record an impressive trade surplus in fish products. However, raising consumer concerns about a range of food safety matters and increasingly stringent regulatory standards related to fish product supply pose on-going challenges to the sustained international market access of many developing country suppliers. This paper provides an overview of emerging trade patterns in fish products and the trade regime in which this is occurring. It then reviews the implementation of various food safety standards on fish and seafood exports in the major fish-exporting countries in Asia, and analyzes the costs and benefits of compliance with these standards and regulations in these countries. Results show that, at the factory level, implementation of the standards has significantly increased the cost of processing, and the cost per unit of fish processed is higher for the smaller plants. These economies of scale could exclude small operators in developing countries. Continued competitiveness of small plants would seem to require government policies and support designed to minimize the cost of compliance with international standards. 相似文献
997.
Nesar Ahmed Catherine Lecouffe Edward H. Allison James F. Muir 《Aquaculture Economics & Management (Blackwell Science)》2013,17(3):246-269
A conceptual framework, drawn from an approach to poverty reduction known as the Sustainable Livelihoods Approach (SLA), is applied to understanding the role of freshwater prawn (Macrobrachium rosenbergii) marketing systems in southwest Bangladesh. Freshwater prawn marketing potentially provides economic returns and social benefits to the rural poor. Although the potential benefits are great, a number of constraints were identified for the long-term sustainability of prawn marketing systems. The study used the SLA framework as an analytical tool to identify ways to strengthen livelihoods of prawn traders and associated groups. 相似文献
998.
Faruq Ahmed Yasuyuki Koike Carlos Augusto Strüssmann Seiichi Watanabe 《Aquaculture International》2013,21(5):969-986
Effect of stocking density was studied in three abalone species Haliotis discus discus (HDD), H. gigantea (HG), and H. madaka (HM) and their hybrids [HDD × HM, HM × HG and HG × HM, mother first] by rearing individually marked abalones for 217 days at low (22 % of available surface area; LD), medium (53 %; MD), and high (126 %; HD) densities. Feeding rate (FR) and feed conversion rate were observed by measuring the amount of feed ingested at an interval of 2–3 days. Reduction of growth rate with the increment of density was found in all three species [Specific growth rate in weight (G W ) HDD, LD: 0.121, MD: 0.093, HD: 0.069; HM: 0.12, 0.082, 0.061; HG: 0.254, 0.222, and 0.131] and the hybrids HDD × HM (0.18, 0.109, 0.108). The medium density produced the highest growth rates in HM × HG and HG × HM hybrids (0.284, 0.342, 0.28). A growth spurt was observed in all three species and hybrids in the last 44 days of rearing. FR varied from 0.72 to 7.97 % body weight and decreased with the increase in density in all species and hybrids. The results indicate differences in density thresholds for the three abalone species and their hybrids suggesting requirement of different aquaculture management strategies for them. 相似文献
999.
Irfan Mustafa Muhammad Arshad Abdul Ghani Iftikhar Ahmad Abu Bakar Muhammad Raza Farzana Saddique Saira Asif Mobushir Riaz Khan Haroon Ahmed 《Phytoparasitica》2014,42(3):341-348
From January 2010 to December 2011, samples of leaves from citrus varieties Kinnow, Musambi and Feutral were taken from the five tehsils (administrative subdivisions) of Sargodha District in Pakistan including Sargodha, Bahalwal, Silanwalli, Sahiwal and Kotmomin, to study the population trends in citrus leaf miner (CLM), Phyllocnistis citrella (Stainton) (Lepidoptera: Gracillariidae), and its correlation with various environmental factors: (temperature, humidity and rainfall); plant morphological factors: moisture contents of leaves, leaf thickness, surface area (cm 2 ), and biochemical percentage of calcium, potassium and magnesium in leaves. The maximum population of CLM was observed on Kinnow and Feutral, followed by Musambi. The effect of these factors on the larval population was 8.39- 2.30(Mg)+2.73(K)-0.398(Ca)-0.100(Temp)0.038(Humidity)+0.567(Rain)+0.07(Moist) 1.01 (Thickness)-0.022(Surface area). This equation revealed that magnesium, calcium, temperature, humidity, leaf thickness and leaf surface area are negatively correlated with larvae population, whereas potassium, rainfall and moisture are positively correlated with larvae population. 相似文献
1000.
Md. Kawser Ahmed Shamima Sultana Sadeka Halim Md. Monirul Islam 《Aquaculture Economics & Management (Blackwell Science)》2016,20(3):272-282
The present study analyzes the prawn marketing chain before and after the implementation of a Danish-funded project (GNAEP) in three coastal districts of greater Noakhali, southeast region of Bangladesh. The results reveal that, before GNAEP, there was a longer prawn marketing chain with a number of intermediaries who used to share a considerable amount of market margin. However, after implementation of GNAEP, the prawn marketing chain has become shorter with a significant reduction of intermediaries which facilitates direct selling of prawns to processing plants through local Community Based Organizations (CBOs). The present prawn marketing system in the regions is in favor of prawn farmers. Farmers have greater advantages because 1) CBOs provide reasonable market price and actual weight, 2) CBOs can bargain with processing plants as the former are aware of the latest international market prices through Marketing Information System 3) number of intermediaries is lowered and 4) transport and preservation costs are reduced. The displaced intermediaries, some of whom are powerful persons in the society, have again started to influence the prawn market in different ways. This fact has opened up another discussion on how the power structure is shifting in this region and how they are affecting prawn marketing. 相似文献