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101.
Cholera: new aids in treatment and prevention 总被引:1,自引:0,他引:1
M M Adams 《Science (New York, N.Y.)》1973,179(73):552-555
102.
Pentapeptide (proctolin) associated with an identified neuron 总被引:2,自引:0,他引:2
Individual neurons can be recognized and identified anatomically, physiologically, and biochemically in the insect central nervous system. Biochemical analyses of extracts prepared from one such identified neuron show it to be associated with a bioactive pentapeptide called proctolin. This peptide may be a neurotransmitter, and a preparation is established in which its physiological action can be studied at the cellular level. 相似文献
103.
Chronic arthritis in goats caused by a retrovirus 总被引:46,自引:0,他引:46
A virus was isolated from an adult goat with chronic arthritis and shown to belong to the retrovirus group by electron microscopy and biochemical methods. Inoculation of the virus into cesarean-derived specific-pathogen-free goats' kids produced arthritic lesions similar to those in the spontaneous disease. Vrus was reisolated from the experimentally induced lesions. 相似文献
104.
Clonal characteristics of experimentally induced "atherosclerotic" lesions in the hybrid hare 总被引:2,自引:0,他引:2
T A Pearson J Dillman K J Williams J A Wolff R Adams K Solez R H Heptinstall H Malmros N Sternby 《Science (New York, N.Y.)》1979,206(4425):1423-1425
The female hybrid hare (Lepus timidus x Lepus europaeus) is heterozygous for electrophoretically separable, X-linked isoenzymes of glucose-6-phosphate dehydrogenase. The isoenzymes of this animal have been used as cellular markers in the study of the clonal origins of experimentally induced atherosclerotic lesions. Aortic lesions produced in the hybrid hare by feeding cholesterol and injuring the aortic wall with a catheter have been shown to have polyclonal characteristics and in this way are fundamentally different from atherosclerotic fibrous plaques in man. 相似文献
105.
Native and renatured transfer ribonucleic acid 总被引:3,自引:0,他引:3
Transfer ribonucleic acid, isolated under conditions in which the original macromolecular structure is never denatured, is indistinguishable from transfer ribonucleic acid prepared by conventional methods involving denaturing steps. This finding is consistent with the absence of direct genetic control of the formation of macromolecular structure of transfer ribonucleic acid. 相似文献
106.
Wood versus fossil fuel as a source of excess carbon dioxide in the atmosphere: a preliminary report
If the amounts of wood consumed in deforestation to increase agricultural land and as firewood in underindustrialized countries are added to the amount consumed by the money economies as forest products, the estimates of the net amount of wood removed from the biosphere in this century should be revised upward. The per capita ratio of the weight of carbon from net wood burned to the weight of carbon from fossil fuel burned in this century has been at least 0.1 and may have approached 1.0. 相似文献
107.
108.
Role of Na+/H+ exchange by interferon-gamma in enhanced expression of JE and I-A beta genes 总被引:6,自引:0,他引:6
V Prpic S F Yu F Figueiredo P W Hollenbach G Gawdi B Herman R J Uhing D O Adams 《Science (New York, N.Y.)》1989,244(4903):469-471
The rapid transductional sequences initiated by interferon-gamma (IFN-gamma) on binding to its receptor regulate functional and genomic responses in many cells but are not well defined. Induction of macrophage activation is an example of such functional and genomic changes in response to IFN-gamma. Addition of IFN-gamma to murine macrophages, at activating concentrations, produced rapid (within 60 seconds) alkalinization of the cytosol and a concomitant, rapid influx of 22Na+. Amiloride inhibited the ion fluxes and the accumulation of specific messenger RNA for two genes induced by IFN-gamma (the early gene JE and the beta chain of the class II major histocompatibility complex gene I-A). The data indicate that IFN-gamma initiates rapid exchange of Na+ and H+ by means of the Na+/H+ antiporter and that these amiloride-sensitive ion fluxes are important to some of the genomic effects of IFN-gamma. 相似文献
109.
110.
Gammadelta T cell receptors (TCRs), alphabeta TCRs, and antibodies are the three lineages of somatically recombined antigen receptors. The structural basis for ligand recognition is well defined for alphabeta TCR and antibodies but is lacking for gammadelta TCRs. We present the 3.4 A structure of the murine gammadelta TCR G8 bound to its major histocompatibility complex (MHC) class Ib ligand, T22. G8 predominantly uses germline-encoded residues of its delta chain complementarity-determining region 3 (CDR3) loop to bind T22 in an orientation substantially different from that seen in alphabeta TCR/peptide-MHC. That junctionally encoded G8 residues play an ancillary role in binding suggests a fusion of innate and adaptive recognition strategies. 相似文献