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排序方式: 共有186条查询结果,搜索用时 31 毫秒
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Graciela Pineda‐Valdes Dojin Ryu David S. Jackson Lloyd B. Bullerman 《Cereal Chemistry》2002,79(6):779-782
The incidence of moniliformin (MON) producing Fusarium spp. in selected corn (Zea mays L.) samples from Mexico and the United States and the effects of alkaline cooking and the tortilla manufacturing processes on the reduction of MON were determined. The percentage of infected kernels with Fusarium spp. ranged from 0 to 22% in eight foodgrade corn samples, including six from Mexico and two from the United States. Complete (100%) reduction of MON was observed when a naturally contaminated corn sample containing 1.4 μg of MON/g of corn was used in a pilot‐scale alkaline cooking and tortilla manufacturing process. In a companion laboratory‐scale study, using a cultured corn sample containing 17.6 μg of MON/g of corn, a 71% reduction of the toxin was observed during the process. Alkaline cooking appeared to be an effective method for reduction of MON in corn. 相似文献
74.
Hye-Won Yang Seyeon Oh Dong-Min Chung Minyoung Seo Shin Jae Park You-Jin Jeon Kyunghee Byun BoMi Ryu 《Marine drugs》2022,20(5)
The in vitro capacity of Ishige okamurae extract (IO) to improve impaired muscle function has been previously examined. However, the mechanism underlying IO-mediated muscle protein metabolism and the role of its component, Ishophloroglucin A (IPA), in mice with dexamethasone (Dexa)-induced muscle atrophy remains unknown. In the present study, we evaluated the effect of IO and IPA supplementation on Dexa-induced muscle atrophy by assessing muscle protein metabolism in gastrocnemius and soleus muscles of mice. IO and IPA supplementation improved the Dexa-induced decrease in muscle weight and width, leading to enhanced grip strength. In addition, IO and IPA supplementation regulated impaired protein synthesis (PI3K and Akt) or degradation (muscle-specific ubiquitin ligase muscle RING finger and atrogin-1) by modulating mRNA levels in gastrocnemius and soleus muscles. Additionally, IO and IPA upregulated mRNA levels associated with muscle growth activation (transient receptor potential vanilloid type 4 and adenosine A1 receptor) or inhibition (myostatin and sirtuin 1) in gastrocnemius and soleus muscle tissues of Dexa-induced mice. Collectively, these results suggest that IO and IO-derived IPA can regulate muscle growth through muscle protein metabolism in Dexa-induced muscle atrophy. 相似文献
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Ryu J Seo J Lee Y Lim Y Ahn JH Hur HG 《Journal of agricultural and food chemistry》2005,53(15):5954-5958
Bacterial strain JYR-1, which utilizes high concentrations (up to 100 mM) of trans-anethole as the sole source of carbon and energy, was isolated from soil. It grew to OD(600)(nm) = 2.6 with a doubling time of 8 h when grown on 20 mM trans-anethole. Strain JYR-1 was identified as Pseudomonas putida based on the partial gene sequence of its 16S rDNA. Elution profiles of culture extracts were examined by high-performance liquid chromatography and showed that four metabolites were produced from the bacterial culture containing trans-anethole that were not detected in control experiments. LC-MS analysis showed molecular weights of 138.2, 164.5, 164.3, and 152.3. The metabolites with molecular weights at 152.3 and 138.2 were confirmed to be p-anisic acid and p-hydroxybenzoic acid, respectively, when compared with HPLC retention times and molecular weights of authentic compounds. The metabolites with molecular weights at 164.5 and 164.3 were further analyzed by NMR and were proved to be stereoisomer syn- and anti-anethole epoxides. Therefore, strain JYR-1 most likely initiates the metabolism of trans-anethole through the formation of epoxides on the propene group of the compound. 相似文献
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Effect of dihydrotestosterone on mouse embryonic stem cells exposed to H2O2-induced oxidative stress
Mi Na Lee Sang Hun Lee Min Young Lee Yun Hee Kim Jae Hong Park Jung Min Ryu Seung Pil Yun Yu Jin Lee Mi Ok Kim Kwangsung Park Ho Jae Han 《Journal of veterinary science (Suw?n-si, Korea)》2008,9(3):247-256
Oxidative stresses induced by reactive oxygen species (ROS) have been shown to be involved in several physiological and pathophysiological processes, such as cell proliferation and differentiation. Steroid hormones can protect cells against apoptosis or induce cell proliferation by several mechanisms. Among androgenic hormones, dihydrotestosterone (DHT) is generated by a 5α-reduction of testosterone. Unlike testosterone, DHT cannot be aromatized to estradiol, therefore DHT is considered a pure androgenic steroid. This study was conducted to examine the effect of DHT (10-7 M) on H2O2 (10-3 M) -induced injuries in mouse embryonic stem (ES) cells. H2O2 induced ROS generation and increased lipid peroxide formation and DNA fragmentation. These effects of H2O2 were inhibited by pretreatment with DHT. H2O2 also increased the phosphorylation of p38 MAPK, SAPK/JNK and nuclear factor kappa B (NF-κB), but DHT blocked these effects. Moreover, H2O2 decreased DNA synthesis and the levels of cell cycle regulatory proteins [cyclin D1, cyclin E, cyclin-dependent kinase (CDK) 2, and CDK 4]. These effects of H2O2 were inhibited by pretreatment with DHT. In conclusion, DHT may partially prevent H2O2-induced cell injury through inhibition of ROS and ROS-induced activation of p38 MAPK, SAPK/JNK and NF-κB in mouse ES cells. 相似文献
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Hyun-Kyu Park Woori Jo Hyun-Ji Choi Sungwoong Jang Jae-Eun Ryu Hyo-Ju Lee Hyojin Lee Hyejin Kim Eun-Sil Yu Woo-Chan Son 《Journal of veterinary science (Suw?n-si, Korea)》2016,17(1):45-51
Drug-induced liver injury (DILI) is a significant threat to patient health and a major concern during drug development. Recently, multiple circulating microRNAs (miRNAs) have been reported to be potential biomarkers for DILI. To adapt and validate miRNAs for clinical use, we investigated the time-course changes in miR-122 expression levels in an acetaminophen-induced liver injury model in rats. In addition, miR-155 and miR-21 were evaluated as makers of inflammation and regeneration, respectively, to characterize liver status. Our results revealed that miR-122 is an early and sensitive biomarker of hepatocellular injury at a stage when alanine transaminase, aspartate transaminase, and total bilirubin were not detectable. However, no significant differences in the expression levels of other miRNAs (miR-155 and -21) were observed between treatment and vehicle groups. Collectively, these time-course changes in the expression levels of miRNAs may be useful as markers for clinical decision-making, in the diagnosis and treatment of DILI. 相似文献
78.
Expression of the glutamine metabolism‐related proteins glutaminase 1 and glutamate dehydrogenase in canine mammary tumours
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J.‐E. Ryu H.‐K. Park H.‐J. Choi H.‐B. Lee H.‐J. Lee H. Lee E.‐S. Yu W.‐C. Son 《Veterinary and comparative oncology》2018,16(2):239-245
Glutamine metabolism is an important metabolic pathway for cancer cell survival, and there is a critical connection between tumour growth and glutamine metabolism. Because of their similarities, canine mammary carcinomas are useful for studying human breast cancer. Accordingly, we investigated the correlations between the expression of glutamine metabolism‐related proteins and the pathological features of canine mammary tumours. We performed immunohistochemical and western blot analysis of 39 mammary tumour tissues. In immunohistochemical analysis, the expression of glutaminase 1 (GLS1) in the epithelial region increased according to the histological grade (P < .005). In the stromal region, complex‐type tumours displayed significantly higher GLS1 intensity than simple‐type tumours. However, glutamate dehydrogenase expression did not show the same tendencies as GLS1. The western blot results were consistent with the immunohistochemical findings. These results suggest that the expression of GLS1 is correlates with clinicopathological factors in canine mammary tumours and shows a similar pattern to human breast cancer. 相似文献
79.
Tropical Animal Health and Production - Bovine viral diarrhea virus (BVDV), a prominent viral pathogen worldwide, causes substantial economic losses in the cattle industry. BVDV comprises two... 相似文献
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