A correlation of toxicity of albendazole and oxfendazole with their free metabolites and bound residues

The possible correlations between embryotoxicity, plasma kinetics of toxic metabolites and covalent binding of metabolites to foetal tissues were studied using two drugs, albendazole and oxfendazole. In the rat, the metabolic inhibitor, SKF-525A, induced changes in embryotoxicity which were well correlated with plasma levels of identified embryotoxic metabolites, but not with the levels of foetal tissue bound drug metabolites.     

1997-2006年我国核心期刊研究的文献计量分析

采用文献计量学方法,从论文分布、作者分布、发表论文的机构和地区分布、基金资助 等方面对1997-2006年中国期刊全文数据库收录的有关核心期刊研究的论文进行了统计分析 ,对其研究现状和发展趋 势进行探讨,指出了我国有关核心期刊研究的一些不足,并提出了相应的对策。

     

家蚕对8种除草剂农药的毒性反应

近年来农资部门和植保部门出售的除草剂品种繁多,新药不断出现,有许多除草剂在大田作物和桑园中使用,这些除草剂农药对家蚕的毒性如何?笔者等近年来做了大田常用除草剂农药对家蚕的毒性试验,本文报道8种除草剂对家蚕的触杀毒力、安全间隔期及中毒症状,以便为蚕农科学用药提供依据。 1 材料与方法 1.1 供试农药 市售41%农达水剂(美国孟山都公司),72%2,4－D丁酯水剂(河北万全农药厂),盖草能(中国农业生产资料集团公司分装),2%使它隆乳油(美国陶氏益农公司),20%克无踪水溶液(英国卜内门化学工业有限公司),50%高特克悬浮剂(德国艾格福公司),50%扑草劲可湿性粉剂(昆明农药厂)和10%新代力可湿性粉剂(浙江省乐清市乐吉化工厂)共8种。 1.2 供试蚕品种 春季781×782*734,秋季苏3*秋3×苏4*苏12,由省农科院蚕研所春用组提供。 1.3 试验地点及桑品种 在本所生理病理室和桑树研究室进行,6年生油桑品种,低干养成,7500株／ha     

Effect of Dimethyl Sulfoxide on Cell Cycle Synchronization of Goldfish Caudal Fin Derived Fibroblasts Cells

Several studies have previously been conducted regarding cell cycle synchronization in mammalian somatic cells. However, limited work has been performed on the control of cell cycle stages in the somatic cells of fish. The aim of this study was to determine the cell cycle arresting effects of several dimethyl sulfoxide (DMSO) concentrations for different times on different cell cycle stages of goldfish caudal fin‐derived fibroblasts. Results demonstrated that the cycling cells or control group (68.29%) yields significantly higher (p < 0.05) arrest in G0/G1 phase compared with the group treated for 24 h with different concentrations (0.5%, 1.0% or 1.5%) of DMSO (64.88%, 65.70%, 64.22% respectively). The cell cycle synchronization in the treatment of cells with 1.0% DMSO at 48 h (81.14%) was significantly higher than that in the groups treated for 24 h (76.82%) and the control group (77.90%). Observations showed that treatment of DMSO resulted in an increase in the proportion of cells at G0/G1 phase for 48 h of culture. However, high levels of apoptotic cells can be detected after 48 h of culture treated with 1% concentration of DMSO.     

LONG‐TERM MANURING AND FERTILIZER EFFECTS ON DEPLETION OF SOIL ORGANIC CARBON STOCKS UNDER PEARL MILLET‐CLUSTER BEAN‐CASTOR ROTATION IN WESTERN INDIA

Soil organic carbon (SOC) pools are important for maintaining soil productivity and reducing the net CO₂ loading of the atmosphere. An 18‐year old long‐term field experiment involving pearl millet‐cluster bean‐castor sequence was conducted on an Entisol in western India to examine the effects of chemical fertilizers and manuring on carbon pools in relation to crop productivity and C sequestration. The data showed that even the addition of 33.5 Mg ha⁻¹ C inputs through crop residues as well as farm yard manure could not compensate the SOC depletion by oxidation and resulted in the net loss of 4.4 Mg C ha⁻¹ in 18 years. The loss of SOC stock in the control was 12 Mg C ha⁻¹. Conjunctive use of chemical fertilizers along with farm yard manure produced higher agronomic yields and reduced the rate of SOC depletion. The higher average seed yields of pearl millet (809 kg ha⁻¹), cluster bean (576), and castor (827) over six cropping seasons were obtained through integrated use of fertilizers and manure. For every Mg increase in profile SOC stock, there was an overall increase of 0.46 Mg of crop yield, comprising increase in individual yield of pearl millet (0.17 Mg ha⁻¹ y⁻¹ Mg⁻¹ SOC), cluster bean (0.14) and castor (0.15). The magnitude of SOC build up was proportional to the C inputs. Carbon pools were significantly correlated with SOC, which increased with application of organic amendments. Threshold C input of 3.3 Mg C ha⁻¹ y⁻¹ was needed to maintain the SOC stock even at the low antecedent level. Copyright © 2011 John Wiley & Sons, Ltd.     

The differential genetic signatures related to climatic landscapes for jaguars and pumas on a continental scale

Modern and paleoclimate changes may have altered species dynamics by shifting species’ niche suitability over space and time. We analyze whether the current genetic structure and isolation of the two large American felids, jaguar (Panthera onca) and puma (Puma concolor), are mediated by changes in climatic suitability and connection routes over modern and paleoclimatic landscapes. We estimate species distribution under 5 climatic landscapes (modern, Holocene, last maximum glaciations [LMG], average suitability, and climatic instability) and correlate them with individuals’ genetic isolation through causal modeling on a resemblance matrix. Both species exhibit genetic isolation patterns correlated with LMG climatic suitability, suggesting that these areas may have worked as “allele refuges.” However, the jaguar showed higher vulnerability to climate changes, responding to modern climatic suitability and connection routes, whereas the puma showed a continuous and gradual transition of genetic variation. Despite differential responsiveness to climate change, both species are subjected to the climatic effects on genetic configuration, which may make them susceptible to future climatic changes, since these are progressing faster and with higher intensity than changes in the paleoclimate. Thus, the effects of climatic changes should be considered in the design of conservation strategies to ensure evolutionary and demographic processes mediated by gene flow for both species.     

The Effect of Post-Ovulatory Artificial Insemination on Sow Reproductive Performance

In order to increase reproductive performance, sows are usually inseminated several times during oestrus. In practice, this results in a significant number of sows receiving one or more post‐ovulatory inseminations. This study was carried out to determine the percentage of sows that receive one or more post‐ovulatory inseminations and the effect of such treatment on reproductive performance. The results were analysed from a total of 1298 sows on two farms. It was observed that more than 70% of the sows received at least one post‐ovulatory insemination and approximately 20% received two or more. There was no observed effect on the rate of return to oestrus, farrowing rate or litter size (p > 0.05).     

The Nature of the 660-Kilometer Upper-Mantle Seismic Discontinuity from Precursors to the PP Phase

Global Seismic Network data were used to image upper-mantle seismic discontinuities. Stacks of phases that precede the PP phase, thought to be underside reflections from the upper-mantle discontinuities at depths of 410 and 660 kilometers, show that the reflection from 410 kilometers is present, but the reflection from 660 kilometers is not observed. A continuous Lame's constant lambda and seismic parameter at the 660-kilometer discontinuity explain the missing underside P reflections and lead to a P-wave velocity jump of only 2 percent, whereas the S-wave velocity and density remain unchanged with respect to previous global models. The model deemphasizes the role of Lame's constant lambda with regard to the shear modulus and constrains the mineralogical composition across the discontinuity.