排序方式: 共有46条查询结果,搜索用时 406 毫秒
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Chapman MR Robinson LS Pinkner JS Roth R Heuser J Hammar M Normark S Hultgren SJ 《Science (New York, N.Y.)》2002,295(5556):851-855
Amyloid is associated with debilitating human ailments including Alzheimer's and prion diseases. Biochemical, biophysical, and imaging analyses revealed that fibers produced by Escherichia coli called curli were amyloid. The CsgA curlin subunit, purified in the absence of the CsgB nucleator, adopted a soluble, unstructured form that upon prolonged incubation assembled into fibers that were indistinguishable from curli. In vivo, curli biogenesis was dependent on the nucleation-precipitation machinery requiring the CsgE and CsgF chaperone-like and nucleator proteins, respectively. Unlike eukaryotic amyloid formation, curli biogenesis is a productive pathway requiring a specific assembly machinery. 相似文献
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Aspholm-Hurtig M Dailide G Lahmann M Kalia A Ilver D Roche N Vikström S Sjöström R Lindén S Bäckström A Lundberg C Arnqvist A Mahdavi J Nilsson UJ Velapatiño B Gilman RH Gerhard M Alarcon T López-Brea M Nakazawa T Fox JG Correa P Dominguez-Bello MG Perez-Perez GI Blaser MJ Normark S Carlstedt I Oscarson S Teneberg S Berg DE Borén T 《Science (New York, N.Y.)》2004,305(5683):519-522
Adherence by Helicobacter pylori increases the risk of gastric disease. Here, we report that more than 95% of strains that bind fucosylated blood group antigen bind A, B, and O antigens (generalists), whereas 60% of adherent South American Amerindian strains bind blood group O antigens best (specialists). This specialization coincides with the unique predominance of blood group O in these Amerindians. Strains differed about 1500-fold in binding affinities, and diversifying selection was evident in babA sequences. We propose that cycles of selection for increased and decreased bacterial adherence contribute to babA diversity and that these cycles have led to gradual replacement of generalist binding by specialist binding in blood group O-dominant human populations. 相似文献
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Ring species, which consist of two reproductively isolated forms connected by a chain of intergrading populations, have often been described as examples of speciation despite gene flow between populations, but this has never been demonstrated. We used amplified fragment length polymorphism (AFLP) markers to study gene flow in greenish warblers (Phylloscopus trochiloides). These genetic markers show distinct differences between two reproductively isolated forms but gradual change through the ring connecting these forms. These findings provide the strongest evidence yet for "speciation by force of distance" in the face of ongoing gene flow. 相似文献
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Jean-Baptiste Chesneau Elisabeth Le Net Staffan Berg 《European Journal of Forest Research》2012,131(1):73-80
The development of ToSIA (tool for sustainability impact assessment of the Forest Wood Chain) involved to measure economic,
social and environmental indicators of all transformation processes belonging to the Forest Wood Chain (FWC). In this context,
a specific tool has been developed to measure indicators related to almost all transport processes of each European FWC. The
aim of this article is to describe the approach and the method used to set up this tool and also to illustrate some of its
applications through an example. The example shows how the tool can deal with major transport issues by determining, in a
German case, the distances (respectively, 330 and 280 km) setting the economic advantage to use rail and inland waterways
instead of road. Moreover, it evaluates the implications of such changes in term of Green House Gas reduction (respectively,
50 and 56%). 相似文献
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Silvestre García de Jalón Paul J. Burgess Anil Graves Gerardo Moreno Jim McAdam Eric Pottier Sandra Novak Valerio Bondesan Rosa Mosquera-Losada Josep Crous-Durán Joao H. N. Palma Joana A. Paulo Tania S. Oliveira Eric Cirou Yousri Hannachi Anastasia Pantera Régis Wartelle Sonja Kay Nina Malignier Philippe Van Lerberghe Penka Tsonkova Jaconette Mirck Mercedes Rois Anne Grete Kongsted Claudine Thenail Boki Luske Staffan Berg Marie Gosme Andrea Vityi 《Agroforestry Systems》2018,92(4):829-848
Whilst the benefits of agroforestry are widely recognised in tropical latitudes few studies have assessed how agroforestry is perceived in temperate latitudes. This study evaluates how stakeholders and key actors including farmers, landowners, agricultural advisors, researchers and environmentalists perceive the implementation and expansion of agroforestry in Europe. Meetings were held with 30 stakeholder groups covering different agroforestry systems in 2014 in eleven EU countries (Denmark, France, Germany, Greece, Hungary, Italy, Netherlands, Portugal, Spain, Sweden and the United Kingdom). In total 344 valid responses were received to a questionnaire where stakeholders were asked to rank the positive and negative aspects of implementing agroforestry in their region. Improved biodiversity and wildlife habitats, animal health and welfare, and landscape aesthetics were seen as the main positive aspects of agroforestry. By contrast, increased labour, complexity of work, management costs and administrative burden were seen as the most important negative aspects. Overall, improving the environmental value of agriculture was seen as the main benefit of agroforestry, whilst management and socio-economic issues were seen as the greatest barriers. The great variability in the opportunities and barriers of the systems suggests enhanced adoption of agroforestry across Europe will be most likely to occur with specific initiatives for each type of system. 相似文献
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Toward a systems approach to understanding plant cell walls 总被引:2,自引:0,他引:2
Somerville C Bauer S Brininstool G Facette M Hamann T Milne J Osborne E Paredez A Persson S Raab T Vorwerk S Youngs H 《Science (New York, N.Y.)》2004,306(5705):2206-2211
One of the defining features of plants is a body plan based on the physical properties of cell walls. Structural analyses of the polysaccharide components, combined with high-resolution imaging, have provided the basis for much of the current understanding of cell walls. The application of genetic methods has begun to provide new insights into how walls are made, how they are controlled, and how they function. However, progress in integrating biophysical, developmental, and genetic information into a useful model will require a system-based approach. 相似文献
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Mats Hannerz ke Thorsn Staffan Mattsson Jan Weslien 《Forest Ecology and Management》2002,160(1-3):11-17
Damage caused by pine weevil (Hylobius abietus L.) to planted seedlings and cuttings of Norway spruce (Picea abies (L.) Karst.) was studied at five clearcut sites in south-eastern Sweden. The main objective was to compare the two types of stock in terms of attack frequency and mortality due to pine weevil feeding. Cuttings and seedlings with the same initial stem-base diameter (4 mm) were compared. Two sites were harvested and scarified shortly before planting, two were harvested shortly before planting, but were not scarified, and one was harvested 2 years before and scarified the autumn before planting. The total mortality 5 years after planting was highest, greater than 90%, at the new, non-scarified sites, and lowest, 23%, at the old, scarified site. More than 90% of the mortality was caused by pine weevil feeding. Attack frequency and pine weevil induced mortality were significantly higher among seedlings than among cuttings. Mortality due to pine weevil damage was 4–43% higher in seedlings than in cuttings after the fifth year. Of the cuttings and seedlings that were attacked in the first year, a significantly higher frequency of the seedlings were girdled. The higher resistance of cuttings to pine weevil damage may partly explain the more rapid growth of cuttings reported in other studies. However, the causes of their higher resistance need to be further investigated. The thicker bark and needles on the stem base of the cuttings could be important in this respect. 相似文献
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Forestry has an important role to play as a provider of energyfrom renewable biomass and through the sequestration of carbonin biomass and soil. Forests are also habitats for a large numberof species which are important for biodiversity. In some cases,these two roles may conflict. The aim of this study was to modelthe implications of specific environmental quality objectiveson the potential of forestry to reduce net CO2 emissions byaddressing interim targets 1 and 2 in the environmental qualityobjective, sustainable forests for Uppsala County and used thisregion as a case study. The carbon stock in the biomass, thesubstitution effect, and the economic consequences associatedwith six forest management scenarios were considered. The developmentfor the scenarios was simulated at stand level using an empiricalmodel. The results of the study showed that the shortest rotationperiod was preferable to mitigate net CO2 emissions since itresulted in more biomass that could replace fossil fuel. However,such a strategy might affect sustainable policies negatively.Increasing the extent of mixed stands could be a preferablestrategy since it may achieve several objectives. 相似文献