右美托咪定抑制NOX4缓解急性应激致大鼠肾损伤

本研究拟探索右美托咪定（dexmedetomidine,DEX）对大鼠急性应激致肾损伤的保护作用,并从氧化应激的角度探索DEX对大鼠肾的保护通路。本研究使用了急性束缚应激模型,其中,大鼠被迫游泳15 min,并束缚3 h。本试验采用生化检测、组织病理学切片观察以评估肾功能,然后测定了氧化应激以及氧化应激的相关通路蛋白。旷场试验证实成功建立了急性应激模型。急性应激引起的肾损伤增加了NOX4,降低了Nrf2/HO-1/NQO1表达水平。DEX可降低NOX4表达,同时升高Nrf2/HO-1/NQO1的表达水平。DEX治疗组与急性应激组相比的肾生化结果明显恢复正常,病理切片观察损伤显著降低。试验结果表明,DEX治疗急性应激可影响NOX4/Nrf2/HO-1/NQO1信号通路,并抑制氧化应激。因此,DEX对急性应激引起的肾损伤具有保护作用,并在应激综合征中具有潜在的临床应用。     

Regression Applied in Continuous Mathematical Forecast

Data Mining can distill the connotative, unknown and potential value information or pattern from many data. It is a problem that must be settled during the developing of Decision Support System how to discover knowledge from Data Warehouse. In order to realize the continuous mathematical forecast that will be used in the Marketing Decision Support System for Industrial Enterprise, the authors use the method of regression to discuss how to design the algorithm for Data Mining, how to design the model for Data Mining, and so on. When the algorithm applied to the sales forecast, the result processing to simulation data indicates it can realize the expected effect.     

Reference Efficiency of Planetary Gear Train

Reference efficiency of a pair of gear drive without planetary motion is the base to calculate efficiency of the whole planetary gear train. The authors find reference efficiency for speed increase is higher than that of the same drive used for speed reduction. This is different from the earlier viewpoint. New equations are derived for correctly calculating the reference efficiency of spur gear and helical gear with internal conjugate and external conjugate either in the state of speed increase or speed reduction respectively. The equations are also used to calculate efficiency of 2K-H planetary gear train.     

Research on the Realization of Remote Controlling for Multi-output Power Supply of Communication Equipment Based on Ethernet

According to the requirements of communication power supply, such as high reliability, wide application and high availability, the authors raise a new remote control design for a multi-output power supply for communication equipment based on TCPIP protocol and embedded technology. Then the hardware design is given for the system is discussed based on Ethernet professional chip PRTL8019AS and related circuits. The firmware software design for the salve-computer based TCPIP technology, and the soft design of communieation and control for the master-computer are proposed based on Winsoek and MFC technology in detail A test machine is built to do the testing, the test results prove that the test machine works stably and well, satisfies the design rules and also provides a feasible method for the remote supervise in communication power supplier whose requirement includes remote supervise, no-people on duty and so on.     

Vehicle Monitoring Control and Scheduling Management System in a Scenic Area

In order to help tourists choose satisfying scenic spots, content hotels, convenient lines and convenient vehicles, vehicle monitoring control and scheduling management system in a scenic area is presented, which dispatches vehicle by appointments and the statistic of tourists at a sight spot and recommends the tour line by broadcasting in vehicle. Vehicle monitoring control and scheduling management system in a scenic area, a integrative vehicle management system, is an integration of GPS, GIS, trunked radio system, a management system of booking room and a tourist statistic system at a sight spot.     

Expert System for Artificial Intelligence Blast Furnace Smelting Process

In order to upgrade traditional industry and realize the automation of furnace condition judgement and standardization of operation, an expert system for various furnace conditions and breakdown judgement and operation guidance on blast furnace are developed based on the theory of artificial intelligence and knowledge engineering. The system is fulfilled through C++Builder and combined with the actual production picture. The system has efficient and convenient man-machine interface by using menu operation method. The testing and operation of actual production data in simulation system indicate that the system is exact and reliable and can provide both the warning of various furnace breakdown and corresponding operation guidance.     

Modularity Design in Customization Marketing of Third Party Logistics

This paper focuses on the key tactics and technology in customization marketing of Third Party Logistics -design modularity of logistics product, which is be researched deeply. The modularity figure of logistics product, and depth management for modularity are constructed by adopting boston Matrix in order to avoid over-customized. Personality customization is realized through making up module differently for Third Party Logistics corporations, to satisfy the demand for customizing and responding the market fast.     

Controlling Techniques of Channel Sharing in HFC Network

The techniques of sharing a channel in HFC are original with regard to those of Ethernet and Ring. In this paper, the analysis is stressed on the method of the upstream bandwidth allocation, the collision resolving, and the relationship among them, beginning with MAP management message. The MAP is a complex frame, in which the messages of ranging opportunity needed by the CM at the access beginning, bandwidth allocation contention, bandwidth allocation and collision detection are included. The access way for a user is explained after the frame format and functions of a MAP are illustrated. Finally, upstream bandwidth allocation, the cause of collision, algorithm and the process to solve the collision and so on are studied.     

Matter-element Evaluation Model on the Personal Credit of University Students Loan and It''s Application

This paper analyzes the current situation of university students' credit evaluation and set up an evaluation index system of university students' credit to compensate a loan.Based on this index system,this paper sets up a matter-element evaluation model on the individual credit of university students loan by means of extensible engineering method.The grade of individual credit and the index for evaluating the level of individual credit are made as matter-element,meanwhile,the classical field,the segment field,the weight coefficient are obtained.Dependence function is established based on the grade of individual credit and then the grade is judged by calculating the synthetic dependence degree.Finally,this paper presents the evaluation method by giving an example.This method is simple in calculation,reasonable in evaluation with high applicability.