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排序方式: 共有103条查询结果,搜索用时 15 毫秒
101.
Sommers CL Park CS Lee J Feng C Fuller CL Grinberg A Hildebrand JA Lacaná E Menon RK Shores EW Samelson LE Love PE 《Science (New York, N.Y.)》2002,296(5575):2040-2043
Mice homozygous for a single tyrosine mutation in LAT (linker for activation of T cells) exhibited an early block in T cell maturation but later developed a polyclonal lymphoproliferative disorder and signs of autoimmune disease. T cell antigen receptor (TCR)-induced activation of phospholipase C-gamma1 (PLC-gamma1) and of nuclear factor of activated T cells, calcium influx, interleukin-2 production, and cell death were reduced or abrogated in T cells from LAT mutant mice. In contrast, TCR-induced Erk activation was intact. These results identify a critical role for integrated PLC-gamma1 and Ras-Erk signaling through LAT in T cell development and homeostasis. 相似文献
102.
This study was exclusively conducted to evaluate healing of surgically created defects on the radius of adult Black Bengal goat after implantation of porous bioglass blocks and compare the process kinetics with normal healing. Twelve Black Bengal goats were divided randomly into two groups: control and experimental group implanted with bioglass blocks. Unicortical bone defects in radius were generated in all animals under aseptic condition. Local inflammatory reaction and healing of wound, radiological investigations, histological studies, oxytetracycline leveling and angiographic studies were performed up to 90th day post-operatively and compared with normal healing. It has been found that extensive new bone formation originating from host bone towards the implant whereas in control, the process was active from both the ends; the defect site appeared as homogenous nonfluorescent area. Thus, porous bioglass promoted bone formation over the entire extension of the defect independent of size of block in comparison to control group. 相似文献
103.
Purohit Sumit Jugran Arun K. Bhatt Indra D. Nandi Shyamal K. 《Genetic Resources and Crop Evolution》2022,69(5):1737-1752
Genetic Resources and Crop Evolution - Zanthoxylum armatum DC. (Family Rutaceae) is an important species gaining tremendous popularity owing to its multiple uses in diverse medicine systems. The... 相似文献