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排序方式: 共有206条查询结果,搜索用时 15 毫秒
31.
Laura Marconato Carmit Chalfon Riccardo Finotello Gerry Polton Maria E. Vasconi Maurizio Annoni Damiano Stefanello Paola Mesto Ombretta Capitani Chiara Agnoli Maria Amati Silvia Sabattini 《Veterinary and comparative oncology》2019,17(4):537-544
Treatment options for dogs with metastatic (stage III) splenic hemangiosarcoma are limited. A doxorubicin‐based chemotherapy regimen is commonly administered; however, there are no published data to support this practice. The aim of this study was to investigate the impact of maximum‐tolerated‐dose chemotherapy (MTD), metronomic chemotherapy (MC) and no adjuvant treatment on outcome in dogs with stage III splenic hemangiosarcoma undergoing splenectomy. Medical records of dogs with stage III splenic hemangiosarcoma that underwent splenectomy followed by MTD chemotherapy, MC or no adjuvant treatment were retrieved. Time to progression (TTP), survival time (ST) and toxicity were evaluated. One hundred three dogs were identified: 23 received adjuvant MTD, 38 MC and 42 were not medically treated. Overall median TTP and ST were 50 (95% confidence interval [CI], 39‐61) and 55 days (95% CI, 43‐66), respectively. Dogs treated with adjuvant MTD had a significantly longer TTP and ST compared with dogs receiving MC (median TTP, 134 vs 52 days, P = .025; median ST, 140 vs 58 days, P = .023, respectively). Dogs treated by splenectomy only had the shortest median TTP (28 days) and ST (40 days). However, treatment‐related adverse events (AEs) were significantly more frequent in the MTD group (P = .017). The outcome for dogs with metastatic splenic hemangiosarcoma is poor. While MTD showed greater efficacy compared to MC, toxicity was higher in this group. Treatment‐related AEs need to be carefully balanced against this modest survival prolongation when offering adjuvant MTD to dogs with advanced stage hemangiosarcoma. 相似文献
32.
Schirawski J Mannhaupt G Münch K Brefort T Schipper K Doehlemann G Di Stasio M Rössel N Mendoza-Mendoza A Pester D Müller O Winterberg B Meyer E Ghareeb H Wollenberg T Münsterkötter M Wong P Walter M Stukenbrock E Güldener U Kahmann R 《Science (New York, N.Y.)》2010,330(6010):1546-1548
Biotrophic pathogens, such as the related maize pathogenic fungi Ustilago maydis and Sporisorium reilianum, establish an intimate relationship with their hosts by secreting protein effectors. Because secreted effectors interacting with plant proteins should rapidly evolve, we identified variable genomic regions by sequencing the genome of S. reilianum and comparing it with the U. maydis genome. We detected 43 regions of low sequence conservation in otherwise well-conserved syntenic genomes. These regions primarily encode secreted effectors and include previously identified virulence clusters. By deletion analysis in U. maydis, we demonstrate a role in virulence for four previously unknown diversity regions. This highlights the power of comparative genomics of closely related species for identification of virulence determinants. 相似文献
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Rocco Latorre Maurizio Mazzoni Roberto De Giorgio Claudia Vallorani Alessio Bonaldo Pier Paolo Gatta Roberto Corinaldesi Eugenio Ruggeri Chiara Bernardini Roberto Chiocchetti Catia Sternini Paolo Clavenzani 《Fish physiology and biochemistry》2013,39(6):1555-1565
In vertebrates, chemosensitivity of nutrients occurs through the activation of taste receptors coupled with G-protein subunits, including α-transducin (Gαtran) and α-gustducin (Gαgust). This study was aimed at characterising the cells expressing Gαtran immunoreactivity throughout the mucosa of the sea bass gastrointestinal tract. Gαtran immunoreactive cells were mainly found in the stomach, and a lower number of immunopositive cells were detected in the intestine. Some Gαtran immunoreactive cells in the stomach contained Gαgust immunoreactivity. Gastric Gαtran immunoreactive cells co-expressed ghrelin, obestatin and 5-hydroxytryptamine immunoreactivity. In contrast, Gαtran immunopositive cells did not contain somatostatin, gastrin/cholecystokinin, glucagon-like peptide-1, substance P or calcitonin gene-related peptide immunoreactivity in any investigated segments of the sea bass gastrointestinal tract. Specificity of Gαtran and Gαgust antisera was determined by Western blot analysis, which identified two bands at the theoretical molecular weight of ~45 and ~40 kDa, respectively, in sea bass gut tissue as well as in positive tissue, and by immunoblocking with the respective peptide, which prevented immunostaining. The results of the present study provide a molecular and morphological basis for a role of taste-related molecules in chemosensing in the sea bass gastrointestinal tract. 相似文献
36.
分别利用1995—2000年的ERS-1/2串行数据和2005年的Envisat ASAR数据对我国东北林区进行森林制图研究。针对ERS-1/2数据相干模型,采用一种不依靠地面实况数据而是基于MODIS植被连续覆盖产品进行训练的方法,从而实现进行大区域森林蓄积量分级制图的目的。分级制图包括0~20、20~50、50~80和80 m3/hm2 4个蓄积量等级。基于Envisat ASAR数据,采用面向对象的分类方法,进行自动化森林和非森林分类处理。基于2005年Landsat TM-5分类结果的交叉验证表明:这2种传感器SAR数据均可用于大区域森林制图。2期森林制图结果为进一步的森林变化分析以及制图更新研究提供支持。 相似文献
37.
Vicentini CB Forlani G Manfrini M Romagnoli C Mares D 《Journal of agricultural and food chemistry》2002,50(17):4839-4845
Some pyrazolo[3,4-d]pyrimidin-4(5H)-thione, pyrazolo[3,4-d][1,3]thiazin-4-one/thione, and pyrazolo[1,5-c][1,3,5]thiadiazine-4-one/thione derivatives were synthesized and screened for antifungal activity against the causal agent of rice blast disease, Magnaporthe grisea. In all cases a remarkable inhibition of fungal growth was found in the range from 10 to 200 microg x mL(-1). Several compounds were able to control mycelium growth at a rate of 10 microg x mL(-1), a concentration at which the reference compound tricyclazole was completely ineffective. At least in the case of the most active substance, at the same dose the growth of seedlings or cultured cells of rice was substantially unaffected. Results allowed definition of structural requirements either to maintain or to enhance mycotoxic activity. 相似文献
38.
José M. Alvarez-Suarez Francesca Giampieri Massimiliano Gasparrini Luca Mazzoni Tamara Y. Forbes-Hernández Sadia Afrin Maurizio Battino 《Plant foods for human nutrition (Dordrecht, Netherlands)》2018,73(1):18-24
We analyzed guava fruits (Psidium guajava L. cv. Red Suprema) from Cuba to determine their chemical composition, total antioxidant capacity, as well as their protective effect against oxidative damage using an in vitro model of human dermal fibroblasts. The guava fruit is a natural source of bioactive compounds, such as polyphenols, vitamin C, folates and beta carotenes with proven health benefits. Human dermal fibroblasts were pre-incubated with different concentrations of guava crude extract and then subjected to oxidative stress using the AAPH stressor. The number of apoptotic and dead cells, as well as the markers of oxidative damage such as lipid and protein oxidation significantly decreased when cells were pre-incubated with guava crude extract and then exposed to the stressor. The activity of antioxidant enzymes also improved when cells were pre-incubated with guava crude extract in comparison to cells subjected to stress without prior pre-incubation with the guava extract. The results obtained in this study highlight the health benefits of guava regarding oxidative stress, proving it to be an important source of bioactive compounds associated with important biological properties. 相似文献
39.
Albania is facing serious problems with the national food safety control system in terms of legislation, control and enforcement. The objective of this paper is to analyse consumer perceptions about safety of small ruminant meat in Tirana, in a context of weak enforcement of the food safety system. Applying two-step clustering analyses, consumers were classified in four socio-demographic clusters, and it was found that the cluster composed of female consumers with lower education and income levels, and the two clusters composed of male consumers perceive consumed meat as safe. Consumers in the cluster composed of females with university education and higher income are, on average, more concerned with current meat safety measures and tend to place more trust in the veterinarian stamp on meat carcasses rather than in local butchers. 相似文献
40.
Generalized functions of biomass expansion factors for conifers and broadleaved by stand age,growing stock and site index 总被引:1,自引:0,他引:1
Maurizio Teobaldelli Zoltan Somogyi Mirco Migliavacca Vladimir A. Usoltsev 《Forest Ecology and Management》2009
Parties to the Kyoto Protocol and/or the United Nations Framework Convention on Climate Change (UNFCCC) are required to account for their direct human-induced carbon emissions and removals including those from forestry and other land use related activities. In most European countries, the forestry related greenhouse gas inventories are largely or exclusively based on converting tree volume data from national forest inventories to biomass using biomass conversion and expansion factors (BCEFs). However, country specific data for many species are often lacking, which considerably increases the uncertainties of the greenhouse gas inventories. The focus of this research was to develop, using internationally published datasets that cover a large geographical area, an extended set of generalized curves of such biomass expansion factors for several species or species groups by age, growing stock and site index. 相似文献