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891.
Igakura T Stinchcombe JC Goon PK Taylor GP Weber JN Griffiths GM Tanaka Y Osame M Bangham CR 《Science (New York, N.Y.)》2003,299(5613):1713-1716
Cell contact is required for efficient transmission of human T cell leukemia virus- type 1 (HTLV-I) between cells and between individuals, because naturally infected lymphocytes produce virtually no cell-free infectious HTLV-I particles. However, the mechanism of cell-to-cell spread of HTLV-I is not understood. We show here that cell contact rapidly induces polarization of the cytoskeleton of the infected cell to the cell-cell junction. HTLV-I core (Gag protein) complexes and the HTLV-I genome accumulate at the cell-cell junction and are then transferred to the uninfected cell. Other lymphotropic viruses, such as HIV-1, may similarly subvert normal T cell physiology to allow efficient propagation between cells. 相似文献
892.
Daniel C Full J González L Lupulescu C Manz J Merli A Vajda S Wöste L 《Science (New York, N.Y.)》2003,299(5606):536-539
Femtosecond high-resolution pump-probe experiments have been used together with theoretical ab initio quantum calculations and wave packet dynamics simulations to decode an optimal femtosecond pulse that is generated from adaptive learning algorithms. This pulse is designed to maximize the yield of the organometallic ion CpMn(CO)3 while hindering the competing fragmentation. The sequential excitation and ionization of the target ion are accomplished by an optimized field consisting of two dominant subpulses with optimal frequencies and time delays. 相似文献
893.
The bacterium Proteus mirabilis is capable of movement on solid surfaces by a type of motility called swarming. Boundaries form between swarming colonies of different P. mirabilis strains but not between colonies of a single strain. A fundamental requirement for boundary formation is the ability to discriminate between self and nonself. We have isolated mutants that form boundaries with their parent. The mutations map within a six-gene locus that we term ids for identification of self. Five of the genes in the ids locus are required for recognition of the parent strain as self. Three of the ids genes are interchangeable between strains, and two encode specific molecular identifiers. 相似文献
894.
The structure of ferrihydrite, a nanocrystalline material 总被引:2,自引:0,他引:2
Michel FM Ehm L Antao SM Lee PL Chupas PJ Liu G Strongin DR Schoonen MA Phillips BL Parise JB 《Science (New York, N.Y.)》2007,316(5832):1726-1729
Despite the ubiquity of ferrihydrite in natural sediments and its importance as an industrial sorbent, the nanocrystallinity of this iron oxyhydroxide has hampered accurate structure determination by traditional methods that rely on long-range order. We uncovered the atomic arrangement by real-space modeling of the pair distribution function (PDF) derived from direct Fourier transformation of the total x-ray scattering. The PDF for ferrihydrite synthesized with the use of different routes is consistent with a single phase (hexagonal space group P6(3)mc; a = approximately 5.95 angstroms, c = approximately 9.06 angstroms). In its ideal form, this structure contains 20% tetrahedrally and 80% octahedrally coordinated iron and has a basic structural motif closely related to the Baker-Figgis delta-Keggin cluster. Real-space fitting indicates structural relaxation with decreasing particle size and also suggests that second-order effects such as internal strain, stacking faults, and particle shape contribute to the PDFs. 相似文献
895.
Drissner D Kunze G Callewaert N Gehrig P Tamasloukht M Boller T Felix G Amrhein N Bucher M 《Science (New York, N.Y.)》2007,318(5848):265-268
The arbuscular mycorrhizal (AM) symbiosis represents the most widely distributed mutualistic root symbiosis. We report that root extracts of mycorrhizal plants contain a lipophilic signal capable of inducing the phosphate transporter genes StPT3 and StPT4 of potato (Solanum tuberosum L.), genes that are specifically induced in roots colonized by AM fungi. The same signal caused rapid extracellular alkalinization in suspension-cultured tomato (Solanum lycopersicum L.) cells and induction of the mycorrhiza-specific phosphate transporter gene LePT4 in these cells. The active principle was characterized as the lysolipid lyso-phosphatidylcholine (LPC) via a combination of gene expression studies, alkalinization assays in cell cultures, and chromatographic and mass spectrometric analyses. Our results highlight the importance of lysophospholipids as signals in plants and in particular in the AM symbiosis. 相似文献
896.
Coleman JN Lotya M O'Neill A Bergin SD King PJ Khan U Young K Gaucher A De S Smith RJ Shvets IV Arora SK Stanton G Kim HY Lee K Kim GT Duesberg GS Hallam T Boland JJ Wang JJ Donegan JF Grunlan JC Moriarty G Shmeliov A Nicholls RJ Perkins JM Grieveson EM Theuwissen K McComb DW Nellist PD Nicolosi V 《Science (New York, N.Y.)》2011,331(6017):568-571
If they could be easily exfoliated, layered materials would become a diverse source of two-dimensional crystals whose properties would be useful in applications ranging from electronics to energy storage. We show that layered compounds such as MoS(2), WS(2), MoSe(2), MoTe(2), TaSe(2), NbSe(2), NiTe(2), BN, and Bi(2)Te(3) can be efficiently dispersed in common solvents and can be deposited as individual flakes or formed into films. Electron microscopy strongly suggests that the material is exfoliated into individual layers. By blending this material with suspensions of other nanomaterials or polymer solutions, we can prepare hybrid dispersions or composites, which can be cast into films. We show that WS(2) and MoS(2) effectively reinforce polymers, whereas WS(2)/carbon nanotube hybrid films have high conductivity, leading to promising thermoelectric properties. 相似文献
897.
Average crustal models for the northeastern United States are computed on the basis of the travel times of P and S waves from regional earthquakes. The Precambrian Grenville Province in New York State has a relatively homogeneous crust. The Paleozoic New England Appalachians have a well-defined, two-layer crust that is slightly thicker and shows a high-velocity lower layer relative to the Grenville. A time-term analysis based on P(n) data (waves refracted from the Moho) shows that a relatively thick or low-velocity crust parallels northeast-trending geologic structures in central New England. The observed differences between the two orogenic belts may reflect contrasts in their tectonic evolution. 相似文献
898.
Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations 总被引:1,自引:0,他引:1
In the cerebral cortex, diverse types of neurons form intricate circuits and cooperate in time for the processing and storage of information. Recent advances reveal a spatiotemporal division of labor in cortical circuits, as exemplified in the CA1 hippocampal area. In particular, distinct GABAergic (gamma-aminobutyric acid-releasing) cell types subdivide the surface of pyramidal cells and act in discrete time windows, either on the same or on different subcellular compartments. They also interact with glutamatergic pyramidal cell inputs in a domain-specific manner and support synaptic temporal dynamics, network oscillations, selection of cell assemblies, and the implementation of brain states. The spatiotemporal specializations in cortical circuits reveal that cellular diversity and temporal dynamics coemerged during evolution, providing a basis for cognitive behavior. 相似文献
899.
Li W Pohl T Rost JM Rittenhouse ST Sadeghpour HR Nipper J Butscher B Balewski JB Bendkowsky V Löw R Pfau T 《Science (New York, N.Y.)》2011,334(6059):1110-1114
Permanent electric dipole moments in molecules require a breaking of parity symmetry. Conventionally, this symmetry breaking relies on the presence of heteronuclear constituents. We report the observation of a permanent electric dipole moment in a homonuclear molecule in which the binding is based on asymmetric electronic excitation between the atoms. These exotic molecules consist of a ground-state rubidium (Rb) atom bound inside a second Rb atom electronically excited to a high-lying Rydberg state. Detailed calculations predict appreciable dipole moments on the order of 1 Debye, in excellent agreement with the observations. 相似文献
900.
We examine changing production relations in the Mexican tequila industry to explore the ways in which large industrial firms
are using “reverse leasing arrangements,” a form of contract farming, to extend their control over small agave farmers. Under
these arrangements, smallholders rent their parcels to contracting companies who bring in capital, machinery, labor, and other
agricultural inputs. Smallholders do not have access to their land, nor do they make any of the management decisions. We analyze
the factors that have led some producers to participate in reverse leasing arrangements, while allowing other producers to
continue farming independently. In addition, we look at the ways in which farmers are responding to these new production relations
and constraints and the strategies that they are using to regain control over the production process.
相似文献
Sarah BowenEmail: |