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991.
Hazuda DJ Felock P Witmer M Wolfe A Stillmock K Grobler JA Espeseth A Gabryelski L Schleif W Blau C Miller MD 《Science (New York, N.Y.)》2000,287(5453):646-650
Integrase is essential for human immunodeficiency virus-type 1 (HIV-1) replication; however, potent inhibition of the isolated enzyme in biochemical assays has not readily translated into antiviral activity in a manner consistent with inhibition of integration. In this report, we describe diketo acid inhibitors of HIV-1 integrase that manifest antiviral activity as a consequence of their effect on integration. The antiviral activity of these compounds is due exclusively to inhibition of one of the two catalytic functions of integrase, strand transfer. 相似文献
992.
Electron microscopic autoradiography indicates that only a fraction of ribosome-containing reticulocytes (from phenylhydrazine-treated rabbits) is capable of active protein synthesis in vitro. Ribosomes, and, indeed, polyribosomes, do not appear to limit the rate of protein synthesis. 相似文献
993.
994.
Rhesus Macaque Genome Sequencing Analysis Consortium Gibbs RA Rogers J Katze MG Bumgarner R Weinstock GM Mardis ER Remington KA Strausberg RL Venter JC Wilson RK Batzer MA Bustamante CD Eichler EE Hahn MW Hardison RC Makova KD Miller W Milosavljevic A Palermo RE Siepel A Sikela JM Attaway T Bell S Bernard KE Buhay CJ Chandrabose MN Dao M Davis C Delehaunty KD Ding Y Dinh HH Dugan-Rocha S Fulton LA Gabisi RA Garner TT Godfrey J Hawes AC Hernandez J Hines S Holder M Hume J Jhangiani SN 《Science (New York, N.Y.)》2007,316(5822):222-234
995.
996.
In a ferromagnet, an applied electric field E invariably produces an anomalous Hall current JH that flows perpendicular to the plane defined by E and M (the magnetization). For decades, the question of whether JH is dissipationless (independent of the scattering rate) has been debated without experimental resolution. In the ferromagnetic spinel CuCr2Se4-xBrx, the resistivity rho (at low temperature) may be increased by several decades by varying x (Br) without degrading M. We show that JH/E (normalized per carrier, at 5 kelvin) remains unchanged throughout. In addition to confirming the dissipationless nature of JH, our finding has implications for the generation and study of spin-Hall currents in bulk samples. 相似文献
997.
McKeever J Boca A Boozer AD Miller R Buck JR Kuzmich A Kimble HJ 《Science (New York, N.Y.)》2004,303(5666):1992-1994
A single cesium atom trapped within the mode of an optical cavity is used to generate single photons on demand. The photon wave packets are emitted as a Gaussian beam with temporal profile and repetition rate controlled by external driving fields. Each generation attempt is inferred to succeed with a probability near unity, whereas the efficiency for creating an unpolarized photon in the total cavity output is 0.69 +/- 0.10, as limited by passive cavity losses. An average of 1.4 x 10(4) photons are produced by each trapped atom. These results constitute an important step in quantum information science, for example, toward the realization of distributed quantum networking. 相似文献
998.
Human immunodeficiency virus may encode a novel protein on the genomic DNA plus strand 总被引:5,自引:0,他引:5
R H Miller 《Science (New York, N.Y.)》1988,239(4846):1420-1422
The genome of the human immunodeficiency virus (HIV) is known to contain eight open reading frames (ORFs) on the minus strand of the double-stranded DNA replicative intermediate. Data presented here indicate that the DNA plus strand of HIV contains a previously unidentified ORF in a region complementary to the envelope gene sequence. This ORF could encode a protein of approximately 190 amino acid residues with a relative molecular mass of 20 kilodaltons if translation began from the first initiation codon. The predicted protein is highly hydrophobic and thus could be membrane associated. It is possible, therefore, that the HIV genome encodes a protein on antisense messenger RNA. 相似文献
999.
Cyclic adenosine monophosphate: function in photoreceptors 总被引:2,自引:0,他引:2
Inactivation of adenylate cyclase in outer segments of retinal photoreceptor cells is proportional to the bleaching of rhodopsin. Membranes of the outer segments also contain a particulate, light-insensitive phosphodiesterase of high specific activity. In electrophysiological experiments, application of cyclic adenosine monophosphate along with a methylxanthine mimics the effects of illumination on the photoreceptor cell of the compound eye of Limulus. 相似文献
1000.
Miller SL 《Science (New York, N.Y.)》1969,165(3892):489-490
Measurements of the dissociation pressure of nitrogen hydrate and oxygen hydrate show that the clathrate hydrate of air with the formula (N(2), O(2)) 6H(2)O should exist below about 800 meters in the Antarctic ice sheet. This accounts for the disappearance of gas bubbles at depths greater than 1200 meters. The hydrate should exist from this depth to prise 0.06 percent of the ice. 相似文献